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amakuru

HPMC ni iki?

HPMC Hydroxypropyl methylcellulose, izwi kandi nka hypromellose, ni imwe muri ether ya selile idafite ionic ivanze.Nibice bya sintetike, idakora, viscoelastic polymer ikunze gukoreshwa nkamavuta yo kuvura amaso, cyangwa nkibintu byoroshye cyangwa byoroshye mumiti yo munwa.

Izina ryibicuruzwa Hydroxypropyl methyl selulose (HPMC)
Irindi zina Hydroxypropyl methylcellulose, MHPC, methyl Hydroxypropyl selulose
CAS Kwiyandikisha Numero 9004-65-3
Kugaragara fibrous yera cyangwa ifu ya granular
ibisobanuro byumutekano S24 / 25

Imiterere yumubiri nubumara
Kugaragara: fibrous yera cyangwa hafi yera cyangwa ifu ya granular
Igihagararo: Ibikomeye birashya kandi ntibishobora kubangikanya na okiside ikomeye.
Ubunini;Intsinzi ya mesh 100 yari hejuru ya 98.5%.Igipimo cyo gutsinda amaso 80 ni 100%.Ingano idasanzwe yubunini bwa 40 ~ 60 mesh.
Ubushyuhe bwa Carbone: 280-300 ℃
Ubucucike bugaragara: 0.25-0.70g / cm3 (mubisanzwe hafi 0.5g / cm3), uburemere bwihariye 1.26-1.31.
Guhindura amabara ubushyuhe: 190-200 ℃
Ubushyuhe bwo hejuru: 42-56dyne / cm mumuti wa 2%
Gukemura: gushonga mumazi hamwe na solve zimwe, nkigipimo gikwiye cya Ethanol / amazi, propanol / amazi, nibindi. Igisubizo cyamazi gifite ibikorwa byubutaka.Gukorera mu mucyo mwinshi, imikorere ihamye, ibisobanuro bitandukanye byubushyuhe bwa geli buratandukanye, guhinduka gukemuka hamwe nubukonje, uko ubukonje bugenda bugabanuka, niko bigenda byoroha cyane, ibisobanuro bitandukanye byimikorere ya HPMC bifite itandukaniro runaka, igisubizo cya HPMC mumazi ntabwo cyatewe na pH agaciro.
Igikorwa cyo hejuru cya HPMC cyaragabanutse hamwe no kugabanuka kwa vitamine, kwiyongera kwa gel point no kugabanuka kwamazi.
HPMC ifite kandi ubushobozi bwo kubyimba, kurwanya umunyu ifu yivu, pH ihagaze neza, kugumana amazi, guhagarara neza, gukora firime nziza, ndetse no kurwanya inzitizi nyinshi, gutandukana no kuranga.

Uburyo bwo gukora
Cellulose itunganijwe neza ivurwa na lye kuri 35-40 ℃ mugihe cyigice cyisaha, ikanda, selile irajanjagurwa kandi igasaza kuri 35 ℃, kuburyo impuzandengo ya polymerisiyumu ya fibre ya alkali yabonetse iri murwego rusabwa.Shira fibre ya alkali mumasafuriya ya etherification, ongeramo okiside ya propylene na metani chloride ikurikiranye, etherize kuri 50-80 ℃ kuri 5h, umuvuduko mwinshi ni 1.8mpa.Noneho shyiramo urugero rwa acide hydrochloric hamwe nibikoresho byo koza aside aside muri 90 water amazi ashyushye kugirango wongere amajwi.Iyo amazi arimo mubikoresho ari munsi ya 60%, yumishwa kugeza munsi ya 5% numuyaga ushushe kuri 130 ℃.Kurangiza, ibicuruzwa byarangiye birajanjagurwa kandi byerekanwe muri mesh 20.

Uburyo bwo gusesa
1, moderi zose zirashobora kongerwaho ibikoresho muburyo bwo kuvanga byumye.

2, ukeneye kongerwaho muburyo budasanzwe bwamazi yubushyuhe, nibyiza gukoresha ikwirakwizwa ryamazi akonje, nyuma yo kongeramo muri rusange muminota 10-90 kugirango ubyimbye.
3. Moderi isanzwe irashobora gushonga nyuma yo kuvanga no gutatanya namazi ashyushye no kongeramo amazi akonje nyuma yo gukurura no gukonja.
4. Iyo gushonga, niba phenomenon ya agglomerating ibaye, ni ukubera kuvanga bidahagije cyangwa moderi zisanzwe zongerwaho mumazi akonje.Muri iki gihe, bigomba gukangurwa vuba.
5. Niba ibibyimba bibaye mugihe cyo guseswa, birashobora gukurwaho uhagaze kumasaha 2-12 (igihe cyihariye giterwa no guhuza igisubizo) cyangwa mukuvunika no gukanda, cyangwa mukongeramo umubare ukwiye wibintu bisebanya.

HPMC ikoresha
Ikoreshwa nkibyimbye, ikwirakwiza, binder, exiphant, amavuta yihanganira amavuta, yuzuza, emulifier na stabilisateur mu nganda z’imyenda.Ikoreshwa cyane muri resinike yubukorikori, peteroli-chimique, ceramic, impapuro, uruhu, ubuvuzi, ibiryo na cosmetike nizindi nganda.

Intego nyamukuru
1, inganda zubaka: nkumukozi wo kubika amazi ya sima, sima ya retarder hamwe na pompe.Mu guhomesha, gypsumu, ifu ya putty cyangwa ibindi bikoresho byubaka nkibifata neza, kunoza daub no kongera igihe cyo gukora.Ikoreshwa mukwomekaho ceramic tile, marble, imitako ya plastike, paste ikomeza agent, irashobora kugabanya dosiye ya sima.Imikorere yo gufata amazi ya HPMC ituma ubunebwe nyuma yo kubisabwa bitazaterwa no gukama vuba kandi bikavunika, byongera imbaraga nyuma yo gukomera.
2, gukora ceramic: ikoreshwa cyane nkibifatika mugukora ibicuruzwa.
3, inganda zitwikiriye: mu nganda zitwikiriye nkibyimbye, bitatanya kandi bigahindura, mumazi cyangwa ibishishwa kama bifite solubile nziza.Nkukuraho irangi.
4, icapiro rya wino: muruganda rwa wino nkibyimbye, bitatanye na stabilisateur, mumazi cyangwa ibishishwa kama bifite solubile nziza.
5, plastike: yo gukora agent irekura, yoroshye, amavuta, nibindi.
6, PVC: Umusaruro wa PVC nkuwatatanye, guhagarika polymerisation yo gutegura abafasha nyamukuru ba PVC.
7, uruganda rukora imiti: ibikoresho byo gutwikira;Ibikoresho bya Membrane;Igipimo kigenzurwa na polymer ibikoresho byo gukomeza-kurekura;Umukozi uhamye;Imfashanyo yahagaritswe;Ibikoresho bifata ibinini;Yongera goo
8, Abandi: nayo ikoreshwa cyane mubikorwa byuruhu, ibicuruzwa byimpapuro, kubungabunga imbuto nimboga ninganda.

Porogaramu yihariye yinganda

Inganda zubaka
1, isima ya sima: kunoza ikwirakwizwa rya sima - umucanga, kunoza cyane plastike no kugumana amazi ya minisiteri, kugirango wirinde kumeneka bigira ingaruka, bishobora kongera imbaraga za sima.

2, ceramic tile cima ciment: kunoza plastike ya ceramic tile mortar, kubika amazi, kunoza kashe ya tile ceramic, kwirinda ifu.
3, asibesitosi hamwe nandi mashanyarazi yangiritse: nkumukozi uhagarika, umukozi wo kunoza ibintu, ariko kandi anonosora umusingi wibikoresho bya kole.
4, gypsum slurry: kunoza gufata neza no gutunganya, kunoza ifatizo ryibanze.
5, sima ihuriweho: ongeramo ikibaho cya gypsumu hamwe na sima ihuriweho, kunoza amazi no kubika amazi.
6, latex putty: kunoza amazi no kugumana amazi ya resin latex ishingiye kuri putty.
7, minisiteri: nk'igisimbuza paste karemano, irashobora kunoza gufata neza amazi, kunoza ingirakamaro hamwe na base.
8, gutwikira: nka plasitike ya latx yatwikiriye, ifite uruhare mukuzamura imikorere yimikorere nubworoherane bwamavuta hamwe nifu ya putty.
9, gutera ibiti: kurinda sima cyangwa latex gutera gusa ibintu byuzuza ibintu kurohama no kunoza imigendekere no gushushanya ibishushanyo mbonera bifite ingaruka nziza.
10, sima, gypsumu yibicuruzwa bya kabiri: nka sima - asibesitosi nibindi bikoresho bya hydraulic bikanda kubumba, kunoza amazi, birashobora kubona ibicuruzwa bimwe.
11, urukuta rwa fibre: kubera anti-enzyme anti-bagiteri, kuko guhuza urukuta rwumucanga bifite akamaro.
12, ibindi: birashobora gukoreshwa nka minisiteri yoroheje ya minisiteri na minisiteri ikora ya bubble ifata agent.

Inganda zikora imiti
1, vinyl chloride, vinyl polymerisation: nka polymerisation ihagarika stabilisateur, ikwirakwiza, hamwe na vinyl alcool (PVA) hydroxypropyl selulose (HPC) kandi irashobora kugenzura ikwirakwizwa ryimiterere yibice.
2.
3. Imiti yica udukoko: yongewe kumiti yica udukoko nudukoko, irashobora kunoza ingaruka zifatika mugihe utera.
4, latex: kunoza asifalt emulion stabilisateur, styrene butadiene rubber (SBR) latex.
5, binder: nk'ikaramu, crayon ikora ifata.

Inganda zo kwisiga
1. Shampoo: kunoza ubwiza no gutuza kwinshi kwa shampoo, detergent na detergent.
2. Umuti wamenyo: Kunoza amazi yinyo yinyo.

Inganda zikora ibiribwa
1, citrus yamashanyarazi: irinde mukubungabunga bitewe no kubora kwa glycoside ya orange no kwera metamorphism kugirango ugere gushya.
2, ibicuruzwa byimbuto bikonje: ongeramo ikime cyimbuto, urubura rwa ice, kora uburyohe.
3, isosi: nk'isosi, isosi y'inyanya emulizing stabilisateur cyangwa umubyimba.
4, amazi akonje atwikiriye: akoreshwa mububiko bwamafi yakonje, arashobora kwirinda ibara, kugabanuka kwiza, hamwe na methyl selulose cyangwa hydroxypropyl methyl selulose yumuti wasize glazing, hanyuma igakonjeshwa kurubura.
5, gufatira ibinini: nkibintu bifata ibinini n'ibinini, guhuza no gusenyuka (guhita bishonga kandi bigatatana iyo ufashe) nibyiza.

Inganda zimiti
1. Igipfundikizo: igikoresho cyo gutwikamo gikozwe mubisubizo kama cyangwa igisubizo cyamazi kubinini, cyane cyane kubice bikozwe mumiti ya spray.
2, gahoro gahoro: garama 2-3 kumunsi, burigihe buri gihe 1-2G, muminsi 4-5 kugirango yerekane ingaruka.
3, ubuvuzi bwamaso: kubera ko umuvuduko wa osmotic wa hydroxypropyl methyl selulose yumuti wamazi ameze nkamarira, nuko rero ari mato mumaso, ongeramo imiti yijisho, nkamavuta yo guhuza amaso yijisho.
4, gelatinous agent: nkibikoresho fatizo byubuvuzi bwa gelatine cyangwa amavuta.
5, gutera inda: nkumubyimba, umukozi wo gufata amazi.

Inganda
1, ibikoresho bya elegitoronike: nka ceramic yamashanyarazi, bauxite ferrite magnetiki yumuvuduko ukabije, irashobora gukoreshwa hamwe na 1.2-propylene glycol.
2, glaze: ikoreshwa nka ceramic glaze na farashi hamwe na enamel, irashobora kunoza guhuza no gutunganya.
3, minisiteri yangiritse: ongeramo minisiteri yangiritse cyangwa ibikoresho byo mu itanura, birashobora kunoza plastike no kubika amazi.

Izindi nganda
1, fibre: nko gucapa irangi ryirangi ryibara ryibara, irangi ryamashyamba ya boron, irangi ryumunyu, irangi ryimyenda, wongeyeho, mugutunganya ibicuruzwa bya kapok, birashobora gukoreshwa hamwe nubushyuhe bukomeye.
2, impapuro: zikoreshwa mu mpapuro za karubone zifata uruhu no gutunganya amavuta nibindi bintu.
3, uruhu: nk'amavuta ya nyuma cyangwa gukoresha imiti ikoreshwa.
4, wino ishingiye kumazi: yongewe kumazi ashingiye kumazi, wino, nkumubyimba, umukozi ukora firime.
5, itabi: nk'ifata ry'itabi ryongeye gukoreshwa.

Ibipimo bya Pharmacopoeia

Inkomoko n'ibirimo
Ibicuruzwa ni 2- hydroxypropyl ether methyl selulose.Hydroxypropyl methylcellulose irashobora kugabanywamo amoko ane ukurikije ibikubiye muri mikorobe na hydroxypropyl, aribyo 1828, 2208, 2906, 2910. Ibiri muri buri kintu cyasimbuwe (-OCH3) na hydroxypropoxy (-OCH2ChohCH3) bigomba kubahiriza ibiteganijwe kumugereka. ameza.

imiterere
Ibicuruzwa byera cyangwa quasi-yera fibrous cyangwa ifu ya granular;Impumuro nziza.
Ibicuruzwa hafi ya byose bidashonga muri Ethanol ya anhydrous, ether na acetone;Kubyimba mumazi akonje kugirango bibe igisubizo gisobanutse cyangwa gike cyane.

Kumenya
.Shira 2mL yumuti mumiyoboro yipimisha, shyiramo buhoro buhoro 1mL ya 0,035% ya anthracene sulfurike acide acide kurukuta rwigituba, uyishyire muminota 5, kandi impeta yubururu-icyatsi kibisi igaragara hagati yimbere yamazi yombi.
(2) Ingano ikwiye y'amazi ya viscous yamenyekanye (1) asukwa ku isahani.Nyuma yo guhumeka amazi, hashyizweho urwego rwa firime ikomeye.

kugenzura
1, ph

Nyuma yo gukonjesha, hindura igisubizo kuri 100g ukoresheje amazi hanyuma ubireke kugeza bishonge burundu.Menya ukurikije amategeko (Umugereka ⅵ H, Igice cya II cya Pharmacopoeia, integuro ya 2010).Agaciro PH igomba kuba 5.0-8.0.
2, ubwiza
2.0% (g / g) guhagarikwa byateguwe mu gufata 10.0g yibicuruzwa no kongeramo 90 ℃ amazi kugirango uburemere bwikitegererezo hamwe namazi 500.0g nkibicuruzwa byumye.Ihagarikwa ryashutswe rwose muminota 10 kugeza ibice bitatanye rwose kandi bitose.Ihagarikwa ryakonje mu bwogero bwa barafu kandi rikomeza kubyutsa iminota 40 mugihe cyo gukonja.Icyuma kimwe cya silindari kizunguruka (ndJ-1 gishobora gukoreshwa kuburugero rufite ubukonje buri munsi ya 100Pa · s, na NDJ-8S irashobora gukoreshwa kuburugero rufite ububobere burenze cyangwa bungana na 100Pa · s, cyangwa izindi viscosimeter zujuje ibyangombwa) yakoreshejwe kuri 20 ℃ ± 0.1 ℃, igenwa hakurikijwe amategeko (uburyo bwa kabiri bwa ⅵ G ku mugereka wa II wa Pharmacopoeia 2010).Niba ikirango cyanditseho kiri munsi ya 600mPa · s, ubwiza bugomba kuba 80% ~ 120% byanditseho ububobere;Niba ikirango cyanditseho ubunini burenze cyangwa bungana na 600mPa · s, ibishishwa bigomba kuba 75% kugeza 140% byanditseho ububobere.

3 Ikintu kidashonga mumazi
Fata 1.0g y'ibicuruzwa, ubishyire muri beaker, ongeramo amazi ashyushye 100mL kuri 80-90 ℃, ubyimba iminota igera kuri 15, ubikonje mu bwogero bwa barafu, ongeramo amazi 300mL (nibiba ngombwa, ongera amazi neza uko bikwiye menya neza ko igisubizo cyayunguruwe), hanyuma ukangure byuzuye, uyungurure unyuze oya.Ikirahure 1 gihagaritse gushonga cyumye cyumye kugirango gihore kuri 105 ℃, kandi usukure amazi.Amazi yayungurujwe mu kirahure cyo hejuru cyo gushonga hejuru yikirahure kandi yumishwa kugeza uburemere bwa 105 ℃, ibisigisigi bisigaye ntibirenza 5mg (0.5%).

4 Kugabanuka ibiro
Fata iki gicuruzwa hanyuma ukumishe kuri 105 ℃ mumasaha 2, kandi kugabanya ibiro ntibishobora kurenga 5.0% (Umugereka ⅷ L, Igice cya II, Pharmacopoeia 2010 Edition).

5 Gutwika ibisigazwa
Fata 1.0g yibi bicuruzwa hanyuma ubigenzure ukurikije amategeko (Umugereka ⅷ N, Igice cya II cya pharmacopoeia 2010 Edition), kandi ibisigisigi ntibishobora kurenga 1.5%.

Icyuma kiremereye
Fata ibisigisigi bisigaye munsi y ibisigara byaka, genzura ukurikije amategeko (uburyo bwa kabiri bwumugereka ⅷ H wigice cya kabiri cyigitabo cya farumasi 2010), kirimo ibyuma biremereye ntibishobora kurenga ibice 20 kuri miliyoni.

Umunyu wa arsenic
Fata 1.0g yiki gicuruzwa, ongeramo 1.0g calcium hydroxide, vanga, ongeramo amazi kugirango ubyuke neza, byumye, ubanza hamwe numuriro muto kugirango karubone, hanyuma kuri 600 ℃ gutwika ivu rwose, gukonjesha, kongeramo aside 5mL hydrochloric na 23mL amazi gusesa, kugenzura ukurikije amategeko (2010 Edition ya pharmacopoeia ii Umugereka method J uburyo bwa mbere), igomba kubahiriza ibiteganijwe (0.0002%).

Kwiyemeza ibikubiyemo
1, imikorerexyl
Methoxy, ethoxy na hydroxypropoxy (umugereka wa VII F, Igice cya II, 2010 Edition ya Pharmacopoeia).Niba hakoreshejwe uburyo bwa kabiri (volumetric method), fata ibicuruzwa, bipime neza kandi ubipime ukurikije amategeko.Ingano yimikorere yapimwe (%) ikurwa mubicuruzwa bya hydroxypropoxy (%) na (31/75 × 0.93).
2, hydroxypropoxy
Methoxy, ethoxy na hydroxypropoxy (umugereka wa VII F, Igice cya II, 2010 Edition ya Pharmacopoeia).Niba uburyo bwa kabiri (uburyo bwubunini) bwakoreshejwe, fata ibicuruzwa hafi 0.1g, upime neza, umenye ukurikije amategeko, hanyuma ubone.

Farumasi nuburozi
Hydroxypropyl methyl selulose ni igice cya methyl selile na igice cya hydroxypropyl ether, irashobora gushonga mumazi akonje kugirango ibe igisubizo kiboneye, imiterere yacyo n'amarira mubintu bya viscoelastique (cyane cyane mucin) hafi rero, birashobora gukoreshwa nkibihimbano amarira.Uburyo bwibikorwa ni uko polymer yumira hejuru yijisho binyuze muri adsorption, yigana ibikorwa bya mucin conjunctival mucin, bityo bikazamura imiterere yo kugabanya imisemburo ya ocular no kongera igihe cyo kugumana amaso mugihe cyo kugabanya amarira.Iyi adsorption ntabwo yigenga kubwiza bwigisubizo bityo ikemerera ingaruka zihoraho ndetse no kubisubizo byo hasi.Mubyongeyeho, guhanagura kwa corneal byiyongera mukugabanya guhuza Inguni yubuso bwa corneal.

farumasi
Nta makuru ya farumasi yigeze atangazwa kugirango akoreshe ibicuruzwa.

ibimenyetso
Ihanagura amaso ukoresheje amarira adahagije kandi ukureho kutamererwa neza.

Ikoreshwa
Yaba mukuru ndetse nabana barashobora kuyikoresha.Ibitonyanga 1-2, inshuro eshatu kumunsi;Cyangwa nkuko byateganijwe na muganga.
Ingaruka mbi zo guhindura imvugo
Mubihe bidasanzwe birashobora gutera uburibwe bwamaso nko kubabara amaso, kutabona neza, guhuzagurika kwa conjunctival cyangwa kurwara amaso.Niba ibimenyetso byavuzwe haruguru bigaragara cyangwa bikomeje, hagarika gukoresha ibiyobyabwenge hanyuma ujye mubitaro kwisuzumisha.
kirazira

Kwanduza abantu allergic kubicuruzwa.

Ibintu bikeneye kwitabwaho
1. Ntukore ku icupa ryumutwe kumutwe no mumaso kugirango wirinde kwanduza
2. Nyamuneka nyamuneka urinde ibicuruzwa kutagera kubana
3. Ukwezi kumwe nyuma yo gufungura icupa, ntibikwiye gukomeza kuyikoresha.
4. Imiti ku bagore batwite n'abonsa: nta raporo y’ibyangirika by’imyororokere cyangwa ibindi bibazo byatewe na selile ya HYDROXYpropyl mu mubiri w’umuntu yabonetse;Nta ngaruka mbi zigeze zigaragara ku bana bato igihe bonsa.Kubwibyo, nta kwanduza bidasanzwe kubagore batwite n'abonsa.
5. Imiti kubana: ugereranije nandi matsinda yimyaka, hydroxypropyl methylcellulose mubana ntabwo itera ingaruka mbi.Kubwibyo, abana nabakuze barashobora gukoresha iki gicuruzwa bakurikije gahunda imwe.
6, imiti kubasaza: gukoresha hydroxypropyl methylcellulose kubarwayi bageze mu zabukuru, ugereranije nandi matsinda yimyaka, ntabwo bitera ingaruka zitandukanye cyangwa ibindi bibazo.Kubwibyo, imiti yumurwayi ukuze ntabwo igabanya ubukana bwihariye.
7, ububiko: ububiko bwumuyaga.

Imikorere yumutekano
Kubangamira ubuzima
Iki gicuruzwa gifite umutekano kandi ntigifite uburozi, kirashobora gukoreshwa nkibiryo byongera ibiryo, nta bushyuhe, nta kurakara kuruhu na mucous membrane.Mubisanzwe bifatwa nkumutekano (FDA1985).Ibiryo byemewe buri munsi ni 25mg / kg (FAO / OMS 1985).Ibikoresho byo gukingira bigomba kwambarwa mugihe gikora.

Ingaruka ku bidukikije
Irinde kwanduza ikirere biterwa no kuguruka.
Ibyago byumubiri nubumara: irinde guhura ninkomoko yumuriro, kandi wirinde gukora umukungugu mwinshi ahantu hafunze kugirango wirinde ingaruka ziturika.
Ibikoresho byoherejwe
Witondere kurinda izuba imvura nubushuhe, irinde urumuri rwizuba, rufunze ahantu humye.
Ijambo ry'umutekano
S24 / 25: Irinde guhura nuruhu n'amaso.
Irinde guhura n'uruhu n'amaso.


Igihe cyo kohereza: Ukuboza-02-2021