Hpmc ni iki?

HPMC HydroxyPropyl MethylcellPllse, uzwi kandi nka Hypromellose, nimwe muri selile itari ionic ivanze bavanze ba leta. Nibisanzwe, polymer polymer, vielomes isanzwe ikoreshwa nka lubricant mumaso ya ophthalmology, cyangwa nkibyabaye cyangwa ibisebe mumiti yo mumvugo.

Izina ryibicuruzwa HydroxyPropyl Methyl Cellulose (HPMC)
Izindi zina HydroxyPropyl Methylcellllse, MHPC, Methyl HydroxyPropyl Cellulose
Kwohereza Kas 90045-3-3
Kugaragara Ifu yera cyangwa granular ifu
Ibisobanuro byumutekano S24 / 25

Imiti yumubiri na shimi
Kugaragara: cyera cyangwa hafi yera ifu ya fibrous cyangwa granular
Guhagarara: ibinini byaka kandi bidahuye ninzoga zikomeye.
Granularity; Igipimo cya metero 100 mesh kurenza 98.5%. Igipimo cyamaso 80 ni 100%. Ingano idasanzwe yubunini 40 ~ 60 mesh.
Ubushyuhe bwa karubone: 280-300 ℃
Ubucucike bugaragara: 0.25-0.70g / cm3 (mubisanzwe hafi 0.5g / cm3), imbaraga zihariye 1.26-1.31.
Ibara rihindura ubushyuhe: 190-200 ℃
Impagarara Zibi: 42-56dyne / cm muri 2% yo gukemura
Gukemurwa: gushonga mumazi hamwe na socieven, nkurwego rukwiye rwa ethanol / amazi, poronwanol / amazi, nibindi Gukorera mu mucyo, imikorere ihamye, ibisobanuro bitandukanye byibicuruzwa ubushyuhe bwa gel buratandukanye, umuco mubintu byinshi, umuti wa HPMC mumazi ntabwo yibasiwe na PH agaciro.
Igikorwa cyo hejuru cya HPMC cyagabanutseho kugabanuka kwibirimo, kwiyongera kwa gel no kugabanuka k'amazi.
HPMC ifite kandi ubushobozi bwo kwiyongera, kurwanya umunyu ihanagura invuta yifu, imbaraga za phi, gushikama kwurwego, gushiraho firime nziza, kimwe no gutandukana kwa enzyme, gutandukana no guhuza imiti.

Uburyo bwo gutanga umusaruro
Ipamba itunganijwe ifitanye isano na Lye kuri 35-40 ℃ ku gice cya kabiri cy'isaha, ikanda, ikanda, kugira ngo urwego rw'inkoko ya Alkali Fibre yabonetse ari mu ntera isabwa. Shira fibre ya alkali muri kattle yabayeho, ongeraho imyanda ya proplene na methane chloride ikurikiranye, etileze kuri 50-80 ℃ kuri 5h, igitutu kinini ni hafi 1.8Ma. Noneho ongeraho umubare wa Hydrochloric Acide na Oxalic acide acide muri 90 ℃ amazi ashyushye kugirango yagurize amajwi. Iyo amazi akubiye mubikoresho ari munsi ya 60%, yumye kugeza munsi ya 5% numwuka ushushe kuri 130 ℃. Hanyuma, ibicuruzwa byarangiye byajanjaguwe kandi bigenzurwa na mesh 20.

Uburyo bwo kuvura
1, moderi zose zirashobora kongerwaho ibikoresho byumye.
2, ukeneye kunonwa mu buryo butaziguye igisubizo gisanzwe cy'ubushyuhe, nibyiza gukoresha amazi akonje, nyuma yo kongeramo muri rusange muminota 10-90 kugirango ubyimbye.
3. Moderi isanzwe irashobora gushonga nyuma yo kuvanga no gutatana n'amazi ashyushye kandi yongeraho amazi akonje nyuma yo gukangura no gukonjesha.
4. Iyo gushonga, niba ibintu bya bibaye bibaye, ni ukubera ko kuvanga bidahagije cyangwa bisanzwe byongewe mumazi akonje. Muri iki gihe, bigomba gusuzumwa vuba.
5. Niba ibibyimba bibaye mugihe cyo guseswa, birashobora gukurwaho bahagaze mu masaha 2-12 (igihe cyihariye giterwa no guhuza igisubizo) cyangwa mugukangurira no gukatirwa amafaranga akwiye.

HPMC ikoresha
Byakoreshejwe nka Thickener, ikwirakwizwa, binder, byimazeyo, gukingirwa kwa peteroli, filler, Emalifier na stabilizer mu nganda. Ikoreshwa cyane muri synthectic resin, petrochemical, ceramic, impapuro, uruhu, imiti, ibiryo nibindi nganda.

Intego nyamukuru
Inganda 1, Kubaka: Mugihe ya CEVE ITANGAZO RY'AMAZI YAFATANYIJE, MOVARDER MORTAR YO KUBONA. Muri plastersing, Gypsum, ifu ya Putty cyangwa Ibindi bikoresho byubaka nkibifatika, binoza Daub no kuramba igihe. Ikoreshwa mu kurambura Ceramic Tile, marble, imitako ya plastike, paste ishimangira umukozi, aracyashobora kugabanya imiyoboro ya sima. Imikorere yo kugumana amazi ya HPMC ituma nyuma yo gusaba ntagomba kubera gukama byihuse no gucamo, kuzamura imbaraga nyuma yo gukomeza imbaraga.
2, inganda ceramic: ikoreshwa cyane nko gufata neza ibicuruzwa bya ceramic.
3, gupakira inganda: mu nganda zo gupfuka nk'igituba, ntapatanye kandi ucogora, mu mazi cyangwa ibiti byamazi bifite ibyokuntu byiza. Nkumusiga.
4, Ink Icapiro: Muri inganda za ink nkumubyimba, ukwirakwiza kandi uhagaze, mumazi, mumazi meza afite umuco mwiza.
5, plastiki: Kurema umukozi urekura, softener, amavuta, nibindi
6, PVC: Umusaruro wa PVC nkikwirakwizwa, guhagarikwa ubuhanga bwa PVC Aduliaimari.
7, inganda za farufe: Ibikoresho byo kuhira; Ibikoresho bya membrane; Ibikoresho byagenzuwe na polymer kubitegura harahamye; Umukozi uhamye; Imfashanyo zahagaritswe; Tablet ifatika; Yongera goo
8, abandi: na bo bakoreshwa cyane mu ruhu, inganda zitanga impapuro, imbuto n'imbuto n'inganda n'inganda.

Porogaramu yihariye

Inganda zubwubatsi
1, Centriment Mortar: Gutezimbere gutatanya sima - Umucanga, kunoza cyane plakiyeri no kugumana amazi, kugirango wirinde ibice bigira ingaruka, birashobora kongera imbaraga za sima.

2, Ceramic Tile Corse: Itezimbere plastike ya ceramic tile minile, kugumana amazi, kunoza imyigaragambyo ya ceramic tile, irinde ifu.
3, Asibesitosi hamwe nizindi ndwara yo kunonosora: Nkabakozi bahagaritswe, umukozi ushinzwe iterambere, ariko nanone kunoza ishingiro rya relay ya kole.
4, Gypsum Slurry: Gutezimbere kugumana amazi no gutunganya, kunoza amahano ya shingiro.
5, sima huje hamwe: ongeraho inama ya Gypsum hamwe na sima, kuzamura amazi no kugumana amazi.
6, Lapx Putty: Kunoza amazi no kugumana amazi ya resin ashingiye.
7, minisiteri: nkumusimbura wa paste karemano, urashobora guteza imbere kugumana amazi, kunoza imyigaragambyo ya kole hamwe na shingiro.
8, gukinisha: Nka plastisar ya latex, ifite uruhare mugutezimbere imikorere yakozwe n'amazi yo gupfuka no guhatanira ifu.
9, kwisiga
10, sima, ibicuruzwa byisumbuye by Gypsum: Nkuko byanditswemo - asibesitosi n'ibindi bikoresho bya hyseulic byerekana kubumba bunder, komeza amazi, ushobora kubona ibicuruzwa bimwe.
11, urukuta rwa fibre: Kubera ingaruka zo kurwanya enzyme kurwanya bagio-bacteri, nkuko binder byurukuta rwumucanga rufite akamaro.
12, Ibindi: Birashobora gukoreshwa nka minisiteri yoroheje ya minisiteri hamwe nuruhare rwa minisiteri rwabakozi ba minisiteri

Inganda za shimi
1, vinyl chloride, vinymel poléization: Nka stabilizeri yo guhagarika, ikwirakwizwa na vinyl inzoga za vinyl (pva) hydroxyPropyl selile ya selile (HPC) kandi irashobora kugenzura ikwirakwizwa ryimiterere ningingo.
2.
3. Uwica udukoko: yongeweho udukoko nimbuto, birashobora kunoza ingaruka zifatika mugihe utera.
4, nyakwigendera: Kunoza Emphalt Empilsion Stabilizer, Stryrene Butadiene Rubber (SBR) yatinze.
5, binder: nk'ikaramu, crayon ikora ibifatika.

Inganda zo kwisiga
1. Shampoo: Gutezimbere viscosity no gutuza ibituba bya shampoo, ibikoresho byogereza no gutanga ibikoresho.
2. Amenyo yometseho: Gutezimbere amazi yo amenyo.

Inganda
1, Citrus citrus: irinde kubungabunga kubera kubora glycoside ya orange no kwera metorphism kugirango tugere ku gishya.
2, Ibicuruzwa bikonje bikonje: Ongeraho mukime cyerekana, icyuma gisobanura neza.
3, isosi: Nka sosi, isosi ya inyanya itera stabilizer cyangwa umukozi wijimye.
4, amazi akonje ahinga glazing: ikoreshwa mububiko bwamafi bukonje, burashobora gukumira ibara ryiza, kugabanya ubuziranenge, hamwe na methyl selile ya selile methyl methyl methyl methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Methyl Mething
5, ibifatika byibinini: Nkimiterere yibinini n'ibinini, guhuza no gusenyuka (gushonga vuba no gutatana mugihe ufata) nibyiza.

Inganda za farumasi
1. Guhimbaza: Umukozi wo gutora akozwe mu gisubizo kama cyangwa igisubizo cy'amazi y'ibisate, cyane cyane ku bice bikozwe mu guhiga.
2, gahoro gahoro: garama 2-3 kumunsi, buri gihe 1-2G dosage, muminsi 4-5 kugirango yerekane ingaruka.
3, imiti yijisho: Kuberako igitutu cya osmotike cya hydroxypropyl methyl churlose igisubizo cyamazeri ari kimwe, ongeraho imiti yijisho, nkamavuta yo guhamagara lens yijisho.
4, umukozi wa gelatinous: Nkibikoresho byibanze byubuvuzi bwa gelatinonous hanze cyangwa amavuta.
5, Integnoning ibiyobyabwenge: Nka magent yijimye, ushinzwe kugumana amazi.

Inganda
1, ibikoresho bya elegitoroniki: mugihe cyamashanyarazi ya ceramic, bauxite Ferrite magnetic igitutu cyabujijwe
2, glaze: ikoreshwa nka ceramic glaze hamwe na porcelain hamwe na enamel, irashobora kunoza guhuza no gutunganya.
3, minisiteri yoroshye: ongeramo kuri minisiteri yo kumvikana cyangwa gutanura, birashobora kuzamura plastike no kugumana amazi.

Izindi nganda
1, fibre: Nkuko gucapa kuri doye paste, amafoto ya Boron, amarangi ashingiye ku munyu, imyera yimyenda, mubyose, muri Kapok yo gutunganya, irashobora gukoreshwa hamwe nubushyuhe bukomeye.
2, impapuro: ikoreshwa mumpapuro za karuboni zingana no gutunganya amavuta nibindi bice.
3, uruhu: Nkibyifuzo byanyuma cyangwa bikoreshwa nabi.
4, wino ishingiye ku mazi: wongeyeho wino ishingiye ku mazi, wino, nk'umukozi wijimye, umukozi ushinga filime.
5, itabi: Nkibikorwa by'itabi zisubirwamo.

Pharmacopoeia

Inkomoko n'ibirimo
Iki gicuruzwa ni 2- hydroxyPropyl ether methyl selile. HydroxyPropyl methylcellse irashobora kugabanywamo ubwoko bune ukurikije ibikubiye muri icyuma na hydroxyProppopyl, aribwo 1808, 2910.

imiterere
Ibicuruzwa ni byera cyangwa quib-yera-yera cyangwa granular ifu; Impumuro nziza.
Iki gicuruzwa kidasubirwaho muri anhydrol ethanol, ether na acetone; Kubyimba mumazi akonje kugirango ukore igisubizo gisobanutse cyangwa gito cya Twerloid.

Kumenya
. Shira 2ml yumuti mubizamini, Ongeraho 1ML wa 0.035% acthracene igisubizo cya acide, shyira muminota 5, hamwe nicyatsi kibisi hagati yimikoreshereze iri hagati yamazi abiri.
. Nyuma y'amazi, hashyizweho igice cya firime gikomeye.

kugenzura
1, PH
Nyuma yo gukonja, hindura igisubizo kuri 100g hamwe namazi hanyuma ukangurwa kugeza igihe bishonga rwose. Menya ukurikije amategeko (Umugereka ⅵ H, igice cya II ya Farumacopoe, 2010 Edition). Agaciro ka PH bigomba kuba 5.0-8.0.
2, viccosity
2.0% (G / G) yateguwe no gufata 10.0G y'ibicuruzwa no kongeramo 90 ℃ amazi yo gukora uburemere bwicyitegererezo n'amazi 500.0g nkibicuruzwa byumye. Guhagarikwa byari bitewe n'iminota 10 kugeza ku minota 10 kugeza igihe ibice byatatanye rwose kandi bitose. Guhagarikwa byakonje mu bwogero bwa barafu kandi nkomeza kubyutsa iminota 40 mugihe cyo gukonjesha. Umugereka umwe ruzunguruka (NDJ-1 rushobora gukoreshwa mu ngero zifite ubukuru munsi ya 100Pa · s, na NDJ Edition ya Pharmacopoeia 2010). Niba vicolity yanditseho iri munsi ya 600mpa · s, viscosity igomba kuba 80% ~ 120% ya vino yanditseho; Niba vicolity yanditse irenze cyangwa ingana na 600mpa · s, viscosity igomba kuba 75% kugeza 140% byanditseho vicosiya.

3 ibishoboka byose mumazi
Fata 1.0G y'ibicuruzwa, shyira mu ntera, ongeraho amazi ya 100m kuri 80-90, ukingure mu bwogero bwambaye ubusa, ongeraho amazi meza, hanyuma ukayungurura neza, ukayungurura muri oya. 1 Guhagarika ikirahuri Cyinshi Crumi cyumye uburemere buringaniye saa 105 ℃, kandi usukure inzoga n'amazi. Amazi yarushejwe mu kirahure cyavuzwe haruguru gishongeshejwe kandi yumye uburemere buringaniye kuri 105 ℃, hamwe nibisigara bisigaye bitarenze 5mg (0.5%).

Gutakaza ibiro 4
Fata iki gicuruzwa kandi ukayumisha saa 105 ℃ kumasaha 2, kandi kugabanya ibiro ntibishobora kurenga 5.0% (Umugereka wigice (Umugereka wa II, Edition ya Pharmacoeia 2010).

5 ibisigisigi byaka
Fata 1.0G yiki gicuruzwa hanyuma urebe ukurikije amategeko (Umugereka ⅷ n, igice cya II cya Pharmacopoeia 2010, kandi ibisigara bisinda ntibishobora kurenga 1.5%.

Ibyuma 6 biremereye
Fata ibisigisigi bisigaye munsi ya incandescent, reba ukurikije amategeko (uburyo bwa kabiri bwumugereka ⅷ h ku gice cya kabiri cya Pharmacoeia), kirimo amashyamba aremereye ntashobora kurenga ibice 20 kuri miliyoni 20 kuri miliyoni.

Umunyu wa Arseni
Fata 1.0G yiki gicuruzwa, ongeraho 1.0G calcium hydroxide, ongeraho amazi yo gukandagira, hanyuma ukandemo aside ya 5ml. (0.0002%).

Kwiyemeza
1, uburyo
Uburyo, Ethoxy na HydroxyPropropoxy (Umugereka wa Vape F, Igice cya II, 2010 Edition ya Farmacopoeia) yariyemeje. Niba uburyo bwa kabiri (uburyo bwa repotrike) bukoreshwa, fata ibicuruzwa, upima neza kandi ugipime ukurikije amategeko. Uburyo bwapimwe (%) yakuwe mubicuruzwa bya hydroxypropoplexy (%) na (31/75 × 0.93).
2, HydroxyPropoxy
Uburyo, Ethoxy na HydroxyPropropoxy (Umugereka wa Vape F, Igice cya II, 2010 Edition ya Farmacopoeia) yariyemeje. Niba uburyo bwa kabiri (uburyo bwumubumbe) bukoreshwa, fata ibicuruzwa nka 0.1G, bipima neza, biko neza, no kubona.

Farumasi n'ubuhigi
HydroxyPropyl Methyl Cellulose ni igice cya Methisl nigice cya hydroxyProppopyl ether, kuburyo burashobora gushonga mumazi akonje (cyane cyane mucin) hafi ya artificielre. Uburyo bwo gukora nuko Polymer yubahiriza ijisho binyuze mumaso, bityo bigana imiterere ya Mucin yo kugabanya ibyatsi no kongera igihe cyo kugumana amaso no kugabanya kugabanuka kwamarira. Iyi absorption yigenga kuri viscosity yibisubizo bityo yemerera ingaruka zidasubirwaho ndetse no kubisubizo byo hasi. Mubyongeyeho, ubukorikori bwiyongereye bwongerewe kugabanya inguni yimibonano yubuso busukuye.

farumasikotics
Nta makuru ya farumacokine yavuzwe kugirango akoreshe neza iki gicuruzwa.

ibimenyetso
Hindura amaso hamwe no gusohora amarira adahagije no gukuraho kutoroherwa.

Imikoreshereze
Abakuze n'abana bombi barashobora kuyikoresha. 1-2 ibitonyanga, inshuro eshatu kumunsi; Cyangwa nkuko byateganijwe na muganga.
Ibisubizo bibi Guhindura Imvugo
Mubibazo bidasanzwe birashobora gutera impungenge nke nkibara ry'amaso, iyerekwa ryamaso, ubudahwema conjuncttion cyangwa kurakara. Niba ibimenyetso byavuzwe haruguru biragaragara cyangwa bihoraho, hagarika gukoresha ibiyobyabwenge hanyuma ujye mubitaro kugirango usuzume.
kirazira

Byagereranywa nabantu allergique kuriyi bicuruzwa.

Ibintu bikeneye kwitabwaho
1. Ntukore ku icupa ryamacupa ryerekezaga ryisoni nubundi buso bwo gukumira umwanda
2. Nyamuneka komeza ibicuruzwa bitagera kubana
3. Ukwezi kumwe nyuma yo gufungura icupa, ntabwo bikwiriye gukomeza kubikoresha.
4. Imiti yo gutwita no kubura abagore: Nta raporo zo kwangirika kw'imyororokere cyangwa ibindi bibazo biterwa na hydroxypropyl selile yabonetse; Nta myitwarire mibi yavuzwe mu mpinja mugihe cyo gusaka. Kubwibyo, nta buntu bwihariye bwo gutwita no kubura.
5. Imiti kubana: ugereranije nindi matsinda, hydroxyPropyl methylcellse mubana ntabwo itera reaction nyinshi. Kubwibyo, abana nabantu bakuru barashobora gukoresha iki gicuruzwa ukurikije gahunda imwe.
6, imiti kubasaza: Gukoresha HydroxyPropyl Methylcellse mu barwayi bageze mu zabukuru, ugereranije nizindi matsinda, ntabwo bitera ingaruka zitandukanye cyangwa ibindi bibazo. Kubera iyo mpamvu, imiti y'umurwayi wa Senimoni ntabwo ifite ubututsi budasanzwe.
7, ububiko: Kubika ishyari.

Imikorere y'umutekano
Ubuzima
Iki gicuruzwa gifite umutekano kandi kitari uburozi, gishobora gukoreshwa nkibiryo byongeweho, nta bushyuhe, nta kurakara kuruhu no mu muco bivuga. Muri rusange bifatwa neza (FDA1985). Gutanga buri munsi ni 25mg / kg (fao / ninde 1985). Ibikoresho byo kurinda bigomba kwambarwa mugihe cyo gukora.

Ingaruka y'ibidukikije
Irinde umwanda wo mu kirere uterwa n'umukungugu.
Ingaruka z'umubiri na shimi: Irinde guhura n'amasoko y'umuriro, kandi wirinde gushinga umukungugu munini mu rwego rufunze kugira ngo wirinde ibyago biturika.
Ububiko bwibintu byoherejwe
Witondere kurinda izuba n'imvura n'ubushuhe, irinde urumuri rw'izuba, ufunze ahantu humye.
Ijambo ry'umutekano
S24 / 25: Irinde guhura nuruhu n'amaso.
Irinde guhura nuruhu n'amaso.