Abatsinze imiti ni abababaye kandi bagebweho bakoreshwa mugukora no gutanga ibiyobyabwenge, kandi nibice byingenzi byimyiteguro ya farumasi. Cellulose Ether nkuko bikomoka kubikoresho bya polymer karemano, bifite ibiranga biodegrame, budasanzwe, nka selile ya selileymethyl methyrmethyl Methyl abababaye imiti. Kugeza ubu, ibyinshi mu bicuruzwa bya Cellulose yo mu ngo bikoreshwa mu gihe cyo hasi cyane, inganda zikenewe cyane, inganda zikeneye guhinduka no kuzamura, kuzamura ibicuruzwa byo hejuru.
Ibikorwa bya farumasi ya farumasi birashobora kuba binini
Abavandimwe ba farumasi bafite uruhare runini mugutezimbere no gutanga imiti yimyiteguro ya farumasi. Kurugero, mu myiteguro ihamye, ether ether hamwe nibindi bikoresho bya polymer byari bikoreshwa cyane, birekura imiyoboro ihamye, birekura imiyoboro ikomeza kurekura, birekura imiti ihamye. Muri iyi sisitemu, ether ether hamwe naya polymers muri rusange ikoreshwa nkuwatwaye ibiyobyabwenge kugirango akemure ibiyobyabwenge mumubiri mugihe runaka kugirango agere kuntego ifatika.
Dukurikije imibare y'ubujyanama ya Zhiyan n'ubushakashatsi, Ubushinwa bwashyizwe ku rutonde rw'ubwoko 500 b'abarinzi, ariko ugereranije na Amerika (ubwoko burenga 15000, ubwoko bwa farumasi mu Bushinwa ni binini. Byumvikane ko abanzi icumi ba farumasi bari mu isoko ry'Ubushinwa ni farumasi celartiule Gelatin Capsile, PVP, HPMC, HPCRY Glycol Methyl Methyl Methyl Methyl Methyl Methylese, HPC, ishami.
Bitandatuubwoko bwaselile etherinAbavandimwe ba farumasi
Ubusanzwe selile na selile ni umukozi wa alkali hamwe numukozi wa alkine mubihe bimwe na bimwe byo kwifata kugirango ubyare urukurikirane rwa selile, ni syrroxyl ethercoxcule itsinda ryitsinda ryigice cyangwa bisimburwa rwose nibicuruzwa. Uburenganzira bwa Cellulose bukoreshwa cyane muri peteroli, ibikoresho byubaka, amatara, imiti, imiti yose, mumirima yose, ibikoresho byose bya farumasi ni muburyo bwimiterere yinganda, hamwe nagaciro gakomeye. Bitewe n'ibisabwa bikomeye, umusaruro w'icyiciro cya farumasi nacyo biragoye, birashobora kuvugwa ko ubuziranenge bwibicuruzwa byimiti bishobora kwerekana imbaraga za tekiniki zakagari. Ubumwe bwa Cellulose busanzwe bukoreshwa nka Blocker, ibikoresho bya skeleton no kureba, bikozwe mubikoresho byo gufunga ibishushanyo, bikomeza gufunga microCapsule Ibikoresho bipakira ibikoresho bya microCapsiule, ibikoresho byakazi.
Sodium carboxymethyl selile
Sodiyumu Carboxymethyl Cellulose (CMC-NA) ni Umusaruro mwinshi kandi wa Dothes ya etherton, ikozwe mu ipamba, ibiti bya alloroacetike bikozwe muri selile. CMC-NA nubwoko bwa farumasi bukunze gukoreshwa, mubisanzwe bikoreshwa nkibyiciro byimyiteguro ikomeye hamwe na virusi iterabwoba, hamwe na matrix-igabanya amazi hamwe nibikoresho byo gukora firime. Muguhitamo buhoro (kugenzurwa) kurekura imyiteguro, akenshi ikoreshwa nkibikoresho bya firime kugirango birekure ibiyobyabwenge byintara no kurekura buhoro.
Usibye sodium carboxymethyl selilekile yabarizwa na farumasi, sodium carboxike carboxymethyl selileymethyl selile irashobora kandi gukoreshwa nka pharsipients. Crossbox Carboxymethyl selile ya selile (CCMC-NA) ni ibintu byamazi byemewe bya CARBoxymethyl selile. Umukozi wa Scant arashobora kuba plycol, andhydride ya sucydride, anhydride ya jalkic anhydride na adipic anhydride. Crossboxy Carboxymethyl selile yakoreshejwe nkumukozi usenyutse wibinini, capsules na granules mu myiteguro no kubyimba kugira ingaruka zo gusenyuka, kugereranya kwayo, imbaraga zikomeye zo gusenya. Ubushakashatsi bwerekanye ko impamyabumenyi ya sodium ya sodium yambukiranya carboxymethyl selilexymethyl irenze iyo sodioneymethyl na hydds microcrystalline nandi mashanyarazi.
Methyl selile
Methyl selile (MC) ni Twoliulose imwe Nyirizina Ether yakozwe mu ipamba n'ibiti by alkalisation, hashyizweho imitaza ya chloromentisation nibindi bikorwa. Methyl selile ifite amazi meza kandi arahamye muri pH amanota ya 2.0 ~ 13.0. Bikoreshwa cyane mubababayeho, ibinini bikabije, inshinge zidasanzwe, imyiteguro yo mu magambo, capsules yo mu kanwa, ihagarikwa ryaka, ibinini byo mu kanwa. Byongeye kandi, MC irashobora gukoreshwa nka gel ya gel yiteguye kwitegura, ibikoresho byo gufunga gastric, harakomeje-ibintu bya microcapsule, birekura ibikoresho byo gutwikira microcapsule, bikomeza-kurekura ibikoresho bya firime yibiyobyabwenge, nibindi
Hydroxypropyl methyl selile
HydroxyPropyl Methyl Cellulose (HPMC) ni selile ivanze ether ikozwe mu ipamba ikozwe mu ipamba n'ibiti by alkana, imiterere ya proloronehane. Nibintu bidasanzwe, bidafite uburyohe kandi bidafite uburozi, gushonga mumazi akonje na gelatinous mumazi ashyushye. HydroxyPropyl Methyl Cellulose ni Umusaruro wo murugo, dosiye nubwiza bwa selile bivanze muburyo bwihuse, nimwe mubarizwa cyane mu rugo no mumahanga, nkuko imiti yihangana ifite amateka agera kuri 50. Kugeza ubu, porogaramu ya HPMC igaragarira cyane mu bintu bitanu bikurikira:
Imwe ni nkumukozi wa dinder hamwe nuwasenyutse. HPMC nka binder irashobora gutuma ibiyobyabwenge byoroshye bitose, kandi amazi yacyo arashobora kwagura inshuro amagana, bityo irashobora kunoza cyane iseswa cyangwa kurekura ibinini. HPMC ifite ubutwari bukomeye, kubwimiterere yibikoresho byangiza cyangwa bikomeretsa birashobora kuzamura urujijo rwayo, kunoza ubushake. HPMC viscosity yo hasi irashobora gukoreshwa nkabakozi bahuza kandi basenyuka, viscozeri yisumbuye gusa nkirubatse.
Iya kabiri ni nkibikoresho bitinda kandi bigenzurwa kugirango witegure umunwa. Hpmc ni ibikoresho bya hydrogel bikunze gukoreshwa muburyo burambye. HPMC ifite urwego ruto rwa virusi (5 ~ 50MPA · s) rushobora gukoreshwa nko kumenza urugero, ubufasha bwabakozi butemewe. HPMC irashobora gushonga mumazi ya gastric yinjira, afite ibyiza byingutu, amazi meza nibiranga ibiyobyabwenge byibasiwe na PH, kandi bikoreshwa mugutegura ibiyobyabwenge birekura, kandi bikoreshwa mugutegura ibiyobyabwenge birekura, kandi bikoreshwa mugutegura ibiyobyabwenge byaranze, kandi bikoreshwa mugutegura ibiyobyabwenge byaranze, kandi bikoreshwa mugutegura ibiyobyabwenge birerembaga, kandi bikoreshwa mugutegura amashanyarazi bireremba, umukinnyi wa firime abababaye.
Icya gatatu, nkumushinga wa firime - gushiraho umukozi. HPMC ifite film nziza ikora, ikora kimwe na film, mu mucyo, umusaruro ntushobora kunoza ubushuhe, ku buryo bworoshye bwo kunoza ubushuhe, kunoza uburyo bwo kwigunga bushobora guteza imbere ibiyobyabwenge, birinde gukomera kwa firime. HPMC ifite ibisobanuro bitandukanye bya virusiki, nko guhitamo neza, guhuza filime, isura iruta ibindi bikoresho, bikunze gukoreshwa muri 2% ~ 10%.
Icya kane ni nkibikoresho bya capsule capsule. Mu myaka yashize, hamwe no gutontoma kenshi icyorezo cyinyamanswa kwisi yose, ugereranije na Gelatin Capsules, capsules yibimera zabaye umukunzi mushya winganda. Pfizer yakuyeho HPMC yavuye mu bimera bisanzwe kandi yateguye VCCAPT ya VCAPTM. Ugereranije na Gelatin Hollow Capsules, Capsules yibimera ifite ibyiza byo guhuza n'imihindagurikire y'ikirere, nta kamba uhurira hamwe no gutuza cyane. Igipimo cyo kurekura ibiyobyabwenge kirahagaze neza, itandukaniro rya buri muntu ni rito, kandi ntabwo bashishikajwe no gusenya mu mubiri w'umuntu, kandi birashobora gusezererwa mu mubiri. Kubijyanye n'imiterere y'ibiryo, binyuze mu mubare munini w'ubushakashatsi, capsules ntabwo ihinda umushyitsi ihindagurika, kandi imitungo ya capsules iracyafite ubukonje bukabije, kandi indangagaciro za capsules zirimo ubukonje bukabije. Hamwe no gusobanukirwa n'abantu ba Capsules y'ibimera, ndetse no guhindura imyumvire y'ibiyobyabwenge rusange mu rugo no mu mahanga, gusaba capsules y'isoko bizakura vuba.
Bitanu ni nkumukozi wahagaritswe. Imyiteguro y'amazi yahagaritswe ikoreshwa mu rwego rwo gutanga dosiye, zikaba sisitemu yo gutatanya uburyo bwo kudahungabanya ibiyobyabwenge bidahwitse mu bitangazamakuru byo gutangiza amazi. Guhagarara kuri sisitemu bigena ubwiza bwahagaritswe. Igisubizo cya FPRC gishobora kugabanya impagarara zikomeye-zisungantego, kugabanya imbaraga zubusa zingingo zikomeye, kugirango sisitemu yo gutatanya hitera imbaraga, kuburyo sisitemu yo gutatanya kw'agaciro ikunda guhagarara, ni umukozi mwiza wo guhagarikwa. HPMC ikoreshwa nkuwigeze itonyanga yijisho, kandi ibirimo ni 0.45% ~ 1.0%.
Hydroxypropyl selile
HydroxyPropyl Cell Soleulose (HPC) ni colkele imwe ya selile yakozwe kuva ipamba nigiti na alkaliation, propaylene idahwitse nibindi bikorwa. HPC isanzwe ikundwa mumazi munsi ya 40 ℃ na numero nyinshi ya polar. Imitungo yayo ifitanye isano nibiri muri hydroxyproppopyle nurwego rwa polymeri. HPC irashobora guhuza nibiyobyabwenge bitandukanye kandi ifite inertia nziza.
Hasi ya HydroxyPropyl Trapleapyl Cellulose (L - HPC) kubinyuranye na tablet, biracyabitangaza, cyane cyane kubimburira ibinini, cyane cyane kubikorwa bya firime, cyane cyane bidashoboka ko film, bikaba byoroshye kubumba ingaruka zo gukiza.
Hejuru ya HydroxyPropyl Traleulopyl Cellulose (H-HPC) irashobora gukoreshwa nka bunder kuri tablet, granule hamwe na granule nziza mumurima wa farumasi. H-HPC ifite filime nziza yo gukora firime, film yabonye irakomeye kandi iragenda, kandi irashobora kugereranwa na plastizi. Mu kuvanga nabandi bakozi bashinzwe kurwanya ubushuhe, imikorere ya firime irashobora kurushaho kunozwa, kandi bikunze gukoreshwa nkibikoresho byo gupfumba bya firime kubinini. H-HPC irashobora kandi gukoreshwa nkibikoresho byo gutegura ibinini byakomeje-birekura ibinini, bikureho pellet hamwe na pallets ebyiri hamwe na laser-larete.
Hydroxyyeryl selile
Hydroxyyeryl selile (hec) ni ether imwe na selile imwe ikozwe mu ipamba n'ibiti by alkana, etylene okide irahinduka nibindi bikorwa. HEC ikoreshwa cyane cyane nka Thickener, umukozi wa Colloidal, acomera, atarasa, stabilizer, umukozi uhagaze, umukozi ushinga amagereza nibikoresho bihamye mubuvuzi. Irashobora gukoreshwa mu kumara ibiyobyabwenge byaho, amavuta, ibitonyanga by'amaso, ibinini byo mu kanwa, ibinini bikomeye, capsules nubundi buryo bwo gutanga dosiye. HydroxyAythyl Selile yashyizwe muri Pharmacopoeia Leta zunze ubumwe z'Amerika na Amerika na Pharmaine y'igihugu ndetse na Farumaniya.
Ethyl selile
Ethyl selile (EC) nimwe mubintu byakoreshejwe mumazi-bidahwitse. EC ntabwo ari uburozi kandi ihamye, ihungabanye mumazi, acide cyangwa ibisubizo bya alkali, gukosora muri ethanol, methanol hamwe nibindi bilime. Ibicuruzwa bisanzwe ni Toluene / Ethanol kuvanga 4/1 kuburemere. EC ifite byinshi mubiyobyabwenge bigenzurwa nibiyobyabwenge, bikoreshwa cyane nkumutwara wagenzuwe na micro caprane, bikoreshwa nkibikoresho bya skeleton, bikoreshwa nkibikoresho bya skeleton, bikoreshwa nkibikoresho byo gupakira Buhoro buhoro kurekura micro capsule; Irashobora kandi gukoreshwa cyane nkibikoresho bitwara kugirango bitegure ibice bikomeye. Bikoreshwa cyane mubukoranabuhanga bwa farumasi nka firime ikora ibintu nuburiganya, kimwe na binder na filler. Nk'inkoni yo gukingira ibinini, irashobora kugabanya kumva ibinini byubushuhe no gukumira ibiyobyabwenge ingaruka zijimye kandi zikumirwa. Irashobora kandi gusohora kurekurwa cyane kandi ugashyiraho polymer hamwe na microcapsules, kugirango ingaruka zibi zishobore kurekurwa ubudahwema.
Tuzakuraho hagati - kandi porogaramu zigihe gito no guhinduka no kuzamura
Gushyira muri make, sodium-sodium ya sodium carboxymethyl, methyl selile ya selile, hydroxyPropy Capsule ibikoresho kandi bihagarikwa imfashanyo ikoreshwa mubarinzi b'ubutaka. Kureba isi, ibigo byinshi by'amahanga mu bihugu by'amahanga (Ubuyapani Shin-Etsu, muri Amerika DOT Impyisi na Ashland) Menya Isoko Rikorerwa ishoramari ry'imiti. Dow yatangaje ko bizamuka kwibanda ku bitera, ibikoresho no gukenera isoko ry'imiti y'Ubushinwa, ndetse n'imbaraga zayo zo kuzana ubushakashatsi hafi y'isoko. Igabana rya Cellulose ya DOW na Ibara ryamabara yigenga kubashinzwe kugenzurwa, hamwe n'abakozi barenga 1.200 n'ibigo byinshi by'ubushakashatsi bakorera abakiriya mu bihugu bigera kuri 160. Ashland afite ibikoresho byo gukora muri Beijing, Tiajin, Shanghai, Nanjahou, Kunshan na JiAgmen, kandi bashora mu bigo by'ubushakashatsi muri Shanghai na Nanjing.
Nk'uko urubuga rw'Ubushinwa rwa Ether Cother, muri 2017, umusaruro wo mu rugo wa selile wari toni 373.000, kandi umubumbe wo kugurisha wari toni 360.000. Muri 2017, ingano yo kugurisha ya Ioonic CMC 234,000, kugeza 18,61%. Ibicuruzwa bitari ionic hiyongereyeho HPMC (ibikoresho byubaka), HPMC (FPRC (HPMC (ibiryo), HPC, HPC, HPC, HPC, kuri HPC kandi yongera umusaruro no kugurisha. Ingoma yimbere ether yamaze imyaka irenga icumi mumyaka icumi, ibisohoka byahindutse icyambere kwisi, ariko ibyinshi byibicuruzwa bya selile byakoreshejwe cyane kugeza kumafaranga yo hasi, ntagaciro ntabwo ari hejuru.
Ibikorwa bitandukanye bya selile murugo no mumahanga, cyane cyane mugihe cyingenzi cyo guhinduka no kuzamura ibintu byinshi bishoboka, bikaba bihuje imbere mu nganda, kumenya iterambere ryinshi.
Igihe cyohereza: Jan-27-2022