Ni ubuhe bwoko bwa hpmc ya HPMC?

PH agaciro ka HPMC (HydroxyPropyl methylcellselse) biterwa nibitekerezo byayo mubisubizo, ubushyuhe, nubwiza kandi ubuziranenge bwamazi yakoreshejwe. Mubisanzwe, PH agaciro ka HPMC mubisubizo bitangaje biri hagati ya 5.0 na 8.0, bitewe nibiranga ivuka hamwe nibisobanuro byatanzwe nuwabikoze.

1. Imiterere y'ibanze ya HPMC
HPMC nigiterwa na selile itari ionic ikoreshwa mubice byimiti, ibiryo nibihingwa, hamwe na firime nziza, kubyimba. Ntabwo ari ionic, gushonga mumazi akonje ariko atari mumazi ashyushye, nigisubizo muri rusange kidafite aho kibogamiye cyangwa acide nkeya. Mu nganda Porogaramu, HPMC ikirwa neza kubera umutekano waryo kandi ugereranije ninzego zihamye.

2. PH amanota ya HPMC
Ukurikije amakuru ya laboratoire hamwe nubushakashatsi bwubucukuzi, PH agaciro ka HPMC muburyo buke-bworoshye (nka 1-2%) muri rusange hagati ya 5.0 na 8.0. Amabwiriza yibicuruzwa yatanzwe nuwabikoze mubisanzwe atanga PH SHAM kubakoresha kugirango yerekane mugihe cyiboneza. Kurugero, PH agaciro ka PH hamwe nibicuruzwa bimwe na bimwe bya HPMC muri 0.1% bitangaje bigera kuri 5.5 kugeza 7.5, ugereranije no kutabogama.

Igisubizo cyo hasi: Mugihe gito (<2%), PH agaciro ka HPMC nyuma yo gusesa mumazi muri rusange yegereje kutagira aho bihegamye.

Igisubizo kinini cyo kwibanda: Mugihe cyibanze, ubushyuhe bwo gukemura bwiyongera, ariko agaciro ka PH kiracyahindagurika muburyo bwo kutabogama.

Ingaruka z'ubushyuhe: Kudakemurwa na HPMC bigira ingaruka cyane kubushyuhe. Birashobora gushonga byoroshye mumazi akonje kandi yoroshye mumazi yo hejuru yubushyuhe. Mugihe utegura igisubizo cya HPMC, mubisanzwe birasabwa gukoresha amazi akonje kugirango wirinde impinduka zidashoboka ziterwa nubushyuhe bwinshi.

3. PH agaciro ph no guhindura ibintu
Mubisanzwe, mugihe cyo gukora no gukoresha, mugihe uhitamo PH agaciro ka HPMC Igisubizo cyamazema, after ya Qulibted PH ikoreshwa mugupima itaziguye. Ariko, ibintu bikurikira birashobora kugira ingaruka kubisubizo bipima:

Amazi meza: Amazi aturuka ahantu hatandukanye arashobora kuba arimo umunyu washongeshejwe, amabuye y'agaciro, nibindi, bigira ingaruka kubisubizo bya PH. Muri rusange birasabwa gukoresha amazi yigitereko cyangwa amazi yateje kugirango utegure igisubizo cya HPMC kugirango hamenyekane neza ibisubizo.
Igisubizo Cyimico: Isumbuye Yibanze kuri HPMC, urushaho hejuru yumuti, uzana ingorane zimwe na zimwe na ph gupima, ku buryo buke
Ibidukikije byo hanze: Ubushyuhe, Kalibration yo gupima ibikoresho, nibindi birashobora gutera phi gutandukana.

4. PH ibisabwa muri Scenarios ya HPMC
Iyo HPMC ikoreshwa mubiribwa nubuvuzi, gushikama no guhuza agaciro bigomba gusuzumwa. Kurugero, mububiko bwa farumasi hamwe nimyiteguro ya capsule, HPMC ikoreshwa nkububyimba, ihamye-kurekura ibikoresho nibikoresho byo kurekura, kandi phi ituje, kandi PH umutekano ni ukwitaho. Ibiyobyabwenge byinshi bigomba kurekurwa mubidukikije byegeranye cyangwa acide gato, bityo ph iranga hpmc ibereye cyane iyi ntego.

Inganda zibiribwa: Iyo HPMC ikoreshwa nkuwabyimbye kandi stilizer, mubisanzwe yizeye ko agaciro kayo kegereye kutagira uburyohe kugirango bidashishimura ibicuruzwa.
Inganda za farumasi: Mu bisafuro na capsules, HPMC ikoreshwa mu kugenzura irekurwa ry'ibiyobyabwenge, kandi harahamye phi ihamye yo kutabogama ifasha gukomeza ibikorwa by'ibiyobyabwenge.

5. Uburyo bwo Guhindura PH ya HPMC Igisubizo cya Aqueous
Niba agaciro ka PHMC yigisubizo cya HPMC kigomba guhinduka muburyo bwihariye, birashobora kuba byiza-bihurira no kongeramo aside cyangwa alkali. Kurugero, umubare muto wa Hydrochloric acide cyangwa sodium hydroxide igisubizo, ariko igomba kugenzurwa neza kugirango yirinde kurenza urugero cyangwa kugira ingaruka kumutekano wa HPMC.

PH agaciro ka HPMC mu gisubizo gitangaje muri rusange kiri hagati ya 5.0 na 8.0, cyegereye kutabogama. PH ibisabwa muburyo butandukanye bwa porogaramu birashobora kuba bitandukanye cyane, ariko mubisanzwe nta guhinduka bidasanzwe.