Ni ubuhe buryo bukwiye cyane bwa hydroxyproppopyl methylcellse?

HydroxyPropyl MethylcellAlose (HPMC) ni polymer ikoreshwa amazi yakoreshejwe cyane muri farumasi, kwisiga, ibiryo no kubaka. HPMC ifite imikorere yo kugenzura virusi, ihamye ku mayobera, kunoza ibintu byimiterere no kubyimba, ubushyuhe rero ni ikintu cyingenzi mubisabwa.

1. Ibiranga STCOSITION ya HPMC
Inyenyeri ya HPMC ifitanye isano rya bugufi nuburemere bwayo, urwego rwo gusimbuza (ni ukuvuga urwego rwo gusimbuza hydroxy osipropy na methyl), kwibanda kubindi. Muri rusange, ingano nini yuburemere bwa molekile, hejuru ya virusire yigisubizo cya HPMC. Mubyongeyeho, ibisubizo bya HPMC hamwe nurwego rwo hejuru rwubusimbuza rukunda kugira ubushyuhe bwo hejuru kuko urwego rwo gusimburwa rugira ingaruka kumiterere yumurongo wa molekile, igira ingaruka ku mikorere yonyine nubusa.

Ubusanzwe viscosity ya HPMC isanzwe ipimwa ku kigero runaka ukoresheje amashusho ya roshuriate. Ukurikije porogaramu ya HPMC, agaciro kagaragaye kasabwa nabyo biratandukanye.

2. Ibisabwa kuri HPMC vicosity muburyo butandukanye
Umurima wa farumasi
Mu nganda za farumasi, HPMC ikoreshwa kenshi gutegura ibisate, capsules, ibitonyanga by'amaso no kugenzurwa n'ibiyobyabwenge. Kubwo kwitegura ibinini na capsules, HPMC igira uruhare runini mumabwiriza yo kurekura ibiyobyabwenge nka firime yahoze ari film.

Kugenzurwa Imyiteguro yo kurekura: Kugenzurwa no kwitegura ibiyobyabwenge bisaba HPMC kugira ubukuru buciriritse. Muri rusange, viscosiya igisubizo cya HPMC kigomba kugenzurwa hagati ya 300 na 2000 MPA- ifasha kurekura ibiyobyabwenge birakomeza kandi bigenzurwa nibiyobyabwenge. Niba uruzitiro ari hejuru cyane, ibiyobyabwenge birashobora gusohoka buhoro; Iyo uruzitiro ruri hasi cyane, ingaruka zigenzurwa zibiyobyabwenge zirashobora guhungabana.

Ibitekerezo bya Tablet: Mugihe cyo kwikuramo ibinini bya tablet, visosity ya HPMC ifite uruhare runini kumwanya wa tablet hamwe nigihe cyo gusenyuka. Muri iki gihe, viscosity igomba kuba hagati ya 500 na 1500 MPAHE kugirango imenyesheho neza kandi imikorere myiza yo gusenyuka.

Umwanya w'ibiribwa
Mu nganda zibiribwa, HPMC ikoreshwa nkigituba na emalifiire mubicuruzwa nkibishusho, ice cream, n'ibinyobwa by'imbuto. Ibicuruzwa bitandukanye bifite ibisabwa bitandukanye kuri viscosity ya HPMC:

Ibinyobwa by'imbuto: Mu binyobwa by'imbuto, ubushyuhe bwa HPMC bugomba kugenzurwa hagati ya 50 na 300 MPA. Ubu buryo bwo hejuru cyane bushobora gutera ibinyobwa bishobora kuryoherwa cyane, bidafasha kwemerwa nabaguzi.

Ice cream: kuri ice cream, hpmc ikoreshwa mugutezimbere imiterere nuburyo bworoshye. Muri iki gihe, agaciro ka vino mubisanzwe gakeneye kugenzurwa hagati ya 150 na 1000 MPA- kugirango umenye neza ko ice cream ifite ubukana kandi ururimi rwiza rwumva.

Umwanya wubwubatsi
Mu nganda zubwubatsi, HPMC ikunze gukoreshwa mubikoresho byubaka nka sima, Gypsum na minisiteri. Uruhare rwa HPMC muri ibi bikoresho harimo cyane cyane kubyimba no kunoza amazi. Urutonde rwarwo rusanzwe rusanzwe, mubisanzwe 2000 kugeza 10000 mppa · ​​s. HPMC murutonde irashobora kunoza imikorere imikorere yubwubatsi yibikoresho byubwubatsi, nko kunoza ikibazo no kwagura igihe cyo gufungura.

Umwanya wo kwisiga
Mu murima wo kwisiga, HPMC ikunze gukoreshwa mu gushyiraho ibicuruzwa nko guhangayikishwa, amavuta, ibisigazwa, ubudakemwa, ibitagenda neza, ibibi, n'ibindi. Byinshi cyane birashobora gutera ikoreshwa ryibicuruzwa, bigira ingaruka kubakoresha uburambe.

3. Ibintu bireba viscosity ya HPMC
Uburemere bwa molekile: nini yuburemere bwa moleclar ya HPMC, igihe kinini urunigi rwa molekile, nicyo gihe hejuru cyane igisubizo. Kuri HPMC hamwe nuburemere bunini bwa molekile, viscosiya igisubizo cyacyo icyarimwe kwibandaho bizakururwa cyane kurenza ibya HPMC hamwe nuburemere buke bwa molecular. Kubwibyo, guhitamo HPMC hamwe nuburemere bukwiye bwa molekilar nurufunguzo rwo kuyobora viscosiya.

Urwego rwo gusimbuza: Urwego rwo gusimbuza HPMC, ni ukuvuga urwego rwo gusimbuza HydroxyPropy na Methyl, ruzagira ingaruka ku rubyiruko rwayo. Urwego rwo hejuru rwo gusimbuza ubusanzwe rutuma molekile ya HPMC ihamye neza, kandi imikoranire iri hagati ya molekiri iriyongera, bikavamo ubuyobe bwiyongera.

Igisubizo Cyimico: Kwibanda kubisubizo bya HPMC bifite uruhare runini kuri viscosiya. Muburyo buke, viscosiya igisubizo cya HPMC ni gito; Mugihe cyibanze, imikoranire hagati yiminyururu ya molekile yiyongera, kandi ubukuru bwiyongera cyane. Kubwibyo, mubikorwa bifatika, ubukuru bwibicuruzwa byanyuma birashobora kugenzurwa no guhindura imyumvire ya HPMC.

Ibicuruzwa n'ibidukikije: Kukeshanagurwa no gusya bya HPMC nabyo bifitanye isano rya bugufi n'ubwoko bw'ibidukikije (nka PH, ubushyuhe, n'ibindi). Ibitekerezo bitandukanye nubushyuhe butandukanye nibihe bya PH bizahindura ibibazo bya HPMC, bityo bigira ingaruka kuri viscosiya igisubizo cyayo.

Uruzinduko rwa HPMC nimwe mubipimo byingenzi mubikorwa byayo mubice bitandukanye. Muri farucetic, ibiryo, kubaka, kwisiga nizindi nganda, viscosity ya HPMC igomba kugenzurwa murwego runaka ukurikije ibisabwa bitandukanye. Muguhindura ibintu nkuburemere bwa molekile, urwego rwo gusimbuza, kwibanda no gukemura HPMC, victhity yayo irashobora kugenzurwa neza kugirango ikenerwe ibikenewe. Mubikorwa nyabyo, guhitamo vicosity kubisabwa byihariye bya porogaramu nurufunguzo rwo kwemeza ibicuruzwa n'imikorere.