Ni ubuhe bushyuhe bwa Gel bwa hydroxypropyl methylcellse?

Ubushyuhe bwa GelroxyPropyl Methylcellse (HPMC) ni ibipimo by'ingenzi mu nganda zitandukanye, harimo imiti, ibiryo, kwisiga, no kubaka. HPMC ni polymer ya kimwe cya kabiri ikomoka kuri selile, ikoreshwa cyane nkumubyimba, binder, kandi ikinyarwandanyishije porogaramu, ntabwo ari uburozi, hamwe numutungo wa filime.

Gusobanukirwa ubushyuhe bwa Gel bwa HPMC ni ngombwa kuko bigira ingaruka kuri viscosity, kwigira ingaruka kubikorwa bya gel bikoreshwa muri. Reka duhereze mu gitekerezo cya Gel

Ubushyuhe bwa gel ni iki?
Ubushyuhe bwa GAL bwa polymer bivuga ubushyuhe bukora gel kuri hydtion cyangwa gusesa muburyo bworoshye. Kuri HPMC, ubu ni ubushyuhe burimo iminyururu ya polymer yizirika kandi ikora umurongo wigipimo bitatu, biganisha kuri gel. Inzibacyuho kuva kumuti kuri Gelli ni ingenzi mubikorwa byayo muburyo butandukanye.

Ibintu bigira ingaruka ku bushyuhe bwa GPMC:
Urwego rwo gusimbuza (DS): Ubushyuhe bwa GPMC biterwa nurwego rwo gusimbuza amatsinda ya hydroxy ordroxyle na methyl. Mubisanzwe, DS hejuru ya DS iganisha ku bushyuhe bwo hasi.

Uburemere bwa MoleCular (MW): Ibiro byo hejuru bya molecular HPMC ikunda kugira ubushyuhe bwo hejuru bwa gel kubera ubwitonzi bwiyongera.

Kwibanda no kumuti: Ubushyuhe bwa Gel buterwa na HPMC yibanda kuri HPMC hamwe na kamere yo kumuti. Ibitekerezo byinshi hamwe nuduseke birashobora kugabanya ubushyuhe bwa gel.

Inzobere: Ongeraho umunyu, acide, cyangwa izindi polymers zirashobora guhindura imyitwarire ya pelelation ya HPMC.

PH: PH igira ingaruka kuri ionisation yimikorere kuri HPMC, nayo igira ingaruka kumyitwarire ya pelelation.

Kugena ubushyuhe bwa Gel:
Uburyo bwinshi bukoreshwa kugirango umenye ubushyuhe bwa GPMC:

Indorerezi ziboneka: Gukurikirana igisubizo gishakisha impinduka muri viscosiya cyangwa uhindagurika nkuko ubushyuhe buhinduka.

Ibipimo bya Rheologiya: Gukoresha Rheometer kugirango upime impinduka muri virusi cyangwa elastike modulus nkigikorwa cyubushyuhe.

Ububiko butandukanye bwo gusikana (DSC): Kumenya impimbano ya endotrac ihuye na Gel.

Turbidimetry: Gukurikirana umucyo wo gukemura igisubizo ukoresheje tekinike yo kohereza.

Akamaro mu nganda:
Farumasiti: Muri sisitemu yo gutanga ibiyobyabwenge, ubushyuhe bwa Gel bushingiye kuri HPMC bugena kurekura ibiyobyabwenge na gel imbaraga, bigira ingaruka kumikorere no gushikama kwa farumasi.

Inganda zibiribwa: HPMC ikoreshwa nkuwabyimbye, stabilizer, nuwagejejwe na felling mubicuruzwa. Ubushyuhe bwa Gel bugira ingaruka kumiterere, umunwa, no gutuza kwibiribwa.

Kwisiga: Ubushyuhe bwa Gel bugira ingaruka kumiterere yimiterere yo kwisiga, kugira uruhare rukomeye ibicuruzwa, gushikama, hamwe nibiranga.

Kubaka: Mubikoresho byubwubatsi nkibikoresho byo mubwubatsi no kumeneka, ubushyuhe bwa GPMC bugira ingaruka ku gikorwa, ishyiraho igihe, n'imbaraga za nyuma.

Ubushyuhe bwa Gel bwa hydroxypropyl methylcellse bigira uruhare runini mubikorwa byacyo hakurya yinganda zitandukanye. Gusobanukirwa ibintu bigira ingaruka kuri pelation no gukoresha tekinike yo gupima bikwiye ni ngombwa kugirango utezimbere ibicuruzwa no kwemeza ibintu byifuzwa. Nk'inganda zikomeje guhanga udushya, gukoresha ubushyuhe bwa GPMC bizaguma ahantu h'ubushakashatsi n'iterambere, iterambere ryo gutwara ibinyabiziga mubyiciro bitandukanye.