Methyl selile (MC) na HydroxyPropyl Methylcellus (HPMC) ni kogosha ibikomoka kuri selile kandi bikoreshwa cyane muri farumasi, ibiryo, ibikoresho byo kubaka nibindi bikoresho. Nubwo bombi bakomoka kuri selile karemano kandi bafite imirimo isa nibisabwa, bafite itandukaniro ryingenzi mumiterere yimiti, imitungo yumubiri, imirima isaba nibiranga imikorere.
1. Imiterere yimiti hamwe nuburyo bwo gutegura
Methyl selile (MC): Methyl selile ikorwa no gusimbuza igice cyangwa ibice byose bya hydroxyl (-Oh) bya selile hamwe na MethoXY (-OCH₃). By'umwihariko, amatsinda ya hydroxyl muri selile yiboneye methylating reagents (nka methyl chloride) mubihe bya alkaline kugirango birire methylcellse. Kubera impamyabumenyi itandukanye yo gusimburwa, MC irashobora kugira ibyokuntu bitandukanye no gusya.
HydroxyPropyl methylcellse (HPMC): HPMC irahindurwa hashingiwe kuri MC, ni ukuvuga muri molekile ya selile yasimbuwe nitsinda rya selile, ariko nanone igice cya molekile cyasimbuwe gusa nitsinda ryitsinda ryakarere (-ch₂chohch₃) Hydroxy. Gutegura HPMC birimo reaction yintambwe ebyiri: ubanza imyigaragambyo hanyuma hanyuma usabe imyuga. Kubera iki gusimburwa kabiri, imitungo ya HPMC iragoye kandi itandukanye.
2. Kudakemurwa no kuranga umubiri
Kukesha kwa MC: methylcellse ifite byinshi byonyine mumazi akonje, ariko ntabwo ashonga mumazi ashyushye. Igisubizo cyacyo kizatanga umusaya mugihe gishyushye, kituma MC ifite agaciro gakomeye gasaba mubikorwa runaka, nkibisabwa mubikoresho byubaka.
Kukesha agaciro hpmc: Ibinyuranye, HPMC irashonje mumazi akonje namazi ashyushye, nibisubizo byayo bifite uruzitiro rwagutse. Byongeye kandi, HPMC yerekana umutekano mwiza mubisubizo byateganijwe kandi ntabwo yunvikana impinduka muri PH agaciro, bityo birakoreshwa cyane mubintu byimiti nibiribwa.
3. Ahantu ho gusaba
Gusaba methycellsellse: Bitewe numubumbe wa TC, akenshi bikoreshwa nk'amazi agumana mu bubiko, cyane cyane muri cemer, n'ibindi bikorwa byo gufasha kunoza uburyohe no gutuza kw'ibiryo. Mu nganda za farumasi, MC rimwe na rimwe ikoreshwa nkumukozi ushyiraho ibinini nibikoresho byo gukora firime kuri capsules.
Gusaba HydroxyPropyl Methylcellse: HPMC irenze kuri MC mu nganda nyinshi kubera ubwitonzi bwayo butuje. Kurugero, HPMC ikoreshwa cyane mu nganda za farumasi kugirango itegure ibinini byagenzuwe na caple na capsule, ndetse no mubyiciro bya ophthalmic. Mu bikoresho by'ubwubatsi, HPMC ikunze gukoreshwa nk'abakozi bamazi n'amazi ya minisiteri, abashyiramo ibice no kugikora. Byongeye kandi, HPMC ikoreshwa kandi nkumunyengoma, emalifier na stabilizer mu nganda zibiribwa.
4. Ibiranga imikorere hamwe nibice byimikorere
Imikorere yimikorere ya MC: Ikintu cyihariye cya methycliulose nimitungo yacyo yubushyuhe, ituma igira ingaruka cyane mubisabwa bisaba umutekano wuzuye. Mubyongeyeho, igisubizo cyibiheza cya MC gifite urwego runaka rwimikorere no mubikorwa, bifitiye akamaro muburyo bumwe bwinganda.
Ibiranga Imikorere ya HPMC: HydroxyPropyl Methylcellllse irangwa no kugenzura ibibazo byo kwishyurwa no gukemura, hamwe nuburemere bwayo kubushyuhe na PH. Ibi biranga bituma HPMC igaragaza uburyo bukomeye no gutuza muburyo butandukanye. Byongeye kandi, bioquatishyo ya HPMC nuburozi butuma byingenzi cyane mubuvuzi nibiribwa.
5. Kurinda ibidukikije n'umutekano
Ibidukikije byangiza ibidukikije bya MC na HPMC: NKUKO BAKORANA NA COLLOSE, MC na HPMC nibikoresho bya biodegraduside kandi bifite ingaruka nke kubidukikije. Byongeye kandi, ibikoresho byombi ntabwo ari uburozi, butabangamiye kandi bifite umutekano cyane, bigatuma bakoresha mu turere dufite abantu benshi, nk'ibiryo n'imiti n'imiti.
Nubwo methycellsellse (mc) na hydroxyPropylmethylcellcellcellcellcellcellcellcells (HPMC) bafite ibintu bihuriye nububiko, umubyifuzo byabo, imitungo yumubiri, imitungo yumubiri, ibiranga imitungo biratandukanye bitewe nuwasimbuye bitandukanye. Hariho itandukaniro rikomeye. MC cyane cyane mu porogaramu zisaba imitungo ya selling, nko mu bikoresho byo kubaka; Mugihe HPMC ikoreshwa cyane muri farumasi, ibiribwa nibiribwa bitewe nubwitonzi bwayo bugari, umutekano nuburozi. Gusobanukirwa itandukaniro riri hagati yombi rirashobora kugufasha guhitamo ibikoresho bikwiye kugirango usabe.
Igihe cyagenwe: Gashyantare-17-2025