Ni irihe tandukaniro riri hagati ya HPMC na MC muri phargacetical Porogaramu?

HydroxyPropyl Methylcellsellse (HPMC) na methycellsellse (MC) ni kogorwa na selile zikoreshwa cyane cyane mubikorwa byimiti bitewe n'imitungo yabo itandukanye. Nubwo bahuriyeho, bafite itandukaniro ritandukanye mumiterere yimiti, imitungo, hamwe na porogaramu zituma ziba zikwiriye intego zitandukanye mumibonano mpuzabitsina.

Imiti n'imiterere
HydroxyPropyl Methylcellse (HPMC):

Hpmc ni umunyamategeko wahinduwe na selile. Bikomoka kuri selile mu kuyifata na methyl chloride na propantylene oxide, itangiza uburyo (-OCH3) na hydroxyPropyl (-ch2chohsPropyl (-ch2chohch3) Amatsinda muri selile. Urwego rwo gusimbuza (DS) hamwe no gusimbuza umuryango (MS) kumenya igipimo cyaya matsinda. DS yerekana impuzandengo yimibare ya hydroxyl yasimbuwe ku gice cya Anhydroblucose, mugihe ms yerekana impuzandengo yibigereranyo byimibare ya hydroxyPropyle.

Methylcellse (MC):

MC niyindi selile ether, ariko ntabwo yahinduwe ugereranije na HPMC. Ikozwe mu kuvura selile na methyl chloride, bikaviramo gusimbuza amatsinda ya hydroxyl hamwe na Methoxy. Iyi mpinduka ibarwa nurwego rwo gusimbuza (DS), kuri MC, mubisanzwe kuva 1.3 kugeza 2.6. Kubura amatsinda ya hydroxyPropyle muri MC itandukanya kuva HPMC.

Umutungo
Kukemeranya no gukekwa:

HPMC irashonje mumazi akonje namahoro, agize igisubizo cya colloidal. Amaze gushyushya, HPMC ihura na pelation yo mu mafarasi, bivuze ko ikora gel iyo ashyushye kandi ikemeza igisubizo ku gukonja. Uyu mutungo ni ingirakamaro cyane mu kurekurwa ibiyobyabwenge kandi nkuko bigaragara mu buryo bunoze mu buryo butangaje.

MC, kurundi ruhande, irashonga mumazi akonje ariko idashobora guke mumazi ashyushye. Irerekana kandi gukandagira; Ariko, ubushyuhe bwa pelale muri rusange burenze bwa HPMC. Ibi biranga bituma MC ibereye porogaramu yihariye ya farumasi aho ubushyuhe bwo hasi bwa gelala ari bwiza.

Vicosity:

HPMC na MC byombi birashobora kongera ubukwe bwibisubizo bitangaje, ariko hpmc muri rusange itanga ubushyuhe bwagutse kubera ibishushanyo mbonera. Itandukaniro rituma tugenzura neza muburyo busaba imyirondoro yihariye.

Imikorere muri farumasi
HPMC:

Kugenzurwa Amabwiriza ya Matrix:
HPMC ikoreshwa cyane igenzurwa yagenzuwe matrix. Ubushobozi bwayo bwo kubyimba no gukora urusaku rwa gel iyo duhuye namazi masambanyi afasha mugucunga igipimo cyo kurekura ibiyobyabwenge. Igipimo cya Gel gikora nkinzitizi, modulating ikwirakwizwa ryibiyobyabwenge kandi ikagura irekurwa.

IHURIRO RY'IMPIRO:
Bitewe na firime nziza ya firime, HPMC ikoreshwa cyane mugutwikwa ibinini hamwe na pellet. Itanga inzitizi yo kurinda ubushuhe, ogisijeni, n'umucyo, kuzamura umutekano n'ubuzima bw'amaso y'ibicuruzwa. Byongeye kandi, aho bireba birashobora gukoreshwa muburyohe bwo guhita no kunoza isura yibinini.

Binder muri Tablet forems:
HPMC nayo ikoresha nka binder muburyo butose granulation. Iremeza imbaraga zamashini yibisate, byorohereza guhuza ifu mugihe cyo kwikuramo.

Guhagarika no kwinginga:
Muburyo bwamazi, HPMC ikora nkigikoresho cyo guhagarikwa no kubyimba. Ubukwe bwabwo bukomeye bufasha mugukomeza ikwirakwizwa rimwe ryahagaritswe kandi ritezimbere guhuzagurika.

MC:

Tablet irahuza:
MC ikoreshwa nka bunder muri tablet. Itanga imitungo myiza nimbaraga zamanishi kubinini, kubungabunga ubunyangamugayo mugihe cyo gufata no kubika.

Gutandukanya:
Rimwe na rimwe, MC irashobora gukora nk'ibinini bisenyutse, ifasha ibinini byo gusenyuka mu bice bito bivugana n'amazi ya gastric, bityo korohereza kurekura ibiyobyabwenge.

Kugenzurwa Kurekura Imiterere:
Nubwo bidasanzwe kurenza HPMC, MC irashobora gukoreshwa mugusohora ibicuruzwa. Umutungo wacyo wacyo urashobora gukoreshwa kugirango ugenzure umwirondoro wibiyobyabwenge.

Kubyimba no guhaza ingufu:
MC ikoreshwa nkumuntu wijimye kandi uhamye mumazi atandukanye na kimwe cya kabiri. Ubushobozi bwayo bwo kongera virusi ifasha mugukomeza umutekano nubusabinyi bwibicuruzwa.

Porogaramu yihariye muri farumasi
Porogaramu ya HPMC:

Imyiteguro ya Ophthalmic:
HPMC ikoreshwa kenshi mubisubizo bya Ophthalmic na gels kubera umutungo wacyo uhigana nubusa. Itanga igumana ubushuhe kandi ikirangira igihe cyibiyobyabwenge hamwe nubuso bwa ocular.

Sisitemu yo gutanga Triserdermal:
HPMC ikoreshwa mububiko bwa transdermal aho ubushobozi bwaho bwo gukora firime bufasha mugushiraho matrix igenzurwa kugirango itange ibiyobyabwenge binyuze muruhu.

Umusemburo:
Imiterere ya Mucoadive ya HPMC ituma ikwirakwira kuri Bucbal, izuru, na hamwe na HASIGAL, hamwe no kuzamura igihe cyo gutura ahagenewe.

Porogaramu ya MC:

Ibigize byinshi:
MC ikoreshwa muri cream yiringo, gels, namavuta aho bikora nkumukozi wijimye kandi uhamye, utezimbere ikoreshwa ryibicuruzwa.

Ibiryo n'intungamubiri:
Hanze ya faruceuticals, MC isanga porogaramu mu biribwa n'ibikoresho by'utubatsi nk'igituba, Emalifier, na stabilizer, bigira uruhare mu miterere no gutuza kw'ibicuruzwa bitandukanye.

Muri make, HPMC na MC bombi bafite agaciro ka selile biranga ibintu bitandukanye bituma bikwiranye nibikorwa bitandukanye bya farumasi. HPMC, hamwe no kwikebagura ibintu bishyushye mumazi ashyushye kandi akonje, urujijo rwo hejuru, hamwe nubushobozi bwo gutondekanya firime, bitoneshwa cyane cyane kugenzurwa, ibisate bya tablet, hamwe nimyiteguro ya tablet. MC, mugihe cyoroshye mubigize, bitanga ibyiza byihariye mubintu bikonje hamwe nubushyuhe bwo hasi, bigatuma ari ingirakamaro nkumukozi uhuza. Gusobanukirwa itandukaniro mu nzego zabo, imitungo y'umubiri, n'imikorere yemerera abamubutso guhitamo ubugari bukwiye bwo kuzuza ibyifuzo byimiti byihariye bya farumasi.