Nibihe bikoresho fatizo bya hydroxypropyl methylcellse?

HydroxyPropyl methylcellse (HPMC) ni polymer itandukanye ifite porogaramu mu nganda zitandukanye, harimo imiti, kubaka, ibiryo no kwisiga. Ibikoresho fatizo bikoreshwa muri synthesis ya HPMC bivanwa muburyo busanzwe kandi bugatera urukurikirane rwibishushanyo mbonera kugirango ubone imitungo yifuzwa.

Cellulose: Ibyingenzi

Ibikoresho nyamukuru bya HPMC ni selile, karubone ikomeye yabonetse mu rukuta rw'ibimera. Ipamba na myiko ry'ibiti ni isoko rusange ya selile. Fibre ya Cellulose yafatwaga kugirango ikureho umwanda hanyuma igambiriye gusenya iminyururu ya selile muri polysaccharchaside ntoya. Inzira ikubiyemo gukoresha aside cyangwa imisemburo yo kwizirikana injyana ya glycosidic iri muri selile, bikaviramo iminyururu ngufi ya selile yitwa selile.

Poppeylene oxide: Kumenyekanisha hydroxyPropyl

Nyuma yo kubona selile ether, intambwe ikurikira ikubiyemo kumenyekanisha amatsinda ya hydroxyProppoyl muri selile ya selile. Poropaylene oxide nimboga yingenzi zikoreshwa kubwiyi ntego. Imbere ya alkaline catalyst, imyanda ya propalne yitabye amatsinda ya hydroxyl kumurongo wa selile, bikaviramo kwinjizwa mumatsinda ya hydroxyProppoyle. Iyi myitwarire, yitwa irahinduka, igira uruhare runini muguhindura umubiri nuburozi bwa selile, itanga hydroxyProppopyl selile.

Methyl chloride: ongeramo methyl itsinda

Mu ntambwe yo guhinduranya nyuma, methyl chloride ikoreshwa mu kumenyekanisha amatsinda ya methyl kuri selile. Iyi nzira, yitwa Methylation, ikubiyemo gufata selile hamwe na methyl chloride imbere yibanze. Amatsinda ya Methyl yongewe kuri HydroxyProppeplese kugirango ikore hydroxyPropylmethylmethylcellsLmethylcellsellsellse (HPMC). Urwego rwo gusimbuza (DS) rwerekana impuzandengo ya HydroxyProppopy na methyl gahunda ya glucose muri pasiporo kandi irashobora kugenzurwa kuri iki cyiciro kugirango ihindure imitungo yibicuruzwa byanyuma bya HPMC.

Alkali: Gutesha agaciro no kugenzura vicosity

Nyuma yo gutora no kwerekana methylation inkingi, HPMC yavuyemo ni alkaline. Ishingiro nka sodium hydroxide ikoreshwa mugukuramo ibicuruzwa. Iyi ntambwe ningirakamaro kugirango igere ku rwego rwifuzwa kandi izamura umutekano wa HPMC. Ongeraho ishingiro nanone bifasha kugenzura viscosiya ibisubizo bya HPMC, bigatuma bakwiranye nibisobanuro bitandukanye aho urusengero rufite uruhare runini, nkibikoresho byumutungo hamwe nibikoresho byubwubatsi.

Kwezwa no kugisimba: kubuza ubuziranenge

Nyuma yo guhindura imiti, ibicuruzwa bya HPMC byegerejwe kugirango ukureho ibikoresho bibisi bibisi, ibicuruzwa, cyangwa umwanda. Iri suku rimaze kugerwaho ukoresheje inzira yo kunyuramo, kureba niba ibicuruzwa byanyuma byahuje HPMC byujuje ubuziranenge bukenewe. Gusukura nintambwe ikomeye yo gukuraho ibintu bidakenewe bishobora kugira ingaruka kumikorere n'umutekano wa HPMC muburyo bwateganijwe.

Gusaba HydroxyPropyl methylcellse

Farumasi cical: HPMC ikoreshwa cyane mu nganda za farumasi nka binder, film yahoze igenzurwa n'umukozi urekura muri Tablet. Ubushobozi bwayo bwo gukora firime zitwara ibintu bituma bikwiranye no guhinga tablet, bitanga urwego rukingira kandi rugenzura ibiyobyabwenge.

Kubaka: Mu nganda zubakwa, HPMC ikoreshwa mu bikoresho bishingiye ku byaro nka minisiteri, stucco, no gukomera. Ikora nkumubyimba, amazi agumana umukozi, kandi atezimbere imikorere no kumeza.

Inganda zibiribwa: HPMC ikoreshwa munganda zibiribwa nkabahurira, stabilizer na emalisiier. Ikoreshwa mubicuruzwa bitandukanye byibiribwa, harimo isosi, imyambarire n'ibiribwa.

Kwisiga: Muri kwisiga, HPMC ikoreshwa muri formulane nka cream, amavuta, na shampoos kugirango itange imiterere, guteza imbere umutekano, no kuzamura imikorere rusange yibicuruzwa.

Irangi n'amakota: HPMC ikoreshwa nkuwabyimbye kandi ikingamiro mumikino ishingiye ku mazi hamwe no gufatanya kugirango afashe kunoza imvugo.

Ibicuruzwa byita kugiti cyawe: HPMC iboneka muburyo butandukanye bwita ku giti cye, harimo no kwizirika no kwita ku musatsi, aho bikora nk'urugendo runini na vicoire.

HydroxyPropyl methylcellse ni polymer ifite agaciro ifite porogaramu nini mu nganda zitandukanye. Synthesis ya HPMC ikubiyemo gukoresha selile, ibyatsi bya proppide, methyl chloride, alkali hamwe nintambwe zo kweza kugirango ibicuruzwa byiza. Guhinduranya bya HPMC kuva mubushobozi bwayo bwo guhindura imiti yumubiri na shimi ya selile, bikayigira ibintu byingenzi muri farumasi, ibikoresho byubaka, ibiryo, kwisiga, ibisigazwa nibicuruzwa byitaweho. Gusobanukirwa ibikoresho fatizo hamwe nuburyo bwa synthesis nibyingenzi kugirango bidoze HPMC kubisabwa byihariye no guhitamo imikorere yayo muburyo butandukanye.