Nibihe bintu bya shimi bya hpmc hypromellose?

Hypromellose, uzwi kandi nka hydroxyPropyl methylcellse (HPMC), ni polymer ya sinteti ikomoka kuri selile. Byakoreshejwe cyane muri farumasi, ibiryo nibirori byumuyaga nkububi, Emalifier na binder. HPMC ni ibintu bitari uburozi kandi biliodedadable, bigahitamo neza kandi byinshuti.

1. Kukecuruza amazi

HPMC irashonje mumazi kandi ikora igisubizo gisobanutse cyangwa gito gito. Kudakemurwa na HPMC biterwa nicyiciro cyayo cyatsinzwe, uburemere bwa molecular nurwego rwo gusimbuza. Isubukuru yo hejuru hamwe namanota yuburemere bwa molekile ntabwo akundwa kuruta amanota yo hasi. Urwego rwo gusimburwa rugena umubare wa hydroxy osippepyle na methyl ifatanye na hpmc selile ishize. Urwego rwo hejuru rwo gusimbuza, hepfo amazi yoroheje.

2. Imiti igenda

HPMC irimo imiti kandi ntiyitwara hamwe n'imiti kama ngengabuzima. Irwanya alkalis, abacura badafite intege nke hamwe nibibi byinshi. Ariko, HPMC yitwara hamwe nicide ikomeye hamwe nibikoresho bya okiside, biganisha ku gutesha agaciro no gutakaza imikorere. Kubwibyo, birasabwa kwirinda kwerekana HPMC kumacugi ikomeye cyangwa abakozi ba okiside.

3. Imiterere ya firime

HPMC ifite imitungo myiza ya firime kandi ibereye igikomambo cya tablet, ikomeza kurekura no gukomera. Filime yakozwe na HPMC irahinduka, mu mucyo kandi yoroshye. Filime nayo irinda gutesha agaciro ibintu bikora muri tablet cyangwa capsule.

4. Gelation

Ukurikije urwego rwarwo, HPMC ihura na pelation yubushyuhe mugihe ashyushye mumazi hejuru yubushyuhe runaka. Ubushyuhe bwa Pelalan buva kuri 50 ° C kugeza 90 ° C. Gel yashizweho na HPMC irahinduka, bivuze ko ishobora gushonga mu buryo bwamazi akonje. Uyu mutungo utuma HPMC ibereye ko HPMC ikwiye gukoreshwa mugenzurwa-igenzurwa, kubera ko ibiyobyabwenge bishobora kurekurwa ku bushyuhe runaka.

5. Ibintu bya mothelogiya

HPMC yerekana imyitwarire ya pseudoplastique, bivuze ko ubukuru bwayo bugabanuka hamwe no kongera imigenzo. Uyu mutungo ukora HPMC ibereye gukoreshwa nkuwabyimbye kandi uhagaze mubiryo no kwisiga. HPMC ikoreshwa kandi nkumukozi wahagaritswe kubera imyitwarire yayo ya Thixotropic, bivuze ko vico yayo iragabanuka zikomeje guhangayika.

HPMC ni ibintu bisobanutse kandi bifite umutekano hamwe nimiti myiza ya chimique. Amazi yoroheje, gushikama imiti, imitungo yo gushinga filime, umutungo wa TheRogell na Rheologiya ugira amahitamo azwi mu nganda zitandukanye. HPMC nayo ikomokaho no kuba inshuti ibidukikije, ikabigira amahitamo arambye.