Gucira urubanza ubuziranenge bwa hydroxyproppopyl methyl selile

HydroxyPropyl Methyl Cellulose (HPMC) ni polymer itandukanye isanga mu nganda zinyuranye, harimo imiti, kubaka, ibiryo, kwisiga, nibindi byinshi. Gusaba kwayo bitandukanye biva mumitungo yihariye, nko mubushobozi bwa firime, ubushobozi bwo kwishyuza, imitungo ihuza, hamwe nibiranga amazi. Ubwiza bwa HPMC ni ngombwa kugirango tubone imikorere n'umutekano wibicuruzwa bikoreshwa.

1.Ibigize ibigize:
Ibigize imiti bya HPMC nibyingenzi kurwego rwayo. HPMC ni ukomoka kuri selile, byahinduwe binyuze muri hydroxy oplelation no gutunganya imitsi. Urwego rwo gusimbuza (DS) rwa HydroxyPropyl na Methoxy trafroppopyl na Methoxy bigira ingaruka ku buryo bugira ingaruka ku mitungo yayo. Indangagaciro za DS muri rusange ziterwa no kongera amazi yo kwiyongera no kugabanuka ubushyuhe bwa gelateri. Ubuhanga bwo gusesengura nka kirimbuzi ya rukuruzi (NMR) neza kandi infrared (IR) bikunze gukoreshwa kugirango hamenyekane imiti na DS yicyitegererezo cya HPMC.

2.Kurikira:
Ubuziranenge ni ikintu gikomeye cya HPMC ireme rya HPMC. Umwanda urashobora kugira ingaruka kumikorere no gutuza kubicuruzwa. Impitabiri zisanzwe zirimo ibisigisigi bisigaye, ibyuma biremereye, na Microbial yanduye. Uburyo butandukanye bwo gusesengura nkamaso-yisumbuye ya chromatografiya (HCPC), na gaze ya chromatography (gc), hamwe na plasma-misa ya plasma-misa (ICP) yakoreshejwe kugirango isuzume ubuziranenge bwa HPMC.

Uburemere 3.BYabitswe:
Uburemere bwa moleki ya HPMC bugira ingaruka kumiterere ya motelelogiya, kudusaba, no gukora firime. Uburemere bwo hejuru bwa moleclar HPMC mubisanzwe bigaragaza viscosity nini nimbaraga za firime. Gel Urutonde rwa Chromatography (GPC) nubuhanga bukoreshwa cyane bwo kugena ibipimo byimbuto bya moleclar byinteruro ya HPMC.

4.Viscossity:
Ibyatsi ni ikintu cyingenzi kuri HPMC ireme rya HPMC, cyane cyane mubisabwa nkibikoresho byimiti, aho bikora nkumukozi wijimye. Ibyamamare bya HPMC Ibisubizo bya HPMC bigira ingaruka kubintu nkibitekerezo, ubushyuhe, hamwe nigipimo cyamasaruro. Uburyo butandukanye bwa Visicottric, harimo na Rosetional Vicometry na Capillary viughttry, bakoreshwa mugupima vicosity ibisubizo bya HPMC kubihe bitandukanye.

5.ph no kwishuka:
PH hamwe nibirimo bya HPMC birashobora kugira ingaruka kumutekano no guhuza nibindi bikoresho. Ibirimo byingenzi cyane cyane nkuko ubuhehere bukabije bushobora kuganisha ku mikurire ya microbial no gutesha agaciro HPMC. Imyenda ya Karl isanzwe ikoreshwa mu kumenya ibintu byubushuhe, mugihe PH Metero akoreshwa mugupima PH.

6.Ibikoresho by'ikariso na morphologiya:
Ingano yashizwemo na morfologiya ifite uruhare rukomeye mumiterere yurugendo no kudahatanya poweri ya HPMC. Tekinike nka Laser Disfraction no gusikana microscople (sem) yakoreshejwe kugirango iranga ingano yo gukwirakwiza ibice na morphologiya ya HPMC.

Mathermalties:
Ubushyuhe bwumuhanda nkubushyuhe bwinzibacyuho (TG) nubushyuhe bwo gutesha agaciro ubushyuhe butanga ubushishozi mubikorwa byumutekano no gutunganya HPMC. Ububiko butandukanye bwo gusikana (DSC) na TheRogravimetric yasesengura (TGA) bikunze gukoreshwa mugusesengura imyitwarire yubushyuhe bwa HPMC.

8.Gukora no gushiraho firime:
Kubisaba bisaba Gel Gushiraho Gel cyangwa firime, ubushyuhe bwa gelala na firime bya film bya HPMC nibipimo byingenzi. Ibipimo bya Rheologiya hamwe nibizamini bya firime bikozwe kugirango usuzume iyi mitungo mubihe bifatika.

Gusuzuma ubwiza bwa hydroxyproppopyl methyl Methyl Methil Ubuhanga butandukanye bwo gusesengura bukoreshwa kugirango dusuzume ibipimo, tubona ko HPMC yujuje ibisobanuro bisabwa kubisabwa. Mugukomeza ubuziranenge buhebuje, abakora HPMC barashobora kwemeza imikorere, umutekano, n'imikorere y'ibicuruzwa hirya no mu nganda zinyuranye.