Intro ya Bastic ya Hec na HPMC

IRIBURIRO RYA HEC (HydroxyAythyl Cellulose) na HPMC (HYDROXYPropyl methylcellse)
HydroxyAythyl Cellulose (HEC) na hydroxyPropyl methylcellse (HPMC) ni ibigo bibiri by'ingenzi bya churigisi byateguwe mu nganda zinyuranye, harimo imiti, kubaka, kwita ku byifuzo byawe bwite, n'ibiryo. HPMC na HPMC bombi bakomoka kuri selile, Polymer nyinshi nini cyane iboneka mu rukuta rwa Cendation, zizwiho imbaraga zayo no kunyuranya.

Hydroxyyeryl selile (hec)
Imiterere yimiti hamwe numutungo
Hydroxyyeryl selile ni ut-polymer yoroheje, yo gukosora amazi yaturutse kuri selile binyuze muburyo bwo guhindura. Imiterere yayo ya fotoimique ikubiyemo amatsinda ya etyyne (ch2ch2oh) yometse kuri selile inyuma, yongera amazi yayo no kubyimba. HEC igaragara nkumweru kuri ifu yera kandi izwiho viscosity yacyo nubushobozi buhebuje bwa firime.

Inzira ya Synthesis
Synthesis ya Hec irimo reaction ya selile hamwe na ethylene okide ya alkaline. Inzira isanzwe irimo:

Alkalisation: Cellulose yafatwa na alkali ikomeye, nka sodium hydroxide, kugirango ikore selile ya alkali.
Guhangana: Etylene oxide noneho yongerwaho kuri selile ya alkali, bikaviramo gushiraho hydroxyyethyl selile.
Kutabogama no kwezwa: Kuvanga reaction biratabogamye kandi bisukurwa kugirango bikureho ibicuruzwa, bitanga ibicuruzwa byanyuma.

Porogaramu
HEC ikoreshwa mu nganda zitandukanye kubera imitungo idasanzwe:

Farumasi: ikoreshwa nkumukozi wijimye, firime-wahozeho, na stabilizer muri gels yibanze, amavuta, namavuta.
Kwitaho kugiti cyawe: iboneka muri shampoos, gakondo, amavuta, hamwe na mane nkumubyimba na emalifiire.
Irangi n'amakoti: Kuzamura vicosi, kugumana amazi, hamwe n'imitungo yo gukora film mu gishushanyo gishingiye ku mazi.
Kubaka: ikora nk'ibunderi, umubyimba, hamwe n'ahantu ho kugumana amazi muri sima n'ibicuruzwa bishingiye ku banyarwanda.
Ibyiza

Hec itanga ibyiza byinshi:

Kamere itari Aonic: Bituma bihuza nurugero runini rwa Ionic na Aionic.
Kurengera amazi: byoroshye gusesa mumazi akonje namazi, bikora ibisubizo bisobanutse.
Guhuza imikorere: bitanga urujijo rwinshi muburyo butandukanye.
BiocompaTutions: Umutekano wo gukoresha mu bicuruzwa bitwara imiti no kwita ku kugiti cyawe.

HydroxyPropyl Methylcellse (HPMC)
Imiterere yimiti hamwe numutungo
Hydroxypropyl Methylcellulose is another non-ionic cellulose ether, characterized by the substitution of hydroxyl groups in the cellulose molecule with methoxy (-OCH3) and hydroxypropyl (-CH2CHOHCH3) groups. Iyi miterere itanga ibipimo bidasanzwe byumuriro kandi bituma HPMC ishonje haba mu mazi akonje n'amazi ashyushye. HPMC iraboneka kandi nkumuzungu kuri ifu yera.

Inzira ya Synthesis
Umusaruro wa HPMC urimo inzira nkiyi:

Alkalisation: Cellulose ifatwa na alkali ikomeye kugirango ikore selile ya alkali.
Guhangana: Guhuza methyl chloride na propaylene oxide yongewe kuri selile ya alkali, biganisha kumushinga wa hydroxyPropyl methylcellse.
Kutabogama no kwezwa: Uruvange rurimo kutabogama, kandi hashyizweho intambwe zikorwa kugirango ubone ibicuruzwa byanyuma bya HPMC.

Porogaramu
Ibisobanuro bya HPMC bituma rikoreshwa mumirima itandukanye:

Ibikoresho bya faruzi: Ibyakozwe nkabakozi bagenzuwe, binder, hamwe nibikoresho byo gusiga film muri tablet.
Inganda zibiribwa: zikora nk'igituba, stabilizer, na emalifie mu biribwa byatunganijwe.
Kubaka: Byakoreshejwe nk'uburebure, ushinzwe kugumana amazi, no gufatira mu mico ya sima ishingiye ku bacuramye.
Kwitaho kugiti cyawe: Biboneka muri Westhispite, shampoos, no kwisiga kumanuka no gukabije.

Ibyiza
HPMC itoneshwa kubwimpamvu nyinshi:

Ubushyuhe bwa Dolanal: Erekana ahantu hashyushye, bifitiye akamaro muri porogaramu zimwe na zimwe.
Kukemeranya: gushonga mumazi akonje n'amazi ashyushye, yemerera gukoresha gukoresha ibintu bitandukanye.
Ubushobozi bwo gushinga film: Gushiraho firime zikomeye, byoroshye, byiza byo guhuriza hamwe no kugenzurwa-kurekura.
Uburozi: Umutekano wo gukoresha mubiryo nibikoresho bya farumasi, hamwe na bioconatible nziza.

Kugereranya Hec na HPMC
Ibisa
Inkomoko: Byombi biva muri selile kandi basangire inzira zisa zirimo guhinduka.
Imitungo: HPMC yombi na HPMC ntabwo ari ionic, gushonga amazi hamwe nibibyimba byiza, gushiraho film, hamwe no guhungabanya umutungo.
Porogaramu: Zikoreshwa mu nganda zitandukanye, zirimo imiti, kwita ku muntu ku giti cyabo, no kubaka.
Itandukaniro
Abasimbuye imiti: Hec irimo amatsinda ya hydroxyyeryth, mugihe HPMC ifite uburyo na hydroxyPropyle.
Ubushyuhe: HPMC yerekana ifaranga ryubushyuhe, bitandukanye na Hec, bigatuma habaho ibyifuzo byihariye aho haterwa haterwa ubushyuhe ari ingirakamaro.
Kukemeranya: Mugihe byombi ari ugukemura amazi, kuba hari amatsinda ya hydroxyPropyl muri HPMC yongerera ibintu byayo byoroheje muri kama ugereranije na Hec.

Hydroxyyeryl selile (hec) na hydroxypropyl methylcellse (HPMC) ni ngombwa muri selile ikoreshwa mu nganda zidasanzwe kubera imitungo yabo idasanzwe. HEC ifite agaciro cyane kubasura cyane no guhuza inyongeramuzi zitandukanye, mugihe HPMC itandukanye numutima wa pelation ya gelation hamwe nubukungu bugari. Gusobanukirwa imiterere, synthesis, hamwe nibisabwa byibi polymers bifasha muguhitamo ibikomoka kuri selile ikeneye inganda, bityo bikamura imikorere nubwiza bwibicuruzwa byanyuma.