Mubigishe inzira nyinshi zo kugenzura ireme rya hydroxyproppopyl methylcellse

HydroxyPropyl MethylcellAlose (HPMC) ni ugukemura amazi ya polymer bikoreshwa muri farumasi, ibiryo, ibikoresho byo kubaka nibindi bikoresho. Ubwiza bwimiterere yacyo bugira ingaruka kumurimo no gutuza ibicuruzwa.

1. Kugaragara n'ibara
Kugaragara nibara nibyo byabanjirije gusuzuma ubuziranenge bwa hydroxyproppeproppopyl methylcellse. Ubwiza bwiza Hpmc nubunini bwera cyangwa butari bwera hamwe nuburyo bumwe kandi bworoshye. Ibara ntirigomba kuba umuhondo, ibara ry'umukara cyangwa iyo ari yo yose idasanzwe, ishobora kuba yatewe no kwangirika biterwa n'ibikoresho bitesha agaciro cyangwa kubika bidakwiye mugihe cyo kubyara. Niba ibara ridasanzwe, rishobora kwerekana ko hari ikibazo cyicyiciro cyibicuruzwa no kugenzura ibindi bisabwa.

2. Ifu ya Powder
Ikwirakwizwa ryinshi ni kimwe mubintu byingenzi mugusuzuma ubwiza bwa HPMC. HPMC yubuziranenge neza busanzwe ifite ubunini bumwe. Inini cyane cyangwa uduce duto cyane bizagira ingaruka kukeshawe no gukurikizwa muburyo bufatika. Ingano yinshi irashobora gusesengurwa no gusebanya cyangwa gusesengura igice cyisuku. Ibice binini cyane birashobora gutuma umuntu acukurwa kandi agira ingaruka kuri viscosity kandi imwe. Inzira zitandukanye zo gusya zirashobora gukoreshwa mugutanga ikwirakwizwa ryibice kugirango HPMM ishobore gukora neza muburyo bugenewe.

3.. UBUGINGO BW'AMAZI N'UMUNTU
Amazi yoroshye ya HPMC nicyo kimenyetso cyingenzi cyo gusuzuma ubuziranenge. Kudakemurwa kwayo mubisanzwe bigira ingaruka kumiterere ya molecular hamwe nurwego rwo gusimbuza hydroxyPropyl na methyl. Ubwiza-bwiza HPMC irashobora gushonga vuba mumazi kugirango ikore igisubizo giboneye kandi kimwe. Kugira ngo ugerageze mu mazi, umubare runaka wa HPMC urashobora kongerwaho amazi, ukangurwa ku bushyuhe runaka, hamwe n'umuvuduko wacyo n'imyanda isenyuka nyuma y'iseswa rishobora kubahirizwa. Niba bishonga buhoro cyangwa bitera ibibyimba bidahunnye, birashoboka ko umuco wa HPMC utujuje ibyangombwa.

4. Ikizamini cya STCcosity
Ibyatsi bya HPMC nicyo kimenyetso cyingenzi kigaragaza ubuziranenge bwayo, cyane cyane iyo gikoreshwa nkumubyimba, emalifier cyangwa umukozi wa gelling. Ubusanzwe viscosity ifitanye isano nuburemere bwa molekile nurwego rwo gusimbuza HPMC. Ubukwe bwayo burashobora kugeragezwa na vicometer izunguruka cyangwa rhemeter kugirango basuzume ibintu byayo. Byaba byiza, viscosity ya HPMC igomba guhagarara murwego runaka kugirango barebe imikorere yayo muburyo butandukanye.

Iyo HPMC igerageza viscosity, HPMC igomba gushonga mubintu bimwe na bimwe byamazi, ubushyuhe bugomba guhinduka, hamwe nibiranga ibitekerezo byigisubizo cyikibazo gitandukanye kigomba gupimwa. Niba uruzitiro rudasanzwe, rushobora kugira ingaruka kumikorere ya HPMC, cyane cyane mugusaba hamwe nibisabwa kwisumbuye.

5. Kugena urwego rwo gusimbuza
Urwego rwo gusimbuza (DS) bivuga igipimo cya hydroxyPropyl na methyl matsinda ya methy muri molekile ya HPMC. Urwego rwo gusimbuza rugira ingaruka ku buryo butaziguye, vicosity hamwe nindi miti yumubiri na shimi. Ubuhanga nko kugereranya (FTER) cyangwa NUCLEAR) bisanzwe (NMR) mubisanzwe bikoreshwa mugusesengura ibikubiye muri methyl na hydroxyPropyl amatsinda muri molekile ya HPMC.

Kubwiza buhebuje HPMC, urwego rwo gusimbuza rugomba kuba murwego rwagenwe. Hejuru cyane cyangwa hasi cyane gusimburwa birashobora kuganisha kumikorere idahungabana kandi bigira ingaruka kumiterere yibicuruzwa byanyuma. Kurugero, hejuru cyane gusimburwa methyl birashobora kugira ingaruka kumazi yacyo, mugihe gito gusimburwa no guhindura imikorere yacyo.

6. Kugena ibikubiyemo
Ibirimo byubushuhe nimwe mubintu byingenzi bireba ubwiza bwa HPMC. Ibirimo byinshi cyane birashobora gutera ibicuruzwa na disiki no gutera imbere, bityo bigira ingaruka kumikorere yayo. Ibirimo ubushuhe muri rusange bigenwa no kumisha cyangwa karl fischer tischer. Ibirimo byimazeyo kuri HPMC yo hejuru HPMC igomba kuba munsi ya 5% kugirango irekurwe ko ireme ridahinduka mugihe cyo kubika no gukoresha.

7. Ikizamini cya PH
PH agaciro ka HPMC igisubizo nacyo nikimenyetso cyingenzi cyubwiza bwayo. Igisubizo cya HPMC kigomba kugira agaciro gahamye PH, muri rusange hagati ya 4.0 na 8.0. Ibisubizo bikabije cyangwa alkaline birashobora kugira ingaruka kumihane yacyo no mubikorwa mubisabwa. Agaciro PH karashobora kugenwa no gupima PH yumuti ukoresheje phi Meter.

8. Kwipimisha Microbiologiologiologio
HPMC ni urwitwazo rusanzwe rukoreshwa mubikorwa byimiti nibiribwa, kandi kwanduza microbial ya microbial bikenera kwitabwaho bidasanzwe. Kwanduza microbial ntabwo bigira ingaruka kumutekano wibicuruzwa, ariko birashobora kandi gutera ibicuruzwa kwangirika cyangwa kwangirika mubikorwa. Kwipimisha microbial birashobora gukorwa numuco, PCR nubundi buryo kugirango tumenye ko isuku ya HPMC yujuje ibisabwa n'amabwiriza ashinzwe.

9. Isesengura rya Thermogravimetric (Tga) na Calorimetry itandukanijwe (DSC)
Isesengura rya Thermogravimetric (tga) hamwe nububiko butandukanye bwo gusikana (DSC) burashobora gukoreshwa mukwiga ubushyuhe bwa HPMC hamwe nibiranga ibyabo mugihe cyo gushyushya. Ubu buryo bushobora kubona amakuru yingenzi nkigihombo rusange, gusangira, hamwe nubushyuhe bwinzibacyuho bwa HPMC kubushyuhe butandukanye kugirango bufashe kumenya niba ihuye nibisabwa.

10. Kugena ibirimo chloride
Niba HPMC ikubiyemo chloride nyinshi, bizagira ingaruka kumuntu wo kwikeba no gushikama mubisaba. Ibirimo byayo birashobora kugenwa na flame photometry cyangwa imigambi ya potentiometric. Ibirimo bya HPRC hamwe nubwiza bwiza bigomba kugenzurwa murwego runaka kugirango umutekano we wizeza umutekano.

Uburyo bwavuzwe haruguru burashobora gusobanukirwa ubwiza bwa hydroxyproppopyl methylcellrose, harimo isura, victolity, vinosiyality, urwego rwo gusimbuza, ibikubiyemo. Gusaba bitandukanye bifite ibisabwa bitandukanye kuri HPMC, mugihe rero gusuzuma ubuziranenge bwayo, ni ngombwa gukora ibizamini byuzuye hamwe nibikenewe byimirima yihariye. Ubu buryo bwo gupima burashobora kwemeza umutekano, imikorere n'umutekano wibicuruzwa bya HPMC, bitanga ingwate kubisabwa byose.