Kwiga ku mibanire iri hagati ya vickomc nubushyuhe

HPMC (HydroxyPropyl Methylcellsellse) ni ikigo cya Polymer gikunze gukoreshwa, gukoreshwa cyane mubuvuzi, ibiryo, kwisiga, kwisiga, kwisiga, kubaka no guharanira inganda. Imikorere yayo igira ingaruka kubintu byinshi, muri nubushyuhe bufite ingaruka zikomeye kuri viscosity yo gukemura HPMC.

1. Ibiranga ishingiro rya HPMC
HPMC ni compound ya polymer yabonetse kubijyanye no guhindura imiti ya selile selile. Ifite amazi meza yoroheje, imitungo yo gukora firime, kubyimba no gutuza. Kuberako imiterere ya shimi irimo amatsinda ya hydrophilic nka hydroxyl na methyl matsinda ya methyl, hpmc irashobora gukora igisubizo kinini cya stacositity mumazi. Urubanza rwayo rufitanye isano rya bugufi nibintu nkibitekerezo, uburemere bwa molecular, ubushyuhe, na ph agaciro k'igisubizo.

2. Ingaruka z'ubushyuhe kuri viscosity yo gukemura HPMC
Kwiyongera mubushyuhe biganisha ku kugabanuka kwa vino
Ibyatsi byo gukemura HPMC bigabanya ubushyuhe, busa nimitungo yibisubizo byinshi bya polymer. Iyo ubushyuhe buzamutse, icyerekezo cyubushyuhe bwamazi mugisubizo cyiyongera, imbaraga zimikoranire hagati ya molekile (nka hydrogen inoti zo mu gahoro, kandi guhuza uruniko rwa HPMC gahoro gahoro, bikaviramo kugabanuka kwa vino. By'umwihariko, kwiyongera k'ubushyuhe byangiza buhoro buhoro umuyoboro wa Corse-Hydrogen hagati y'iminyururu ya HPMC, bituma iminyururu ikundana hpmc yimuka cyane, bikaviramo iminyururu ya HPMC kwimuka cyane, bikaviramo ibintu byiyongereye kandi bigabanuka.

Ingaruka z'ubushyuhe kuri molekile
Uruzinduko rw'igisubizo cya HPMC ntabwo gifitanye isano nuburemere bwa molekingo gusa no kwibandaho, ariko nanone bifitanye isano rya bugufi no kugenda k'umunyururu wa molekile. Ubwiyongere bwubushyuhe bwongerera ubushyuhe bwa molekile y'amazi mugisubizo, kandi ibikorwa byimpanuka za HPMC nabyo biriyongera. Mugihe ubushyuhe bwiyongera, guhinduka kwiminyururu ya HPMC byiyongera, kandi amahirwe yo kugabanuka cyangwa kwaguka kwiyongera, bihindura imiterere yumuti, kugaragara nkigabanuka ryinshi.

Isesengura ryimihindagurikire y'ibyiringiro
Umubano hagati ya virusire nubushyuhe bwibisubizo bya HPMC birashobora gusobanurwa nikigereranyo cya Arrhenius. Ikigereranyo cyerekana ko hari umubano runaka ugaragara hagati ya viscolity yumuti nubushyuhe. By'umwihariko, viscosity (η) y'igisubizo irashobora kugaragazwa nka:
η = η0 exp (TEA)
Muri bo, η_0 ni uhoraho, e_a ni imbaraga zo gukora, r ni gaze ihoraho, kandi t ni ubushyuhe. Ku bushyuhe bwo hejuru, ingufu zikora zifite ingaruka zikomeye, bigatera victoity yumuti wo guta cyane hamwe nubushyuhe bwiyongera.

Umutekano wa Lurmal wo gukemura HPMC
Nubwo viscolity ya HPMC igabanuka hamwe nubushyuhe bwiyongera, igisubizo cya HPMC gifite umutekano mwiza mubushyuhe runaka. Ku bushyuhe bwa ultra-burebure, iminyururu ya HPMC irashobora gutesha agaciro, bikaviramo kugabanuka muburemere bwayo bwa moleki, nayo itera igitonyanga gityaye. Kubwibyo, mubikorwa bifatika, ibisubizo bya HPMC bigomba kwirindwa gukurwa mubushyuhe burenze ubushyuhe burenze urugero rwabo ruhamye.

3. Ingaruka zifatika zubushyuhe kuri viscosity ya HPMC Ibisubizo bya HPMC
Inganda za farumasi
Mu nganda za farumasi, HPMC ikunze gukoreshwa nkuwagejejweho hakurikijwe ibiyobyabwenge, ibikoresho byo gupimisha capsule, hamwe nuwashimwe mubindi byitegura bikomeye. Ingaruka zubushyuhe kuri viscosity yayo ifitanye isano itaziguye nuburyo bwiza bwo kwitegura. Ikirenga cyane kizavamo bike cyane kuri stosity, bigira ingaruka kubipimo byo kurekura no kurwanya ingaruka zibiyobyabwenge, birakenewe rero gukora mubushyuhe bukwiye.

Inganda
Mu nganda zibiribwa, HPMC ikoreshwa cyane nkumunyefiri na emalifiire. Mugihe cyo gutunganya ibiryo, ihindagurika ryubushyuhe rishobora kugira ingaruka kumiti ya HPMC, bityo bigira ingaruka kuryohe nuburyohe bwibicuruzwa. Kubwibyo, kumenya ibimenyetso byerekana igisubizo cya HPMC ku bushyuhe butandukanye bizafasha kugenzura neza inzira yo gutunganya ibiryo no kwemeza umutekano nuburyohe bwibicuruzwa byanyuma.

Ubwubatsi no gupakira inganda
Mu rwego rwo kubaka no kurera, uruhare nyamukuru rwa HPMC ni nk'igituba n'amazi. Mugihe ubushyuhe buhinduka, ihinduka rya HPMSIty rya HPMC rizagira ingaruka kumasura, gusohora no gukora imirimo yubwubatsi bya beto cyangwa amatara. Kubwibyo, mubikorwa bifatika, birakenewe guhindura ingano ya HPMC ukurikije ubushyuhe bwibidukikije kugirango habeho iterambere ryiyobe.

Inganda zo kwisiga
Muri kwisiga, HPMC ikunze gukoreshwa mu gushyiraho ibicuruzwa nka gels na elulisions. Ingaruka z'ubushyuhe kuri viscolity ya HPMC irashobora kugira ingaruka ku gukwirakwiza, gushikama no kugaragara imiterere y'ibicuruzwa. Ku bushyuhe butandukanye, viscosity ihinduka yo kwisiga irashobora kugira ingaruka kumyumvire yumuguzi, niko ubuyobozi bwuzuye bwo gucunga ubushyuhe busabwa mugihe cyo kubyara.

Ingaruka z'ubushyuhe kuri viscosity yo gukemura HPMC nigikoresho kigoye cyumubiri nubushyuhe kirimo ibintu nkibihinduka bihuye nibikorwa bya molekile hamwe nimpinduka mumbaraga zimikoranire. Muri rusange, ubwiyongere bwubushyuhe buzatera kugabanuka muri viscolity yo gukemura HPMC, ariko muburyo bufatika, ibintu byinshi bigomba gusuzumwa, nkubushyuhe, hamwe nuburemere bwa HPMC ya HPMC. Mu kwiga byimazeyo isano iri hagati ya viscosity nubushyuhe bwigisubizo cya HPMC, turashobora gutanga ishingiro ryubumenyi bwo gushyira mubikorwa inganda zitandukanye, tunoza imikorere yumusaruro, no kunoza ubuziranenge bwibicuruzwa.