Guhagarara bya HydroxyAythyl Cellulose mubidukikije bitandukanye

HydroxyAythyl Cellulose (HEC) ni polymer ikoreshwa cyane mu nganda zitandukanye kubera imitungo yihariye nko kwishyurwa n'amazi, n'ubushobozi bukabije. Gusobanukirwa gushikama muburyo butandukanye bwa PH ni ngombwa kugirango usabe neza.

HydroxyAythyl Cellulose (HEC) ni ukomoka kuri selile, uko bisanzwe biboneka mu rukuta rw'ibimera. HEC yakwitayeho cyane munganda nka faruceti, kwisiga, ibiryo, no kubaka kubera ubushobozi bwayo budasanzwe, harimo no kwishyurwa n'amazi, ubushobozi bwa filime, na biocompat. Ariko, gushikama kwa HEC mubihe bitandukanye bya PH ni ngombwa kugirango usabe neza muburyo butandukanye.

Umutekano wa HEC urashobora guterwa nibintu byinshi, hamwe na PH kuba kimwe mubipimo bikomeye cyane. PH igira ingaruka kuri ionisation imiterere yimikorere yimikorere ihari muri hec, bityo bikaba bitanga umusaruro, vicosiya, nibindi bintu. Gusobanukirwa imyitwarire ya HEC mubidukikije bitandukanye ningirakamaro kubashinzwe guhitamo imikorere yayo muburyo butandukanye.

1.Imiterere ya hydroxyyeryl selile.
HEC yanyuze mu myitwarire ya selile hamwe na etylene okiside, bikaviramo gutangiza amatsinda ya hydroxyyerythy kuri selile. Urwego rwo gusimbuza (DS) rwitsinda rya hydroxyerthyl rigena imitungo ya HEC, harimo no kwikebagura no kwinuba. Imiterere yimiti ya Hec itanga ibiranga bidasanzwe bituma bikwiranye nibisabwa bitandukanye byinganda.

Amatsinda yibanze muri hec ni hydroxyl (-Oh) na ether (-o-) amatsinda, akagira uruhare runini mumikoranire n'amazi nandi molekile. Kubaho kwa Hydroxyyerll Kuzuza Hydrophiley yongera hydrophilose ya selile, biganisha ku mazi yoroheje ugereranije na selile kavukire. Ihuza rya Ether ritanga umutekano kuri Molekile ya Hec, kubuza kwangirika mubihe bisanzwe.

2.Ibintu na PH:
Guhagarara kuri HEC mubidukikije bitandukanye byatewe no ionisation yimikorere yayo. Muri aside (ph 7), amatsinda ya hydroxyl muri HEC irashobora kugikora protonation, bituma bigabanuka kwikebanuwe no gusya. Ibinyuranye, muburyo bwa alkaline (ph> 7), gucikamo amatsinda ya hydroxyl birashobora kubaho, bigira ingaruka kumitungo ya polymer.

Kuri ph yo hasi, protonasiyo yamatsinda ya hydroxyl irashobora guhungabanya imikoranire ya hydrogen muri Matrix Polymer, biganisha kugabanya intege nke no kubyimba. Iyi ngingo ivugwa cyane kurwego rwo hejuru rwo gusimburwa, aho umubare munini wamatsinda ya hydroxyl aboneka kugirango ange. Nkigisubizo, viscozetity yibisubizo bya hec irashobora kugabanuka cyane mubidukikije bya acide, bigira ingaruka kumikorere yayo nkumukozi wijimye.

Ku rundi ruhande, mu bihe bya alkaline, gucikamo amatsinda ya hydroxyl birashobora kongera igisubizo cya HEC kubera imiterere ya ions alkoxide. Nyamara, alkalinity yarenze irashobora kuganisha ku gutesha agaciro polymer binyuze muri base-catalined hydrolysis ya ether ihuza, bikaviramo kugabanuka kwa victositike nibindi bintu. Kubwibyo, kubungabunga PH muburyo bukwiye ni ngombwa kugirango umutekano wa Hec mubintu bya alkaline.

3. Ingaruka zifatika:
Guhagarara kuri Hec mubidukikije bitandukanye bifite ingaruka zikomeye gukoreshwa munganda zitandukanye. Mu nganda za farumasi, hec ikunze gukoreshwa nkumukozi wijimye mubikorwa byo mu kanwa nkibihagarikwa, Amajugunya, na gels. PHI y'aya mafranga agomba kugenzurwa neza kugirango akomeze virusi yifuzwa kandi ituze ya HEC.

Mu buryo nk'ubwo, mu nganda zihirika, HEC ikoreshwa mubicuruzwa nka shampos, amavuta, amavuta, no kwisiga kumanuka kandi atera imitungo. PHI y'aya mashusho arashobora gutandukana cyane bitewe nibisabwa byihariye nibisabwa na hec hamwe nibindi bikoresho. Abashinzwe gushimugisha bagomba gutekereza ku ngaruka ya PH mu gihagararo no gukora ECC kureba ibicuruzwa no kunyurwa n'umuguzi.

Mu nganda zibiribwa, Hec ikoreshwa nkugihangange kandi gihambiriye mubicuruzwa bitandukanye, harimo isosi, imyambarire, na desser. PH y'ibiryo birashobora kuva kuri aside ya alkaline, bitewe nibirumba no gutunganya. Gusobanukirwa imyitwarire ya HEC mubidukikije bitandukanye ni ngombwa mugushikira imiterere yifuzwa, umunwa, no gutuza mubicuruzwa byibiribwa.

Mu nganda zubwubatsi, Hec akoreshwa mubisabwa nka minisiteri yo gucika intege, imyitozo, kandi ihimbaza ko kugumana amazi no kugenzurwa. PHI y'aya mafranga irashobora gutandukana bitewe nibintu nko gukira hamwe no kubaho kwongonge. Kunoza PH umutekano wa PHC ni ngombwa kugirango ubone imikorere no kuramba ibikoresho byubwubatsi.

Guhagarara kwa HydroxyAythyl Cellulose (HEC) mu bidukikije bitandukanye byatewe n'imiterere ya shimi, imikoranire na PH, n'ibisobanuro bifatika mu nganda zitandukanye. Gusobanukirwa imyitwarire ya HEC mubihe bitandukanye PH ni ngombwa kugirango abamubare kugirango basobanure imikorere yayo muburyo butandukanye. Ubundi bushakashatsi burakenewe kugirango dutoroshe uburyo bukurikiranye bugenga umutekano wa Hec no gutegura ingamba zo kuzamura imikorere yayo mubihe bitoroshye PH.