Uburyo bworoshye bwo kuranga hydroxypropyl methylcellse (HPMC)

HydroxyPropyl methylcellse (HPMC) ni polyment polymer ikoreshwa cyane mubuvuzi, ibiryo, kubaka, kwisiga hamwe nizindi nzego. Ifite amazi meza cyane, imitungo ya Colloidal hamwe nubukungu, niyo ifite ibyifuzo byingenzi munganda zitandukanye. Kugirango tumenye neza ubuziranenge nuburinganire, umwirondoro ukwiye urakenewe. Ibikurikira ni uburyo bwinshi bwo kumenyekanisha kuri hydroxyproppopyl methylcellse (HPMC), gupfukirana ibintu nkibigaragara, kwihuta, kwikuramo imiti.

1. Indorerezi
HPMC mubisanzwe yera kuri ifu yera cyangwa ibipimo bya granular, impumuro nziza kandi itaryoshye. Mugukurikirana isura yayo, urashobora gucira urubanza niba ari HPMC nziza. Guhindura ibara iryo ari ryo ryose cyangwa kuba hari umwanda birashobora kwerekana ko icyitegererezo gihumanye cyangwa cyanduye.

2. Kumenyekanisha gukemurwa
HPMC ifite byinshi byonyine, cyane cyane mumazi. Shira umubare muto wicyitegererezo mumazi hanyuma ubyuke witonze. Niba ishobora gushonga vuba kandi ikora igisubizo kimwe cya colloidal, bivuze ko icyitegererezo ari hydroxyPropyl methylcellse. Umuvuduko wo gusesa hamwe na visositity yumuti birashobora kuba bifitanye isano nuburemere bwa moleclar na hpmc hamwe nibiri muri hydroxyPropyl na methyl imiti yimiti.

Muri icyo gihe, kwikeba kwa HPMC mu bicuruzwa kama nabyo birashobora kandi gukoreshwa nkibiranga. HPMC irashonga mubintu byinshi byamarika (nka acetone, ethanol, nibindi), ariko udasuzuguwe mubikemubyo. Ibi biranga birashobora kwemezwa no kugerageza kwikebagura muburyo bukwiye.

3. Kugereranya inzitizi (IR)
Ibiciro bya Infraredscopy (IR) nigikoresho kiranga rwose gishobora gufasha kwemeza imiterere ya HPMC. Ibiranga ibyingenzi bya HPMC nibyo kwinjiza amatsinda nka methyl (-ch3) na hydroxyPropyl (-ch2ch (yewe) ch3). Kubaho kw'aya matsinda birashobora kwemezwa no kwinjiza impinga ya IR.

Ihuba ishingiye ku mpinga ya HPMC ririmo:

2920 cm-1 (ch irambuye vibration)

1450 cm-1 (ch yunamye vibration)

1100-1200 cm-1 (coc irambuye vibration)

3400 cm-1 (yewe kurambura kunyeganyega, agaciro ka peak karashobora guhinduka kubera kuba hari amazi)

Mugereranije ir spectrum yicyitegererezo cya HPMC, irashobora kugereranwa na strectrum yicyitegererezo kitazwi kugirango yemeze umwirondoro wicyitegererezo.

4. Kumenyekanisha imiti
HPMC, nkigiterane cya Ether, gifite ibiranga imiti kandi birashobora kugaragazwa nibisubizo byoroshye bikurikira.

(1) reaction munsi ya acide:
Gushonga cyane hpmc mumazi, ongeraho aside hydrochloric aside, nubushyuhe. Niba ibintu byakorewe muri colloidal bigaragara mubikorwa, bivuze ko ikubiyemo HPMC. Iyi myitwarire irashobora kugaragazwa nubukungu bwa HydroxyPropyle na methyl munsi ya aside.

(2) reaction mubihe bya alkaline: HPMC irashonga mumazi kugirango ikore igisubizo cya colloidal. Ntibyoroshye gushonga mugice cya alkaline (nka sodium hydroxide igisubizo), bifitanye isano namasaha yacyo hamwe na hydrogel ibintu. Niba igisubizo kiranga cyangwa kimeze, bivuze ko HPMC ihari.

5. Kumenyekanisha nuburyo bwa viscosity HPMC ni ikintu gifite ibiranga vicositine, bityo birashobora kumenyekana na viscosity mu gisubizo cy'amazebwe. Muri rusange, HPMC izakora ibintu bya colloidal hamwe ninyenyeri runaka nyuma yo gusezerera mumazi, kandi ubuyoji bwiyongera hamwe no kwiyongera k'uburemere bwa moleki.

Kugirango upime viscosity, amazi yigisubizo cya HPMC kirashobora gupimwa no gukoresha amashusho ya robitwari cyangwa ikirahure. Ukurikije uburemere bwa HPMC na kwibanda kubisubizo, ubuyobe bwayo burashobora kugereranywa. Niba virusi yicyitegererezo irenze cyane kurenza igisubizo cya HPMC, irashobora kwerekana ko ibintu byayo byanduye cyangwa uburemere bwa molecular ni buke.

6. Melting Point / Ikizamini cya Deccomcation Port HPMC, nkikigo kinini cya molecular, mubisanzwe ntabwo gifite ingingo isobanutse, ariko izerekana koroheje cyangwa kubora mugihe cyo gushyushya. Igihe HPMC ishyushye, impinduka zayo kubushyuhe butandukanye. Muri rusange, HPMC izatangira kubora saa 180-200 ℃, irekura ibintu bimwe bihindagurika (nk'amazi na kama). Impinduka muri porokireri irashobora kwemeza niba icyitegererezo ari cyiza HPMC.

7. Kukemeranya nubusa bwa tension
Igisubizo cyashinzwe nyuma ya HPMC ishonga muri rusange ifite impagarara zo hasi. Amakimbirane yubuso yigiti cya HPMC arashobora gupimwa ukoresheje tensiometero cyangwa uburyo butonyanga. Niba ihuye nubutaka bwimisoro isanzwe, bivuze ko icyitegererezo ari HPMC.

Ibyavuzwe bitangiza uburyo bwinshi kandi bworoshye bwo kumenya hydroxyproppopyl methylcellse (HPMC). Ubu buryo bugaragaza HPMC kuva ku mpande nyinshi nko kugaragara, kwikuramo imiti, ubushyuhe, ukuri kandi kweza icyitegererezo cyagenwe, gutanga garanti yacyo mu nganda zitandukanye.