HydroxyPropylmethylcellcellCelcellsellsellsells (HPMC ni polymer ikoreshwa cyane muri farumasi ya farumasi kubera kunyuranya, biocompasogisi, n'imitungo mikorere. Ariko, gusaba ntabwo bifite aho bigarukira nibibazo. Harimo imitungo ya fiziki, gutunganya ibibazo, ibibazo bituje, kugenzura ibikorwa bifatika nibisohoka. Gusobanukirwa izo mbogamizi ni ngombwa kubashakashatsi hamwe nabakora imiti kugirango batsinde inzitizi kandi bategure imikorere ya HPMC.
HydroxyPropylmethylcellcellCellCellsellsellselilose (HPMCI NYINSHI ikoreshwa mumyitozo ya farumasi kubera uburyo butandukanye bwo gukoresha, harimo na binder, ahinduranya, kandi agenzurwa umukozi urekura. Nubwo byari byamamare, gukoresha HPMC byerekana aho ubushobozi runaka bugarukira hamwe ningorane zigomba gukemurwa kugirango hamenyekane iterambere ryatsinze neza nubucuruzi.
1.Fical na shimi:
HPMC ifite imiterere yihariye yumubiri, nkibikesha, vicosiya, no kwitwara nabi, nibyingenzi binini mubikorwa byayo muri farumasi muri farumasi. Ariko, ibi biranga birashobora kandi guteza ibibazo mubihe bimwe. Kurugero, viscosiya ibisubizo bya HPMC biterwa cyane nibintu nkubushyuhe, PH, hamwe nigitero cyo gusiganwa, bishobora kugira ingaruka kumiterere yo gutunganya mugihe cyo gukora. Byongeye kandi, ibyokuntu bya HPMC birashobora kugabanya ibyateganijwe muri sisitemu zimwe zo gutanga ibiyobyabwenge, cyane cyane mumashusho asaba gusenya byihuse.
2. INGORANE ZITANGIRA:
Gutunganya HPMC birashobora kuba ingorabahizi kubera hygroscopique nyinshi no kumva mubihe bibi. Hygroscopique irashobora gutera ibibazo nkibikoresho bifunze kandi bidahuye nifu mugihe cyo gukora nka granulation na table. Byongeye kandi, kumva HPMC kugirango uhindure ubushyuhe nubushyuhe bisaba kugenzura ibitekerezo byitonderwa kugirango ibicuruzwa bihuze neza kandi bihamye.
3. Ibibazo byuzuye:
Guhagarara ni ikintu gikomeye cya farumasi, kandi HPMC irashobora gutanga ibibazo bimwe na bimwe bihamye, cyane cyane muri sisitemu ya equeous. Kurugero, HPMC irashobora kunyuramo hydrolysise ya acide, biganisha ku kwangirika kwa polymer hamwe nibishobora guhinduka muburyo bwo gutereka mugihe. Byongeye kandi, imikoranire hagati ya HPMC n'abandi bitwazo cyangwa ibikoresho bifatika bya farumasi (APIS) birashobora kugira ingaruka ku gicuruzwa cya nyuma, kwerekana ko ubushakashatsi buhuje buri gihe mu iterambere ryamagana.
4. Ubugenzuzi:
Ibidukikije bishinzwe kugenzura ibidukikije bijyanye no gukoresha HPMC muri farumasi ni ikindi kintu kigomba gusuzumwa. Mugihe HPMC ifatwa nkumutekano (Gras) ukurikije ibigo bishinzwe kugenzura nka FDA, hashobora kuba ibisabwa byihariye cyangwa ibibujijwe bitewe no gukoresha nuburyo bwagenewe. Byongeye kandi, impinduka mubuyobozi cyangwa amahame ngenzuramikorere birashobora kugira ingaruka kubikorwa cyangwa ibyemezo byo kwemererwa kubicuruzwa bya HPMC, bisaba kubahiriza hamwe nimbaraga zinyandiko kubakora.
5.
Urebye aho imbogamizi n'ingorane za HPMC, abashakashatsi n'abakora barimo gushakisha ubundi polymes n'abavandimwe. Ubu buryo bushobora gutanga inyungu nko gutura neza, imyirondoro yo kurekura ibiyobyabwenge, cyangwa kugabanya ibibazo byo gutunganya. Ingero zirimo ibikomoka kuri selile, nka Ethylcellse cyangwa methycellsellse, na methycellsellse, na synthetic polymeti, nka polyvinyl inzoga (pva) cyangwa polyethylene glycol (peg). Ariko, gukoresha ubundi buryo byibanzi bisaba neza umutekano wabo, imikorere yabo, no guhuza nibindi bikoresho muri formulate.
HydroxyPropylmethylcellcellCellCellse (HPMC) ni polymer ifite agaciro muri farumasi, ariko ikoreshwa ryayo ntabwo ari imbogamizi nibibazo. Gusobanukirwa no gukemura izo mbogamizi ni ngombwa kugirango utezimbere imikorere no gutuza ibicuruzwa bya HPMC. Mugusuzuma witonze imiterere yumubiri, gutunganya ibibazo, ibibazo byumutekano, ibibazo byo kugenzura, abashakashatsi ndetse nabakora ibicuruzwa hamwe nibikoresho byuzuye muri FPMC muri pharmaceutics.
Igihe cyagenwe: Feb-18-2025