Hpmc synthique cyangwa karemano?

HydroxyPropyl MethylcellUlose (HPMC) ni urugo rutandukanye rukoreshwa mu nganda zinyuranye, kuva muri farumasi mu kubaka. Imitungo na Porogaramu byatoroshye kwitondera cyane, biganisha ku mbogamizi zayo no kubahiriza-byumwihariko, niba ari synthique cyangwa karemano.

1. Gusobanukirwa hydroxyPropyl methylcellse (HPMC)

HPMC ni uguta kumiterere ya chimique ya selile, mubisanzwe biboneka muri Polyssacride iboneka murukuta rwakagari bwibimera. Bikomoka kumiterere ya selile hamwe na proflene okiside hamwe na methyl chloride, bikaviramo imitungo idasanzwe itandukanye ninza ya precursor.

2. Inzira ya Synthesis

Synthesis ya HPMC ikubiyemo intambwe nyinshi. Mu ntangiriro, selile yakuwe mu masoko y'ibimera nk'ibiti cyangwa ipamba. Iyi selile ikorwa na alkali kugirango ikore selile ya alkali. Nyuma yaho, imyanda ya proplone na methyl chlorisi ivugwa muri selile ya alkali iyobowe, biganisha ku gusimbuza amatsinda ya hydroxyl hamwe n'amatsinda ya hydroxyle na hydroxyPropy na methisle. Urwego rwo gusimbuza (DS) rugena imitungo ya HPMC yavuyemo, harimo viscosiya, kudusaba, no mu myitwarire yubushyuhe.

3. Imiterere ya molekale

Imiterere ya HPMC igereranya urunigi rw'umurongo w'ibice bya glucose, bin kuri selile, hamwe n'amatsinda ya hydroxyPropyl na methyl yometse kuri hydroxyl (-Oh) imyanya. Ibisimbuza biva hydrophobicity na steric inzitirwa, guhindura imiterere yumubiri nubuhebyi bya polymer. Impamyabumenyi no gukwirakwiza izi gusimburwa bigira ingaruka kumiterere ya Polymer, bigatuma habaho porogaramu zitandukanye.

4. Porogaramu ya HPMC

HPMC isanga akamaro nini mu nganda zinyuranye kubera imitungo yihariye:

Imiti yicals: Muri farumasi, HPMC ikora nkibintu bikomeye muri sisitemu yo gutanga ibiyobyabwenge, harimo na tableti, capsules, hamwe nibitera byingenzi. Ikora nka bunder, mocofier ihinduranya, na firime yahoze ari film, irengera igenzura ryibikoresho byingenzi bya farumasi (APIS) no kuzamura ibarwamu.

Kubaka: HPMC ikoreshwa mubikoresho byubwubatsi nka minisiteri yo gucikamo, inzara, na tile. Irakora nkubumuga, abakozi bangamiwe namazi, hamwe nuburyo bwo guhindura abantu, kunoza ibikorwa, kurokora, no kuramba byibicuruzwa byanyuma.

Inganda zibiribwa: HPMC yemerewe gukoreshwa nkibiribwa, cyane cyane nkumubyimba, stabilizer, na emalulizer mubiryo bitandukanye byatunganijwe, harimo amasosi, ibiryo, nibikomoka ku mata. Kamere yacyo yo gutahura no kubura uburozi bukayifite umutekano kugirango ukoreshe.

Ibicuruzwa byita ku giti cye: HPMC yinjijwe mu kwisiga, guhumura uruhu, no kwita ku misatsi yo kwitondera film yacyo, kubyimba, no guhungabanya umutungo. Izinganya ibicuruzwa, isura, n'imikorere idatera uburakari.

5. Synthetic vs

Ibyiciro bya HPMC nka sintetike cyangwa karemano ni impaka. Ku ruhande rumwe, HPMC ikomoka kuri selile, mubisanzwe bibaho polymer nyinshi mubimera. Ariko, guhindura imiti bigira uruhare muri synthesis-guhinduka hamwe na proplone okiside na methyl chloride-ibisubizo mubintu byahinduwe muburyo bwahinduwe muri mugenzi wacyo. Byongeye kandi, inzira yo gukora ya HPMC ikubiyemo imyitwarire yimiti yinganda, ishobora guteza impungenge kubijyanye no gutondekanya nkibicuruzwa bisanzwe.

Abashyigikiye ibyiciro bya sintetike bavuga ko guhindura imiti bikorerwa kuri selile bihindura mu kigo gitandukanye hamwe nibiranga synthique. Bashimangira uruhare rwa synthetike no gutunganya mubyakozwe na HPMC, bagaragaza ko bava muri selile isanzwe.

Ibinyuranye, abunganira ibyiciro bisanzwe byerekana ko HPMC igumana imiterere yibanze ya selile, nubwo ihinduka. Bavuga ko kuva selile ikomoka ku masoko zishobora kuvugururwa, HPMC irashobora gufatwa nk'inkomoko y'ibisanzwe. Byongeye kandi, bashimangira ko guhindura imiti bigira uruhare muri synthesi yigana muri kamere bibaho muri kamere, nubwo muburyo bugenzurwa n'inganda.

6. Ibitekerezo byo kugenzura

Uhereye kubitekerezo byubuyobozi, ibyiciro bya HPMC biratandukanye bitewe nububasha nububasha. Mu turere tumwe na tumwe, nk'Umuryango w'ubumwe bw'ibihugu by'Uburayi na Amerika, muri Amerika, muri rusange HPMC ifatwa nk'umutungo kamere ukomoka kuri selile. Nkibyo, bigengwa n'amabwiriza agenga ibiyobyabwenge, abababarira imiti, ndetse n'abisanzwe.

Nyamara, imibiri imwe yubuyobozi irashobora gushyiraho ibisabwa byihariye cyangwa ibibujijwe ku ikoreshwa rya HPMC rishingiye ku gusaba no gutangazwa ubuziranenge. Kurugero, icyiciro cya farumasi kigomba kubahiriza ibipimo ngenderwaho byerekeranye no kwezwa, kugaragara, no kubura umwanda kugirango umutekano wabyo nibikorwa birimo ibiyobyabwenge.

7. UMWANZURO

HydroxyPropyl MethylcellllAlose (HPMC) ifite uruhare runini mu nganda zinyuranye, iterwa n'imiterere yacyo itandukanye. Mugihe synthesis yayo irimo guhindura imiti isanzwe ibaho, impaka zikikije ibyiciro byayo nkibice bya sintetike cyangwa bisanzwe. Abashyigikiye ibitekerezo byombi batanga ibitekerezo bifatika, byerekana intera igoye hagati yimiti, imiterere yimiterere, hamwe ninkomoko karemano.

Tutitaye ku byiciro byayo, HPMC ikomeje guhabwa agaciro kubera imikorere yayo, umutekano, no kuramba. Nk'iterambere ry'ubushakashatsi hamwe n'ubuyobozi bushinzwe kugenzura imitungo n'inkomoko ya HPMC bizaba ngombwa mu gufata ibyemezo mu nganda, mu Rwanda, ndetse n'ibigo bishinzwe kugenzura.