Hpmc hydrophilic cyangwa lipophilic?

HydroxyPropyl Methylcellsellus (HPMC) ni polymer ikoreshwa cyane hamwe nibisabwa bitandukanye mubuvuzi, ibiryo, kwisiga no kubaka. Ikibazo cya hydrophility na lipophilitity ya HPMC ahanini biterwa nuburyo bwa foto yimiti na molekeries.

Imiterere yimiti hamwe numutungo wa HPMC
HPMC ni nkomoko itari ionic wakozwe mugutangiza amatsinda ya hydroxyle na methyl mumiterere ya selile. Urunigi rwayo rufite hydroprisique rwa hydrophilic (-Oh) na methyl (-Ch3) na hydroxyPropyl (-ch2ch (yewe) amatsinda ya ch3). Kubwibyo, ifite amafirimbi abiri, hydrophilic na lipophilic, ariko hydfiliriti yiganje gato. Uyu mutungo uraduha cyane, gushiraho film hamwe na film.

Hydrophilicity ya HPMC
Kubera umubare munini wamatsinda ya hydroxyl mumiterere ya HPMC, urunigi rwarwo rufite hydrofile. Mu mazi, HPMC irashobora gukora isuku ya hydrogen, yemerera molekile gushonga mumazi no gukora igisubizo kinini. Byongeye kandi, HPMC ifite kandi ihagarikwa ryiza ry'amazi kandi rikoreshwa cyane nk'umubyimba n'intangarugero mu buvuzi, ibiryo n'ibisiga. Kurugero, HPMC irashobora gukoreshwa nkumukozi urekuye mu myiteguro ya faruceti yo gutinza igiyobyabwenge cyibiyobyabwenge mumubiri no kunoza umutekano wibiyobyabwenge.

Lipophilicity ya HPMC
Amatsinda ya methyl na hydroxyPropyl muri molekile ya HPMC ifite hydrophobity, bityo HPMC ifite na lipofili cyangwa muburyo buke cyangwa ibiti byoroheje kugirango bibe igisubizo gihamye. Sipophilintity yayo ituma kuvanga nibintu bimwe na bimwe bya petero, byongera ubushobozi bwa HPMC mumazi-mumazi (o / w) emulsions na latexes. Mu kwimura bimwe cyangwa imyiteguro ishingiye kuri HPMC ifasha gushinga uburyo butapimwe kimwe hamwe nibintu bya hydrophobic, bityo bigamije gukwirakwiza no gutuza ibintu.

Gusaba HPMC
Imyiteguro ya farumasi: HPMC ikunze gukoreshwa nkibikoresho bikomeza kugaragara mubisate, ukoresheje hydrofilirity yacyo hamwe numutungo wa firime wo kugenzura igipimo cyo kurekura ibiyobyabwenge.
Inganda zibiribwa: Mubiryo, HPMC ikoreshwa nkuwabyimbye n'amazi yo kwagura ubuzima bwibiryo kandi akanoza uburyohe.
Ibikoresho byubaka: Amazi ya HPMC yoroheje no kuniha imibyinire abigira sima, kuzamura ibikorwa bya minisiteri mu kubaka, kuzamura imikorere namazi ubushobozi bwibikoresho.
Kwisiga: Mubicuruzwa byita ku ruhu, HPMC irashobora gukoreshwa nka EmulsiFier Stabilizer. Kubera hydrofilire yayo, irashobora gukora matrix ya matrix kugirango igumane ingaruka zigufatamo hamwe nuburyo bwibicuruzwa.
HPMC ni ibintu bya amphilic bifatika bya hydrophilic na lipophilic, ariko kuberako bifite amatsinda ya hydfilixy nyinshi, bigaragaza hydrofili ikomeye.