1.. Ibintu by'ibanze bya HPMC
HYPROMMELLOSE, izina ryicyongereza HydroxyPropyl Methylcellse, Alias HPMC. Formulala yayo ni c8h15o8- (c10hl8o6) n-c8hl5o8, kandi uburemere bwacyo ni igice cya kabiri nigice cya polyhydroxypropyl ether ya selile. Irashobora gukorwa nuburyo bubiri: imwe nuko urwego rukwiye rwa methyl selile rwafashwe na Nahih, hanyuma bakirana ibyapa byapanze ubupfura munsi yubushyuhe nigitutu. Ifishi ihujwe nimpeta ya anhydroglucose ya selile, kandi irashobora kugera kurwego rwiza; Ibindi ni ugufata ipamba cyangwa fibre yimbaho hamwe na soda ya Caustic, hanyuma wibonere methyl chloride na methyl chloride na proflone HPMC ni ibintu bitandukanye bya selile, kandi nibyinshi bya farumasi, bifite amakuru menshi. Kugeza ubu, ikoreshwa cyane murugo no mumahanga, kandi nimwe mubaruta imiti ifite igipimo cyo gukoresha hejuru mubiyobyabwenge.
Iki gicuruzwa ni cyera kugeza amata yera mumabara, adafite uburozi kandi butaryoshye, kandi iri muburyo bwa granular cyangwa fibrous ifu itemba byoroshye. Birahagaze neza muburyo bworoshye bworoshye kandi buhebuje. Byarabyimbye mumazi akonje kugirango akore amata yera ya colloidal yera, afite uruhara runaka rwabasura, kandi phenomenon yo guhuza Sol-gel guhuza kwibanda kubitekerezo byikibazo. Birashonje cyane muri 70% cyangwa dimethyl Ketone, kandi ntazashonga inzoga zuzuye, chloroform cyangwa ethoxyhane.
Iyo PH ya Hypromellose iri hagati ya 4.0 na 8.0, ifite umutekano mwiza, kandi irashobora kubaho muburyo bwa PH iri hagati ya 3.0 na 11.0. Iyo ubushyuhe ari 20 ° C hamwe nubushuhe ugereranije ni 80%, bibikwa muminsi 10. Ubushuhe bukoreshwa muri HPMC ni 6.2%.
Kubera ibikubiye muburyo butandukanye bwa gukoresha na hydroxyProppopyl muburyo bwa hyppimellose, ubwoko butandukanye bwibicuruzwa byagaragaye. Mubisobanuro byihariye, ubwoko butandukanye bwibicuruzwa bifite ubushyuhe bwihariye nubushyuhe bwo hasi, bityo, bifite imitungo itandukanye kandi ishobora gukoreshwa mumigambi itandukanye. Phareasiya y'ibihugu bitandukanye bifite amategeko atandukanye n'ihagarariye ku moderi: Porokayi y'Abanyaburayi, ukurikije amanota atandukanye ya virusi itera ibicuruzwa. Muri Amerika ya Pharmacopoeani, Pharmacopoeia zunze ubumwe za Amerika, izina rusange ryongerera imibare 4 kurangiza kugirango werekane ibiri ku ijanisha rya metero 2208, imibare ibiri ya nyuma ihagarariye hydroxyProppoyl ijanisha rya hafi rya.
2. Uburyo bwo gushonga HPMC mumazi
2.1 Uburyo bwamazi ashyushye
Kubera ko hypromellose idashonga mumazi ashyushye, irashobora gutatana rimwe mumazi ashyushye mugitangiriro, hanyuma arakonja. Uburyo bubiri busanzwe busobanurwa kuburyo bukurikira:
.
.
Uburyo bwo kuvanga.
Ifu ya powder iratatana byuzuye numye kuvanga hamwe nibindi bikoresho bingana cyangwa byinshi bitandukanye, hanyuma bishonga mumazi. Muri iki gihe, hypromellose irashobora gushonga nta magglomeration.
3. Ibyiza bya HPMC
3.1 Amazi akonje
Gushonga mumazi akonje munsi ya 40 ° C cyangwa 70% Ethanol, bidahwitse mumazi ashyushye hejuru ya 60 ° C, ariko irashobora gutontomerwa.
3.2 Indorerezi yimiti
HYPROMMELLOSE (HPMC) ni ubwoko bwa selile idahwitse. Igisubizo cyayo ntigifite ionic kandi kidakorana ninyungu zumunyu cyangwa ibintu kama. Kubwibyo, abandi bababarira ntibabyitwaramo mugihe cyo kwitegura.
3.3 Guhagarara
Birahagaze neza kuri aside na alkali, kandi birashobora kubikwa igihe kirekire hagati ya PH 3 na 1L nta mpinduka igaragara muri viscosity. Igisubizo cyamazi ya hypromellose (HPMC) ifite ingaruka zo kurwanya Lowe-Lowew kandi zirashobora gukomeza umutekano mwiza mugihe cyo kubika igihe kirekire. Farumasi yo gukoresha HPMC nkabababaye bafite ubuziranenge bwiza kuruta abatsinze abatsinze gakondo (nka Dextrin, ibisimba, nibindi).
3.4 Ibyahishuwe
Ibiryo bitandukanye bya HPMC birashobora kuvangwa hakurikijwe ibipimo bitandukanye, kandi urusyo rwayo rushobora guhinduka ukurikije amategeko amwe, kandi rufite umubano mwiza wumurongo, bityo ikigereranyo gishobora gutorwa ukurikije ibisabwa.
3.5 Metabolic Inetia
HPMC ntabwo yinjijwe cyangwa metabolize mumubiri, kandi ntabwo itanga ubushyuhe, niko imyiteguro yumutima itekanye.
3.6 Umutekano
Muri rusange bizera ko HPMC ari ibintu bitari uburozi kandi bidatera uburakari. Igipimo cya Median cyica kuri imbeba ni 5g / kg, hamwe na median yica ingano yimbeba ni 5.2g / kg. Dosiye ya buri munsi ntabwo itwaye kubantu.
4. Gusaba HPMC mugutegura
4.1 Nka firime yo gutwikira ibikoresho nibikoresho byo gukora firime
Ukoresheje hypromellose (HPMC) nkibikoresho bya tablet ya firime, ugereranije nibinini gakondo nkibisate byimiti, ariko imbaraga zabo, gusebanya, gusenya inyungu nibindi bipimo nibyiza nibyiza nibyiza. Icyiciro gito-cyerekana iki gicuruzwa gikoreshwa nkigikoresho cyo gukosora amazi yibinini nibinini, hamwe nicyiciro kinini-gikoreshwa nkibikoresho byo gupfundikira firime. Kwibanda mubisanzwe ni 2.0% kugeza kuri 20%.
4.2 Nka Binder no Gutandukanya
Icyiciro cyo hasi cyiki gicuruzwa kirashobora gukoreshwa nkainder kandi zidasobanutse kubinini, ibinini, na granules, hamwe nicyiciro kinini cyo gukoreshwa cyane nkurwego. Ibipimo biratandukanye hamwe nibisabwa bitandukanye. Mubisanzwe, dosage ya binder kubinini byumye ni 5%, hamwe nigipimo cya binder kubinini bya granulation itose ni 2%.
4.3 Nkumukozi wahagaritswe
Umukozi wahagaritswe nigice cya villas hamwe na hydrophilitity, gishobora kudindiza umuvuduko wimigabane mugihe ukoreshwa mubutaka bwo gukumira ibice byo gukumira no kugabanuka mumupira. Guhagarika abakozi bafite uruhare runini muguhagarika guhagarikwa. HPMC nubu bwoko bwiza bwo guhagarika, kandi igisubizo cya colloidel cyashengejwe gishobora kugabanya impagarara zimikoreshereze yubusa nimbaraga zubusa, bityo zikangurira ituze rya sisitemu yo gutatanya ubuziraherezo. Icyiciro cyo hejuru cyiki gicuruzwa gikoreshwa nkigishushanyo mbonera cyamazi gitegurwa nkumukozi wahagaritswe. Ifite ingaruka nziza yo guhagarika, biroroshye gusubiramo, ntabwo akomeza kurukuta, kandi afite ibice byiza bya flot. Dosage isanzwe ni 0.5% kuri 1.5%.
4.4 Nka Blocker, Yakomeje-Kurekura Umukozi hamwe na Pore
Icyiciro cyo hejuru cyiki gicuruzwa gikoreshwa mugutegura hydrophilic Gel Matrix yakomeje-kurekura ibisate bya matrix ivanze-birekura ibinini, kandi bifite ingaruka zo gutinza ibiyobyabwenge. Gukoresha kwibanda ni 10% ~ 80% (w / w). Amanota make akoreshwa nkabakozi ba pore kugirango arekure cyangwa agenzurwa-agenzurwa. Igipimo cyambere gisabwa kugirango ingaruka zimpeshyi zubu bwoko bwa tablet zirashobora kugerwaho vuba, hanyuma zigashyire ahagaragara cyangwa ngo zirekurwe cyangwa kwibanda ku biyobyabwenge byamaraso bibungabungwa mumubiri. Iyo HYPPROMELLOSE yunamye amazi, yigana gukora gel. Uburyo bwo kurekura ibiyobyabwenge muri tablet ya Matrix ahanini ikubiyemo kugabanura igice cya gel hamwe nisuri yigice cya gel.
4.5 gukingira gukingira nka Thickeneri na Colloid
Iyo iki gicuruzwa gikoreshwa nkuwabyimbye, ibitekerezo bikunze gukoreshwa ni 0.45% ~ 1.0%. Iki gicuruzwa kirashobora kandi kongera imbaraga za hlue ya hydrophobike, kora colloid irinda, irinda uduce duto dutongana no guhinga hashyizweho ishyirwaho rya sediment, kandi kwibanda bisanzwe ni 0.5% ~ 1.5%.
4.6 ibikoresho bya capsule kuri capsules
Mubisanzwe capsule igishishwa capsule ya capsule ishingiye kuri gelatin. The production process of the gelatin capsule shell is simple, but there are some problems and phenomena such as poor protection against moisture and oxygen sensitive drugs, low drug dissolution rate, and delayed disintegration of the capsule shell during storage. Kubwibyo, Hyppimellose, nkumusimbura wa Gelatin Capsules, ikoreshwa mugutegura capsules, itezimbere ubushobozi no gukoresha ingaruka za capsules, kandi yazamuwe murugo no mumahanga.
4.7 Nka Bioadheshesive
Ikoranabuhanga rya Bioadhesion, ikoreshwa ry'abarinzi hamwe na bioalmes hamwe na aoshion kuri Mucosa y'ibinyabuzima, mu buryo bworoshye bwo kwitegura na Mucosa. Kuri ubu irakoreshwa cyane cyane ikoreshwa mugufata indwara zubwato bwamazuru, Mucosa yo mu kanwa nibindi bice. Ikoranabuhanga rya bioadhesille ni sisitemu nshya yo gutanga ibiyobyabwenge yateye mumyaka yashize. Ntabwo ari ugukiza igihe cyo guturamo gusa ni imyiteguro ya farumasi mu rupapuro rwa farumasi mu rupapuro rwa Gastrointestinal, ariko kandi izamura imiti iri hagati y'ibiyobyabwenge na chrverrane ku biyobyabwenge, mu buryo bwo kuzamura ibiyobyabwenge ku maraso y'ibikombe.
4.8 nka gel yo hejuru
Nkitegura imyifatire y'uruhu, Gel ifite urukurikirane rwinyungu nkumutekano, ubwiza, isuku yoroshye, igiciro gito, gahunda yo kwitegura, no guhuza neza nibiyobyabwenge. icyerekezo.
Igihe cyagenwe: Feb-14-2025