Bifata igihe kingana iki kuri HPMC yo gushonga?

HPMC (HydroxyPropyl methylcellse) ni polymer isanzwe ikoreshwa mugutegura ibisate bya farumasi, ibitonyanga byamaso nibindi bicuruzwa. Igihe cyabwo kiterwa nibintu byinshi, harimo uburemere bwa molekile, ubushyuhe bwigisubizo, umuvuduko ukabije no kwibanda.

1. Uburemere bwa molekile hamwe nurwego rwo gusimbuza
Uburemere bwa molekile nurwego rwo gusimbuza (ni ukuvuga uburyo na hydroxyPropyl ibirimo) bya HPMC bizagira ingaruka ku kuntu gukemuka. Muri rusange, ingano nini yuburemere bwa molekile, igihe kinini gifata kugirango ishonge. Ubushyuhe buke HPMC (uburemere buke bwa molecular) mubisanzwe bifata iminota 20-40 kugirango ishonge ubushyuhe bwicyumba, mugihe uburemere bwinshi bwa HPMC (uburemere bwinshi bwa molecular) bushobora gufata amasaha menshi kugirango bashongeje burundu.

2. Ubushyuhe
Ubushyuhe bwimico bugira ingaruka zikomeye ku gipimo cy'imivugo ya HPMC. Ubushyuhe bwo hejuru mubisanzwe bwihutisha inzira yo gusebanya, ariko ubushyuhe buri hejuru cyane burashobora gutera gutesha agaciro HPMC. Ubushyuhe bubi busabwe muri rusange butari hagati ya 20 ° C na 60 ° C, kandi amahitamo yihariye ashingiye kubiranga HPMC n'intego yo gukoresha.

3. Umuvuduko ukabije
Gukangurira birashobora guteza imbere iseswa rya HPMC. Gushishikazwa neza birashobora kubuza agglomeration n'imvura kuri HPMC kandi bikatatatana neza mubisubizo. Guhitamo umuvuduko ukabije bigomba guhindurwa ukurikije ibikoresho byihariye nibiranga HPMC. Mubisanzwe, ibisubizo bishimishije birashobora kugerwaho mugukurura iminota 20-40.

4. Igisubizo
Kwibanda kuri HPMC nabyo ni ikintu cyingenzi muguhitamo igihe cyo kuvuka. Isumbabyose kwibanda, igihe kirekire kirimo igihe kirekire ni. Kubisobanuro bike (<2% W / W) Ibisubizo bya HPMC, igihe cyo kuvugurura gishobora kuba kigufi, mugihe igisubizo cyo kwibandaho bisaba igihe kinini cyo gushonga.

5. Guhitamo Soluvent
Usibye amazi, HPMC irashobora kandi gushonga mubindi bicuruzwa nka ethanol na rotyne glycol. Polarity no kukecuruzwa kw'ibintu bitandukanye bizagira ingaruka ku gipimo cy'ivumburwa cya HPMC n'ibiranga igisubizo cya nyuma.

6. Uburyo bwo Gutegura
Uburyo bumwe bwo kwitegura, nko gukubita HPMC cyangwa gukoresha amazi ashyushye, birashobora gufasha kwihutisha inzira yo gusebanya. Byongeye kandi, gukoresha ibikoresho byo kuvugwa nkabasiwe bikabije birashobora kandi guteza imbere imikorere yo gusebanya.

Igihe cyo kuvura cya HPMC kigira ingaruka kubintu byinshi. Kubwibyo, mubikorwa bifatika, ibishya byivumburwa bigomba guhinduka ukurikije ibisabwa byihariye nibiranga HPMC. Mubisanzwe, igihe gisabwa kuri HPMC kugirango ishongejwe mubihe bikwiye kuva muminota 30 kugeza kumasaha menshi. Kubicuruzwa byihariye bya HPMC nibisabwa, birasabwa kwerekeza kumabwiriza yibicuruzwa cyangwa imyitwarire yubushakashatsi kugirango umenye ibihe byiza byivumburwa nigihe.