Nigute hpmc itanga vicosi ihamye?

HydroxyPropyl Methylcellsellse (HPMC) nicyo kitari ionic, gushonga amazi ether bikunze gukoreshwa mu nganda zitandukanye nka farucetic, ibiryo, kwisiga, no kubaka. Kimwe mu biranga byari bikomeye nubushobozi bwayo bwo gutanga visosi ihamye mubisubizo hamwe namashusho. Uburyo bwihishe inyuma yubushobozi bwa HPMC bwo gukomeza kugaragara kandi buhoraho kandi burashobora kumvikana no gusuzuma imiterere yabyo, imikoranire namazi, nimyitwarire mubihe bitandukanye.

Imiterere ya molekuleri no kukesha
HPMC ikomoka kuri selile, polymer karemano igizwe na glucose ifitanye isano na β-1,4-glycosic. Inzira yo guhindura irimo gutangiza uburyo na hydroxypropyl amatsinda ya selile, bikaviramo hydroxyPropyl methylcellse. Iyi miterere yongerera imbaraga za HPMC mumazi na kama.

Urwego rwo gusimbuza (DS) hamwe no gusimbuza umuryango (MS) nibipimo bikomeye bisobanura imiterere ya HPMC. DS ivuga impuzandengo yimibare ya hydroxyl yasimbuwe igice cya anhydroglucose, mugihe ms yerekana umubare witsinda ryitsinda ryandika kuri Mole ya Anhydroblucose. Ibipimo bigira ingaruka ku bushobozi bwa HPMC, imiterere yubushyuhe, na vino.

Uburyo bwo Guhuza vicosicy
Hydration na Gel gushiraho:
Igihe HPMC yongewe kumazi, ihura na Hydration, aho molekile y'amazi yinjira kandi ikorana n'iminyururu ya polymer, bigatuma babyimba. Iyi moteri ya Hydration iganisha kumurongo wa gel utanga umusanzu mubisubizo. Handration iterwa n'ubushyuhe, PH, no kuba hari umunyu, ariko imiterere ya molect ya HPMC yemerera gukora uruganda ruhamye rwa gel.

Uburemere bwa molekile na polymer imikoranire:
Uburemere bwa molekile ya HPMC igira ingaruka zikomeye cyane. Ibiro byo hejuru bya molecmer bifite iminyururu miremire, bizirikana byoroshye, byongera vicosi yumuti. HPMC iraboneka mumanota atandukanye hamwe nuburemere bwa molekari, yemerera kugenzura neza viscosiya kubicuruzwa byanyuma. Kwishora hamwe no gukora iminyururu ya polymer birema urusobe rutanga ubushyuhe buhoraho.

Ingano yubushyuhe:
HPMC yerekana ibintu bidasanzwe bya pelation yubushyuhe, aho ikora gel ashyushya kandi akemeza igisubizo kirimo gukonjesha. Aya mafarasi ahinduka aturuka muburyo bwa memoxy na hydroxppeyl, uburyo bwo kuzamura imikoranire ya hydrophobike ku bushyuhe bwo hejuru, biganisha kuri Gel. Iyo ukonje, iyi mikoranire iragabanuka, kandi geel irashonga. Uyu mutungo ningirakamaro cyane muri porogaramu zisaba impinduka zishingiye ku bushyuhe mugihe ukomeje gushikama muri rusange.

Imyitwarire yuburyo:
Ibisubizo bya HPMC byerekana imyitwarire idahwitse, inanga, isobanura uko bigaragara kwabo igabanuka hamwe no kongera imigenzo. Uyu mutungo ubyemeza ko mubihe bitandukanye byo gutunganya, nko kuvanga cyangwa kuvoma, viscosity yo ibisubizo bya HPMC iramenyekana mugihe cyimbere mugihe imbaraga zumwimerere mugihe imbaraga zayo zumwimerere mugihe imbaraga zumwimerere zivanyweho. Iyi myitwarire ya thixotropic ifasha kugumana ubusumbane buhoraho mugihe cyo gusaba.

ph ituze:
Bitandukanye nibindi byinshi polmers, HPMC iratumva kuri PH impinduka murwego rwa 3 kugeza 11. Uku guturika kuri kamere itari izwi, bikabuza gufata acide cyangwa ibishingwe. Nkigisubizo, HPMC ikomeza ubukana buhoraho hirya no hino ph, bigatuma bikwiranye na porogaramu zitandukanye aho PH ishobora guhinda.

Gusaba kungukirwa no kwerekana ubudahwema
Farumasi
Muri farumasi, HPMC ikoreshwa nkuwabyimbye, binder, kandi agenzurwa-add. Inzitizi zayo zihoraho ningirakamaro mu kwemeza ibiyobyabwenge bimwe byo kugabana ibiyobyabwenge, guhagarikwa bihamye, no kumwirondoro wateganijwe. Kurugero, muri tablet Coatings, HPMC iremeza neza, ndetse no kuyishyira mu bikorwa, no mubisubizo bya Ophthalmic, itanga ubunini bukenewe bwo guhura igihe kirekire nijisho.

Inganda
Mu nganda z'ibiryo, HPMC ikora nka Emulsifier, Stabilizer, na Trickener. Ubushobozi bwayo bwo gutanga visosi buhoraho ni ngombwa mugukomeza imiterere no gutuza ibicuruzwa nka sosiki, imyambarire, hamwe nibintu byamata. Ibikoresho bya permal bya HPMC bifite akamaro cyane mubicuruzwa bisaba impinduka za vino mugihe cyo guteka.

Kubaka
Mu bikoresho by'ubwubatsi, HPMC ikoreshwa muri sima na plaster bigize kunoza ibikorwa, kugumana amazi, no kumeneka. Ibyerekanwe bihoraho byemeza ko ibyo bikoresho bishobora gukoreshwa neza no gukomeza ubunyangamugayo mugihe cyo gukira.

Kwisiga
HPMC ikoreshwa mubitera byihishe kubibyimba kandi bikatera imbaraga. Mubicuruzwa nka cream, cream, na shampoos, virusi ihamye iremeza imiterere ishimishije kandi ituje, kuzamura uburambe bwabakoresha.

Ibintu bireba urujijo no kugenzura ubuziranenge
Ibintu byinshi birashobora guhindura viscosiya ibisubizo bya HPMC, harimo kwibanda, ubushyuhe, no kuba hari electrolytes cyangwa izindi nyandiko. Kugirango ugere kuri viscosity, ni ngombwa kugenzura ibipimo mugihe cyo gushyiraho no gutunganya. Ingamba zo kugenzura ubuziranenge zirimo:

Guhitamo Ibikoresho BEW:
Kwemeza ko ikoreshwa rya selile itunganijwe hejuru no gukomeza impamyabumenyi ihamye yo gusimburwa no gusimbuza kumena ni ngombwa kugirango akore SPMC imitungo yizewe.

Ibikorwa byo gutunganya:
Inzego zigenzurwa, zirimo kugenzura neza uko ibintu byahinduwe mugihe cyo guhinduranya, ni ngombwa mugutanga HPMC hamwe nuburemere bwa molecular buhoraho hamwe nuburyo bwo gusimburwa.

Ikizamini cyo gusesengura:
Ikizamini cyo gusesengura gisanzwe cya HPMC yirukana viscosity, gukwirakwiza ibiro bya molecular, no gusimburwa uburyo bufasha kurinda ibicuruzwa. Tekinike nka viscometry, Urubanza rwa Gel Chromatografiya, hamwe na ruguru ya magnetic ya rukuruzi ya rukuruzi isanzwe ikoreshwa.

Ububiko no Gukemura:
Ububiko bukwiye no gukoresha HPMC kugirango birinde ubushuhe no gutesha agaciro ni ngombwa. HPMC igomba kubikwa mubikoresho bya airtight kandi mubihe byiza, byumye kugirango bikomeze imitungo.

Ubushobozi bwa HPMC bwo gutanga ibiti bihamye bikomoka kumiterere yihariye ya molekelar, imiterere ya hydtion, hamwe nimyitwarire ya gelation. Ihungabana ryaryo kuri VER itandukanye ya PH, ibintu byoroheje, hamwe n'imikorere yizewe mubihe bitandukanye bituma habaho polymer itabishaka mu nganda nyinshi. Binyuze mu kugenzura neza imikorere yumusaruro hamwe ningamba zuzuye zuzuye, abakora neza ba HPMC bemeza ko iyi polymer itandukanye ikomeje guhura nibisabwa na porogaramu zinyuranye.