Nigute hpmc igira ingaruka kumutekano wo guhagarikwa?

HydroxyPropyl methylcellsellse (HPMC) ni amazi asanzwe akoreshwa na selile yakoreshejwe cyane mu guhagarikwa. Guhagarara byo guhagarikwa bivuga ubushobozi bwibice bihamye kugirango tugacire rumwe mu buryo bumwe bwatatanye mu buryo burebure butagira ingano cyangwa gutera imbere. Imiterere idasanzwe yumubiri na shimi ya HPMC ituma igira uruhare runini mugutezimbere umutekano wo guhagarikwa.

Ibintu by'ibanze bya HPMC

Umubiri na shimi
HPMC ni ko bakomokamo byabonetse na Methylation igice na hydroxy opepy of selile. Imiterere yayo ikubiyemo Hydrophilic Hydroxyl (-Oh) na hydrophobic memoxy (-OCH₃) hamwe namatsinda ya hydroxyPropyl, bituma amazi ashonga HPMC irashobora gukora igisubizo cya viscous mumazi, kandi urusyo rwarwo ruhinduka hamwe nubushyuhe, ubushyuhe na PH.

Ibiranga Viscosity
Igisubizo cya HPMC yerekana imitungo y'amazi atari ashyantare, kandi ubuswa bwacyo bugabanuka hamwe no kongera imigenzo yo kwiyongera, ni ukuvuga ko igaragaza imitungo yoroheje. Uyu mutungo ufite uruhare runini kumyitwarire yuburyo bwimiterere kuko irashobora gutanga vicosity ikwiye kubuza imyanda mugihe kitari viccous cyane mugihe kigenda cyangwa gusuka.

Uburyo bwo kugira ingaruka za HPMC kumutekano wo guhagarikwa

1. Ingaruka zijimye
Ingaruka zijimye za HPMC nukubuza imyanda yibice bikomeye mu kongera viscosiya. Ingaruka zikabije zigaragarira cyane mubice bikurikira:

Kongera ubuswa bwumuco: HPMC irashobora kongera ubushishozi bwimbaraga zo guhagarikwa, bityo bikagabanya igipimo cyimyanya yimiterere ikomeye mumazi. Ni ukubera ko ukurikije amategeko yo kubika, igipimo cy'imiterere y'ibice ni kigereranyije mu buryo butandukanye kuri viscosiya. Kwiyongera muri viscometity birashobora gutinda neza gutandukana ibice no kuzamura itunganijwe ryihagarikwa.

Gukora imiterere yimiyoboro itatu: HPMC irashobora gukora imiterere isa na gel mumazi, ishobora gufata no gukosora ibice bikomeye kandi ikababuza gutura. Iyi miterere yububiko ikomezanyweho nububiko bwa hydrogen hamwe nuburyo bwa hydrophobike, kugumana ibice bimwe bitatanye.

2. Ingaruka ya electrostatique
Imiterere ya HPMC itwara amafaranga runaka (urugero, binyuze muri hydroxyl cyangwa hydroxyl cyangwa hydroxyPropyl amatsinda), ashobora gusabana nubuso bwabashinzwe ibice bikomeye mu ihagarikwa. Muguhindura ubushobozi bwo hejuru bwibice, HPMC irashobora kongera ingwate electrostatica hagati yimiterere, bityo irinde gukusanya no gusenya ibice.

Kwishyuza ingaruka: Ushinzwe HPMC irashobora guhindura hejuru yubuke bwuzuye ibice, ongera ingwate electrostatike hagati yingingo, kandi ugabanye impengamiro yo gukusanya.

Guhungabanya sisitemu ya colloidal: Muri sisitemu zimwe za Colloidal, muri sisitemu zimwe za Colloidal, HPMC irashobora gufasha ahantu hatatatatanye hejuru kandi ukababuza kwiyongera kubera kwiyongera kubera imbaraga za Van der Waaling

3. Ingaruka za Steric
Molekile ya HPMC irashobora gukora urugendo rwa bariyeri mu ihagarikwa, ishobora gukumira umubiri no gukusanya imibonano n'iterambere hagati y'ibice, bityo bituma habaho guhagarikwa.

Inzitizi ya spatial: molekile ya HPMC igira igice cyo gukosora ahantu hakomeye, bishobora kubuza umubiri kwegera, bigabanya amahirwe yo kwiyongera no kwiteranya.

Guhagarara ku gahato: Bitewe na molekile ya HPMC, guhuza ibitekerezo hagati yagabanutse, kandi iyi mbogamizi yumubiri yemerera ibice byahagaritswe kugirango bikomeze rimwe mugihe kirekire.

4. Igikorwa cyo hejuru
Igikorwa cyo hejuru cya HPMC kibyemerera kwamamaza hejuru yibice bikomeye kugirango bibe igiterane. Uku gutwita ntirutera isoni gusa ibice, ahubwo binatezimbere hydrophilicity yibice, bikorohereza gutatanya mubitangazamakuru byamazi.

Guhindura hejuru: Nuguhindura hejuru yibice, HPMC irashobora guhindura imitungo yumubiri nu miti yimiti yubutaka no kongera itahabijwe kandi ituze kubice.

Mugabanye impagarara zihuza: Igikorwa cyo hejuru cya HPMC kirashobora kugabanya impagarara zihuza hagati yuburyo bwamazi hamwe nubutaka, byoroshye ibice bitatatana muburyo budakwirakwizwa.

Ingero za porogaramu ya HPMC muburyo butandukanye

Guhagarika ibiyobyabwenge
Mu guhagarikwa ibiyobyabwenge, HPMC ikoreshwa kenshi mu gutuza imiterere ya farumasi ikora imiti. Muguhindura uburemere bwibanze na moleki, ibintu byimvugo byahagaritswe birashobora kugenzurwa, kugirango ibigize ibiyobyabwenge bikomeze gukwirakwizwa mugihe cyo kubika no gukoresha, kugenzura ubudakemuro.

Mu guhagarikwa mu kanwa ka antibiyotike zimwe na zimwe cyangwa ibiyobyabwenge bya antibacteri, HPMC ikoreshwa nk'ubumwe bwo gukumira imyanda y'ibiyobyabwenge mu gihe gutanga uburyohe n'amazi.

Guhagarika guca udukoko
Mu guhagarikwa imiti yica udukoko, HPMC irashobora kunonosora ibitandukanye byerekana uduce duca udukoko mu mazi no kugabanya kubitsa imiti yica udukoko, bityo bigatuma imikorere n'imikorere yo gukoresha imiti yica udukoko.

Mu udukoko cyangwa udukoko twica udukoko, HPMC irashobora gukoreshwa nk'ahantu upatanye kandi wijimye kugira ngo tumenye ko ibigize imiti yica udukoko bishobora gutangwa cyane mugihe cyo gusaba no kunoza ingaruka zo kurinda ibihingwa.

Ibiryo no guhiga kwisiga
Mu masoko n'inganda zo kwisiga, HPMC ikoreshwa cyane nk'intago kandi ikabyimbye. Kurugero, mubicuruzwa nkibimurwa cyangwa amavuta, HPMC irashobora kunoza imiterere yibicuruzwa no gukumira imiti no kugwa.
Muri cream yuruhu, hpmc irashobora gukoreshwa nkababyimbye byoroshye kandi ugamura ingaruka zidasanzwe, kugirango ibintu bifatika bitangwe neza, kandi ituze nibikorwa byibicuruzwa byanonosowe.

HPMC igira ingaruka ku mikorere ihagarikwa binyuze muburyo butandukanye, harimo n'intwaro yongera imbaraga, kuzamura ingaruka zamashya, gutanga imbogamizi ya steric no gukora hejuru. Ubu buryo bukorera hamwe kugirango Hpmc igikoresho cyiza cyo kuzamura umutekano wihagarikwa. Ibisabwa byayo mubice byubuvuzi, imiti yica udukoko, ibiryo nibisiga byemeza ibyiza byayo nkintangarugero. Mu bihe biri imbere, nk'uko ibyifuzo byo guhagarikwa bikomeje kwiyongera, ubushakashatsi no gukoresha HPMC bizakomeza kurushaho.