Nigute abahanga muri selile bakoreshwa mu nganda za farumasi?

Abashiraho selile bakoreshwa cyane mu nganda za farumasi, kandi imitungo yabo idasanzwe yumubiri nubumaji ibakora igice cyingenzi cyimyiteguro ya farumasi.

1. Kugenzurwa no gukomera kwitegura
Abatanga selile, nka hydroxyPropyl methylcellus (HPMC) na sodium carboxymethyl selile ya selile (cmc-na bikoreshwa mugukemura igipimo cyibiyobyabwenge. Barashobora gukora gel igice cyo kongera kurera ibiyobyabwenge ugenga urugero rwa diffusi na ibiyobyabwenge. Mugukoresha erega hamwe nisuka zitandukanye na dogeresi yo gusimburwa, umubare wibiyobyabwenge mumubiri birashobora kugenzurwa neza, bityo bigenzurwa neza no kugabanya imiti.

2. Kurema capsules nibinini
Abatanga selile bagira uruhare runini mubikorwa byo gukora ibinini hamwe na capsules nka binders no gukora abakozi. HPMC na CMC-NA bakunze gukoreshwa nka bunders kugirango batere tableting itaziguye kubera amazi yabo meza no kubyutsa. Barashobora kongera ubuto bwiza no gukomera kw'ibinini, kuzamura imbaraga za mashini z'ibisate, no kwemeza neza ibinini mu nzira ya gastrointestidinal.

3. Abari barabike n'intangarugero
Abashiraho selile bakoreshwa nkabariba n'intangarugero mu myiteguro y'amazi. Barashobora kongera viscolity yumuti no kunoza ihagarikwa no gutuza ibiyobyabwenge. Kurugero, CMC-NA akenshi ikoreshwa mu guhagarikwa mu kanwa na creamique yo mu kanwa kugira ngo birinde imyanda no kugashyirwa mu bikorwa ibiyobyabwenge, bityo bigatuma uburinganire no gutuza.

4. Ibikoresho byo gutwika byinjira
Bamwe mu bahanga muri seliki, nk'igitugu berekanwa (EC), akenshi bikoreshwa mu bikoresho byo ku nkombe byinjira bitewe no kwihanganira ibidukikije. Ihuriro ryinjira rishobora kurinda ibiyobyabwenge kubonwa muri aside gastric no kurekura ibiyobyabwenge mumara. Ibi birashobora kubuza ibiyobyabwenge kurimburwa mu gifu no kunoza ibinyabuzima byabiyobyabwenge.

5. Ibikoresho bya bioashi
Abashiraho selile barashobora gukurikiza imiti yibinyabuzima, bikaba ngombwa mugutegura imyiteguro ya biohad. Imyiteguro y'ibinyabuzima irashobora kurangira igihe cy'ibiyobyabwenge aho ibikorwa byo gukora no kongera ibitekerezo byaho, bityo bigatera imiti. Kurugero, HPMC ikunze gukoreshwa mugutegura amazina hamwe nimyiteguro ya Mucoltmic hamwe nimyiteguro ya Mucosal yo mu kanwa, ishobora kongera igihe cyibiyobyabwenge hejuru yubuso bwa ocular hamwe na Mucosa yo mu kanwa.

6. Ibikoresho
Abahanga ba selile bakunze gukoreshwa nkibikoresho byo gukorerwa kugenzura ibiranga ibiyobyabwenge no kuzamura ibiyobyabwenge. Ubugari bwa Colliulose Coatings birashobora kurinda ibiyobyabwenge ingaruka zibidukikije, nkubushuhe na ogisijeni, no kwagura ubuzima bwibiyobyabwenge. Byongeye kandi, muguhindura ubunini bwa cote no gushyiraho, ibiyobyabwenge birashobora kurekurwa mugihe cyagenwe kandi muburyo bugamije.

7. Kuzamura no guhagarika abakozi
Mu myiteguro igoye y'ibiyobyabwenge, abakoresha selile barashobora gukoreshwa nk'abashinzwe kuzamura no guhagarika abakozi kugira ngo bateze imbere imikorere no gutuza ibiyobyabwenge. Kurugero, mubiyobyabwenge byinshi nibiterwa na selile, bahanganye na selile barashobora kubuza imyanda ibiyobyabwenge no kuzamura uburinganire no gutuza kubisubizo byibiyobyabwenge.

8. Abababaye
Abashiraho na selile na bo bakoreshwa mu gutegura abababaye, nk'ibinini bisesagura byihuse kandi bikureho ibisate. Aba bimukira barashobora guhindura igipimo cyivumburwa no kurekura ibiranga ibiyobyabwenge, kuzamura ibinyabuzima bya bioakwaiLauld na sekuruza. Kurugero, HPMC ikoreshwa cyane mugutegura ibinini byihuta cyane, bishobora gusimbuka byihuse nyuma yo guhura namazi, byorohereza abarwayi gufata.

9. BiocompUbility n'umutekano
Ubumwe bwa Cellulose bafite biocompat neza n'umutekano byiza, kandi birashobora kwandura ibintu bitagira ingaruka mumubiri, bigabanya ingaruka mbi kumubiri wumuntu. Kubwibyo, ubumwe bwa selile bukoreshwa cyane mubikorwa byimiti kandi bibaye igiteranyo cyiza kubwimigambi itandukanye.

Gusaba selile ether mu nganda za farumasi zipfunyitse igenzurwa-isohoka kandi ikureho imyiteguro, ibikoresho byo gutwikira, ibikoresho byo kunyerera, ibikoresho byo gutwikira, ibikoresho byo gusiga, ibikoresho byo gusiga. Imiti yacyo idasanzwe yumubiri nimiti yimiti igira ingaruka mbi kandi yingenzi mumiteguro ya farumasi, yateje imbere iterambere ryikoranabuhanga rya farumasi no kuzamura ibiyobyabwenge.