Ibintu bireba ubuzima bwa HPMC

HydroxyPropyl MethylcellAllLese (HPMC) ni ibintu byinshi mbonera byimiti bikunze gukoreshwa muri farumasi, ibiryo, kwisiga, ibikoresho byubwubatsi. Ubuzima bwabwo bwerekeza ku burebure bwigihe bushobora kugumana umutungo wacyo, imiti n'imikorere mubihe byihariye. Ibintu bigira ingaruka ku buzima bwa HPMC burimo imiterere y'ibidukikije, imiterere yo kubika, gutuza imiti, n'ibindi.

1. Imiterere y'ibidukikije
1.1 Ubushyuhe
Ubushyuhe nimwe mubintu byingenzi bireba ubuzima bwa HPMC. Ubushyuhe bwo hejuru buzahita bwihutisha reaction ya HPMC, bikaviramo impinduka mumiterere yumubiri na shimi. Kurugero, HPMC irashobora guhindura umuhondo ikagabanya urusyo mu bushyuhe bwinshi, bigira ingaruka ku mikorere yayo. Kubwibyo, ubushyuhe bwibidukikije HPMC aho hagomba kubikwa mu bushyuhe buke, muri rusange munsi ya 25 ° C, kwagura ubuzima bwayo.

1.2 Ubushuhe
Ingaruka zubushuhe kuri HPMC ifite akamaro kanini. Hpmc ni ibikoresho bya hydrophilic byerekana ko bikurura ubuhehere. Niba ubushuhe mububiko burebure cyane, HPMC izakuramo ubuhehere mu kirere, bigatuma habaho ubushuhe mu kirere, bituma habaho ubushuhe mu kirere, bituma habaho ubushuhe mu kirere, bituma habaho ubushuhe mu kirere, bituma habaho ubushuhe mu kirere, bituma habaho ubushuhe mu kirere, bituma habaho urusiku. Kubwibyo, HPMC igomba guhora yumye mugihe ibibi, kandi birasabwa ko ubushuhe ugereranije bugenzurwa buri munsi 30%.

2. Imiterere yo kubika
2.1 Gupakira
Ibikoresho byo gupakira no gushyirwaho ingaruka zigira ingaruka mubuzima bwa HPMC. Ibikoresho byo gupakira neza birashobora gutandukanya umwuka nubushuhe kandi birinde HPMC kubona bitose no kwangirika. Ibikoresho bikunze gukoreshwa harimo imifuka ya aluminiyum, imifuka ya polyethylene, nibindi, bifite inzitizi nziza. Mugihe kimwe, gupakira bifunze neza birashobora kugabanya imibonano ya HPMC hamwe nibidukikije byo hanze no kwagura ubuzima bwayo.

2.2 Kumurika
Umucyo, cyane cyane ultraviolet irradiation, irashobora gutera gutesha agaciro HPMC kandi bigira ingaruka kumubiri no mumiti. Iyo uhuye numucyo igihe kirekire, HPMC irashobora guhinduka ibara, urunikiro rwa molekile, nibindi rero, HPMC igomba kubikwa mubidukikije-byerekana ibimenyetso cyangwa gukoresha ibikoresho byo gupakira bidapakira.

3. Imiti Yumuti
3.1 PH agaciro
Guhagarara kwa HPMC bigira ingaruka cyane ku gaciro ya PH. Mu bihe bya acide cyangwa alkaline, HPMC izakora hydrolysis cyangwa imyifatire yo gutesha agaciro, biganisha ku bibazo nko kugabanuka kwa victositike n'impinduka muke. Kugirango HPMC ishishikarizwe, irasabwa ko agaciro kwo mu gisubizo cyayo kigenzurwa mu ntera yo kutabogama (PH 6-8).

3.2 Amabanga
Kuba hari umwanda bigira ingaruka kumiti ya HPMC. Kurugero, umwanda nkicyuma gishobora guhamagarira uburyo bwo gutesha agaciro HPMC, kugabanya ubuzima bwayo. Kubwibyo, ibihurira kwanduye bigomba kugenzurwa cyane mugihe cyimikorere nigikoresho gifite isuku hejuru kugirango habeho gukusanya HPMC.

4. Ifishi y'ibicuruzwa
Uburyo bwibicuruzwa bya HPMC bigira ingaruka ku buzima bwayo. HPMC mubisanzwe ibaho muburyo bwifu cyangwa granules. Ingaruka zimiterere itandukanye kubuzima bwayo ni nkibi:

4.1 Ifishi y'ifu
Ifishi ya HPMC ifite ubuso bunini kandi bufite hygroscopique kandi yanduye, bityo ubuzima bwayo ni bugufi. Kugira ngo uhindure ubuzima bw'ifu ya HPMC, gupakira bifunze bigomba gushimangirwa kwirinda guhura n'umwuka n'ubushuhe.

4.2 Ibice bya morphology
Ibice bya HPMC bifite ubuso buto bwihariye, ni hygroscopique nkeya, kandi mugire ubuzima burebure. Ariko, HPMC ya GPMC irashobora kubyara umukungugu mugihe cyo kubika no gutwara abantu, bikavamo ubuzima bugufi bugabanijwe. Kubwibyo, Granular HPMC isaba kandi gupakira neza no kubika.

5. Koresha inyongeramuzi
Kugirango utezimbere umutekano kandi wongere ubuzima bwa HPMC, abigabye, abanyabyaha cyangwa kubungabunga biterwa mugihe cyo kubyara. Kurugero, ongeraho antioxidants zishobora kwirinda gutesha agaciro HPMC, no kongeramo abakozi basuramo ubushuhe bishobora kugabanya hygroscopity ya HPMC. Ariko, guhitamo no gutanga umusaruro bigomba kugenzurwa cyane mubushakashatsi bukomeye kugirango tumenye neza ko badahindura imitungo n'umutekano wa HPMC.

Ubuzima bwa HPMB bugira ingaruka kubintu byinshi, harimo imiterere y'ibidukikije (ubushyuhe, ubushuhe (gupakira imiti (ingufu z'amashusho (ifu, granules) no gukoresha inyongeramusaruro. Kugirango wongere ubuzima bwibintu bya HPMC, ibyo bintu bigomba gufatwa nkingamba zikwiye kandi bigomba gufatwa ingamba zo kugenzura. Kurugero, kubungabunga ubushyuhe buke nububiko bwumye, koresha igisubizo cyiza cyane, gukemura PH, kubungabunga ibintu bifatika, nibindi bikaba byaguwe neza kandi imikorere yacyo irashobora kwizerwa.