Ibintu bigira ingaruka kuri vicosity ya HPMC

HydroxyPropyl methylcellse (HPMC) ni ugusiga selile bikoreshwa cyane cyane mumirima yibikorwa byubaka, imiti, ibiryo no kwisiga. Uruzinduko rwa HPMC ni kimwe mu bipimo by'ingenzi bigize ingaruka kuko bigira ingaruka ku buryo butaziguye amazi, guhindura imitungo, gatelika n'ibindi biranga ibikoresho. Kubwibyo, gusobanukirwa ibintu bireba viscosity ya HPMC ni ngombwa kubisabwa nibishushanyo mbonera byibicuruzwa mubice bitandukanye.

1. Ingaruka z'uburemere bwa molekile
Uburemere bwa Molekolar ya HPMC bugira ingaruka zikomeye kuri viscosity. Uburemere bunini bwa molekile, hejuru cyane viscosiya. Ibi ni ukubera ko HPMC yuburemere bunini bwa molekile ikora imiterere yumurongo utoroshye mubisubizo, byongera amakimbirane imbere yigisubizo kandi biganisha ku kwiyongera muri vino. Muri icyo gihe, uburemere bunini bwa molekile nabwo buzahindura impinduka zikomeye mu gisubizo mugihe cyimikorere, ari ngombwa cyane kugena imikorere yo kurema, ihinga nibindi bikorwa. Ubushakashatsi bwabashakashatsi kandi bwerekanye ko vinosiyo nuburemere bwa molec bugaragaza nabi, ni ukuvuga ubushyuhe ntabwo bwiyongera kumurongo nkuko uburemere bwa molekale bwiyongera.

2. Ingaruka zurwego rwo gusimbuza
Urwego rwo gusimbuza hydroxyproppopyl (-ch3chohch2-) na methyl (-ch3) amatsinda muri HPMC ni ikintu cy'ingenzi kigira ingaruka ku kuntu kwikebana no gusby. Urwego rwo gusimbuza bivuga umubare w'amatsinda ya hydroxyl (-Oh) ku ruhererekane rwa HPMC rwasimbuwe na hydroxyPropyl na methyl. Iyo urwego rwo gusimbuza amatsinda ya hydroxyPropyle rwiyongera, imikoranire hagati ya HPMC izacika intege, kandi iminyururu ya moleki irazagabanuka kwiyakira mu gisubizo cy'amazebwe, bityo yongera vicosiya c'igisubizo; Mugihe kwiyongera kwa methyl bizakunda kongera hydrophobity yumuti, bikaviramo kwishyurwa bigabanuka, bityo bigira ingaruka ku rubyiruko. Mubisanzwe, HPMC ifite urwego rwo hejuru rwo gusimbuza rufite ibibazo byinshi byo kwikebanukirana no gukomera, kandi birashobora kubahiriza ibishishwa bike mubikorwa bitandukanye.

3. Ingaruka zo gukemura
Ibyatsi byo gukemura HPMC bifitanye isano rya bugufi no kwibanda. Mugihe kwibanda kubisubizo biriyongera, imikoranire iri hagati ya molekiri iriyongera cyane, bigatera viscositity igisubizo cyo kuzamuka cyane. Kumwanya muto, molekile ya HPMC ibaho muburyo bwinyungu imwe, kandi viscosity irahinduka neza; Iyo kwibanda bigeze ku gaciro runaka, molekile ya HPMC izishyura kandi igahuza hamwe, ikora imiterere, bituma habaho urutonde rwiyongera. Byongeye kandi, kwiyongera kwimibanire nabyo bizatera HPMC kwerekana imisatsi yuzuye, ni ukuvuga ko bigaragara ko iziyongera mu gikorwa cy'ingabo nyinshi.

4. Ingaruka zubwoko bwa Solvent
Ubwoko bwa Solvent nayo ifite ingaruka zingenzi kubakemuke no guscosity ya HPMC. HPMC irashobora gushonga mumazi hamwe namashusho ami (nka methanol, ethanol, acetone), ariko ibishushanyo bitandukanye bifite ibibazo bitoroshye kandi bidatandukanye. Mu mazi, HPMC isanzwe ibaho muburyo bwo hejuru bwa virusire, mugihe mubikemuro bya kama byerekana ubukuru bwo hasi. Ubukorikori bwa porven bugira ingaruka zikomeye kuri viscolity ya HPMC. Gukemura hamwe na polarity yo hejuru (nk'amazi) izamura hydration ya molekile ya HPMC, bityo yongera vinosiya. Ibicuruzwa bidafite polar ntibishobora gushonga byimazeyo HPMC, bituma igisubizo cyo kwerekana visositity visositity cyangwa iseswa rituzuye. Byongeye kandi, guhitamo no kugereranya ibyuma bifatika bizana bigira ingaruka zikomeye kumikorere ya HPMC.

5. Ingaruka z'ubushyuhe
Ubushyuhe nimwe mu bintu nyamukuru bigize ibidukikije bigira ingaruka kuri viscosity ya HPMC. Mubisanzwe, viscosity ya HPMC iragabanuka nkubushyuhe bwiyongera. Ni ukubera ko ubushyuhe bwo hejuru buzasenya inkumi nindi mikoranire hagati ya HPMC, bityo bigatuma iminyururu ya molekile inyerera cyane, bityo bigabanya urusiku rwikibazo. Ku bushyuhe bumwe, HPMC irashobora no gukorerwa pelation kugirango ikore umurongo uhamye wa gel. Uyu mutungo wa dollal ukoreshwa cyane mubikoresho byubaka hamwe ninganda zibiribwa nkuko itanga viscoestity ikwiye ninkunga yubwibiko. Byongeye kandi, ubushyuhe bufite ingaruka zitandukanye kuri viscosiya hamwe nuburemere butandukanye bwa molekale na dogere. Mubisanzwe, hpmc hamwe nuburemere bunini bwa molekale hamwe na dogere nkuru zubusimbuza nukwumva neza impinduka zubushyuhe.

6. Ingaruka za PH agaciro
Nubwo HPMC ari polymer itabogamye kandi muri rusange itumva kuri PH impinduka, uruspo rwayo rushobora kuba ruracyafite ingaruka mbi (nko mubidukikije bikomeye cyangwa ibidukikije bya alkaline). Ni ukubera ko acide ikomeye cyangwa ibidukikije bya alkali bizasenya imiterere ya HPMC kandi bigabanya umutekano, bikaviramo kugabanuka kwa vino. Kubisabwa bimwe na bimwe, nk'imyiteguro ya farumasi hamwe n'ibiryo bya PH ni ngombwa cyane cyane kugira ngo ubukuru bwa HPMC bugumye mu rwego rukwiye.

7. Ingaruka za ioonic imbaraga
Imbaraga za Ionic mubisubizo kandi zigira ingaruka kumasezerano ya HPMC. Imbaraga nyinshi za ionic zizarinda ibirego muminyururu ya HPMC, bigabanya imyanda ya electrostatike hagati yiminyururu ya molekile, yorohereza molekile zegera, bityo bigabanya ubukuru. Mubisanzwe, mugihe utegura HPMC ibisubizo byicyemezo cya HPMC, intumbero yibandaho igomba kugenzurwa kugirango igenzurwe kugirango ikarito ihamye, ari ngombwa cyane cyane mumikorere ya farumasi no kwisiga.

Uruzinduko rwa HPMC rugira ingaruka kubintu byinshi, harimo uburemere bwa molekile, urwego rwo gusimbuza, ubwoko bwikibazo, ubushyuhe, ubushyuhe, PH agaciro. Uburemere bwa molekile nurwego rwo gusimbuza cyane cyane byerekana ibimenyetso byimbere bya HPMC, mugihe ibintu byo hanze nko gukemura ibibazo, ubwoko bwa Solvent nubushyuhe bigira ingaruka kumikorere yayo mugihe cyo gusaba. Mubikorwa bifatika, ubwoko bwa HPMC bukwiye hamwe nibisabwa kugenzura ukurikije ibikenewe byihariye kugirango tugere ku mikorere myiza ya virusi. Imikoranire yizi ngingo igena imikorere n'imirima ikoreshwa ya HPMC, itanga inkunga idasanzwe yo gusaba kwayo mu kubaka, imiti, ibiryo n'izindi nganda.