HPMC irashonga mumazi?

HydroxyPropyl MethylcellAlose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda zinyuranye kubera imitungo yihariye. Iyi mpapuro irasobanura ibibazo bya HPMC mumazi, imiterere ya shimi, imiterere, porogaramu, nibintu bireba kubuntu. Gusobanukirwa imyitwarire yonyine ya HPMC mumazi ni ngombwa kugirango ikoreshwe neza mumiti yimiti, ibicuruzwa byibiribwa, ibikoresho byubwubatsi, nizindi nganda.

HydroxyPropyl Methylcellsaliose (HPMC) ni igice cya kabiri, polymer ifata amazi yakuwe muri selile. Bikoreshwa cyane mu nganda zinyuranye nka faruceti, ibiryo, kwisiga, kubaka, hamwe nibyambo byimyenda bishingiye kubibyibushye birimo kubyimba, kurimbuka, no gutanga ubushobozi. Ikintu kimwe gikomeye kigena akamaro ka HPMC muburyo butandukanye ni ukudakemura ibibazo byayo.

1.Imiterere n'imiterere ya HPMC
HPMC irimo kuvura selile hamwe na alkali hanyuma itangiza proplene okiside na methyl chloride. Iyi mikorere iva mu gusimbuza amatsinda ya hydroxyl muri parikingi ya selile hamwe n'amatsinda ya hydroxyle na hydroxyPropy na methyl, biganisha ku gushinga amatsinda ya hydrophilic hamwe no kongera ibibazo mu mazi. Urwego rwo gusimbuza (DS) rwa HPMC, bivuga impuzandengo y'amatsinda ya hydroxyl yasimbuwe ku gice cya anhydroblucose, kigira uruhare runini mu kugena imitungo yayo no kukesha. HPMC ifite DS yo hejuru ya DS ikunda gushonga mumazi kubera hydrofilirity yiyongereye.

Umutungo wa HPMC urashobora guhuzwa no guhindura ibipimo nkibiro bya molekile, urwego rwo gusimbuza, hamwe nicyiciro cya vino. Iyi mitungo irimo ubushyuhe, ubushyuhe bwa pelayo, ubushobozi bwo gushiraho firime, hamwe nubushobozi bwo kugumana amazi, bigatuma HPMC ibereye porogaramu zitandukanye.

2.Kongeza HPMC mumazi
HPMC yerekana urugero rwiza rwo kwisubiraho mumazi bitewe nibintu nka DS, uburemere bwa molecular, ubushyuhe, pH, na PH, no kwibanda. Mubisanzwe, hpmc hamwe na ds yo hepfo kandi uburemere bwo hejuru burashonga mumazi ugereranije nabafite uburemere bwa ds na molecular. Ibi byitirirwa hydhiphileility yiyongereye kandi igabanya uburemere bwa molecular, byorohereza imikoranire ya HPMC hamwe na molekile y'amazi, iganisha ku buryo buteye imbere.

Ubushyuhe nabwo bugira ingaruka ku kukengurwa na HPMC mumazi. Ubushyuhe bwo hejuru buteza imbere iseswa rya HPMC kubera imbaraga za kinetic ryiyongereye, biganisha ku kugenda no gukorana na molecular hamwe n'imikoranire y'amazi. Ariko, hari ubushyuhe bukomeye burenze HPMC ishobora kugangirika mu bushyuhe, bigira ingaruka ku buke bwinshi n'umutungo.

PH igira uruhare runini mu kukengurwa na HPMC, kuko bigira ingaruka ku matsinda y'imikorere ahari mu ruhererekane rwa Polymer. HPMC irashonje cyane mumazi atabogamye kuri alkaline ph iringaniye kubera kugabanya imikoranire yimikorere no kongera amatsinda ya hydrophilic, nka hydroxyl na ether ihuza. Muri Acidic Ph, protonasiyo yandi matsinda irashobora kubaho, biganisha ku kugabanuka kwa HPMC mumazi.

Kwibandaho nikindi kintu kigira ingaruka ku kuntutsa HPMC mumazi. Muburyo buke, molekile ya HPMC iratatatanye, yorohereza imikoranire hamwe na molekile y'amazi no guteza imbere kwikemurwa. Ariko, mubihe byibanze, molekile ya hpmc irashobora guteranya cyangwa gukora gels, kugabanya ibikuza mumazi.

3.Gaba HPMC
Kudakemurwa na HPMC mumazi ni ikintu cyingenzi kigena porogaramu zayo mu nganda zitandukanye. Mu nganda za farumasi, HPMC ikunze gukoreshwa nka binder, itunganijwe, filime-film-filime muri tablet muri Tablet, Guhagarika SEPPENIES, hamwe nibisubizo bya Ophthamic, no kugenzurwa-dosiye. Kudakemuwe mumazi yemerera gutatanya byoroshye no gukwirakwiza kimwe muri farumasi, bituma gutanga ibiyobyabwenge ndetse no gukora neza.

Mu nganda zisaga, HPMC ikoreshwa nkuwijimye, stilizer, na emalifie mubicuruzwa nkibisomero, ibyokurya, nibikomoka ku mata. Amazi yonyine ashoboza ishyirwaho rya gels na elimions zihamye, kuzamura imiterere, umunwa, nubuzima bwangiza ibiryo.

HPMC isanga kandi porogaramu mu bikoresho by'ubwubatsi nk'uburebure, minisiteri, na plaster bitewe n'ubushobozi bwo kugumana n'amazi, ibikorwa, hamwe n'ibikorwa bifatika. Kudakemurwa mumazi yorohereza hamles ya sima, bikaviramo guhuza imbaraga nubufatanye bwibikoresho byubwubatsi.

Byongeye kandi, HPMC ikoreshwa mu kwisiga no kwita ku kuntu ku giti cye nk'umukozi wijimye, film - wahoze ari, kandi uhagaze muri cream, amavuta, n'ibikoresho byo kwita ku misatsi. Kudakemuwe mumazi yemerera gushiramo ibintu byoroshye kandi bigatanga imitungo yifuzwa.

4.Abakoraho ingaruka ku buke n'ingamba zo kuzamura
Ibintu bitandukanye bigira ingaruka ku kukengurwa na HPMC mu mazi, harimo na DS, uburemere bwa moleki, ubushyuhe, pH, no kwibanda, nkuko byaganiriweho mbere. Kuzamura ibibazo bya HPMC mu mazi, ingamba nyinshi zirashobora gukoreshwa, nko kwemeza urugero rwo gusimbuza no gutanga ibipimo bya molevelit, ukoresheje PHLOCULT PH, ukoresheje ibyahinduwe mu mubiri nka MicroGrodisation cyangwa Spray yumye.

Nukwitondera kugenzura ibyo bintu no gukoresha ingamba zikwiye, ukecuru wa HPMC mumazi birashobora gutegurwa kugirango usohoze ibisabwa byihariye, wagura akamaro kabwo mu nganda zinyuranye.

HydroxyPropyl Methylcellse (HPMC) ni polymer itandukanye hamwe nibisabwa bitandukanye muri faruceticals, ibiryo, kubaka, kwisiga, nizindi nganda. Kudakemurwa mumazi ni ikintu gikomeye kigena imikorere nigihe cyiza muburyo butandukanye. Gusobanukirwa ibintu bigira ingaruka kubikesha bya HPMC no gukoresha ingamba zo kuzamura ni ngombwa mugukoresha akamaro kayo no gukemura ibibazo byo guhinduka mubintu bitandukanye. Ubundi bushakashatsi no guhanga udushya muriki gice bizakomeza kuzamura ibibazo nibikorwa bya HPMC, bitanga inzira yo kurera kwagutse no gukoresha muburyo butandukanye.