Capsules ikomeye / HPMC Hollow Capsules / Capsules / Imboga-Imikoreshereze-Efficiency API na Moist-Sportike
Ibiciro byibiciro-byiza, byoroshye korohereza gukora, no koroshya ibicuruzwa bya dosage, ibicuruzwa bya oul (osd) bikomeza kuba uburyo bwatoranijwe bwubuyobozi kubateza imbere ibiyobyabwenge.
Muri 38 nshya mu bigo bya molekile bito 38 (Nmes) byemejwe n'ubuyobozi bw'ibiyobyabwenge muri Amerika mu 2019, 26 byari OSD1. Muri 2018, amafaranga yinjiza ibicuruzwa bya OSD hamwe no gutunganya kabiri na Cmos mu Isoko rya Amerika y'Amajyaruguru ryarenga miliyari 69 USD igera kuri 202.
Ibinini biracyaganje ku isoko rya OSD, ariko capsules ikomeye irahinduka ubundi buryo bushimishije. Ibi biterwa nigice cyo kwizerwa kwa capsules nkuburyo bwubuyobozi, cyane cyane abafite ibihangano binini byadukoko. Capsules iruma cyane abarwayi, mask impumuro idashimishije kandi iraryoshye, kandi biroroshye kumira, nziza cyane kurenza izindi mpapuro.
Julien amatara, umuyobozi wibicuruzwa kuri Lonza Capsules hamwe nibikoresho byubuzima, biganisha ku nyungu zitandukanye za capsules hejuru ya taleti. Asangira ubushishozi muri hydroxyroproppepoyl methylcellse (HPMC) Capsules ya Hollow nuburyo ishobora gufasha abategura ibiyobyabwenge uburyo bwo gutegura ibicuruzwa byabo mugihe cyo guhura nabaguzi basaba imiti ikomoka ku gihingwa.
Capsules ikomeye: Kunoza kubahiriza no guhitamo imikorere
Abarwayi bakunze kurwana n'imiti uburyohe cyangwa impumuro mbi, biragoye kumira, cyangwa bishobora kugira ingaruka mbi. Hamwe nibi bizirikana, guteza imbere uburyo bwo gutanga dosiye-urugwiro bishobora kunoza kubahiriza ubuvuzi bwo kuvura. Capsules ikomeye ni amahitamo ashimishije kubarwayi kuko, usibye guhishurira uburyohe n'umunuko, ukagabanya kurekura bikabije, kandi bikagabanya kurekura bikabije, kandi bikaba birekurwa bidatinze, birekura kandi birekurwa kandi birekura buhoro kugirango bigerweho.
Igenzura ryiza hejuru yimyitwarire yibiyobyabwenge, kurugero na micropelletizisi muri API, irashobora gukumira dose guta no kugabanya ingaruka mbi. Abaterankunga bacuruza ibiyobyabwenge barabona ko guhuza ikoranabuhanga mu byinshi hamwe na capsules byongera guhinduka no gukora neza kugenzurwa-birekurwa. Irashobora kandi gushyigikira pellet zirimo ACIS zitandukanye muri capsule imwe, bivuze ko ibiyobyabwenge byinshi bishobora gutangwa icyarimwe mubipimo bitandukanye, bigabanya inshuro zo gukanda.
Imyitwarire ya farumasikotike na farumawodynamike, harimo na sisitemu nyinshi4, spruction sprionisation api3, hamwe na sisitemu yo guhuzagurika5, na sisitemu yo guhuza ibipimo5, nanone yerekanye kubyara neza ugereranije nibitera byiza.
Ni ukubera iki kibazo gishobora kunonosora no kubahiriza ibikorwa no gukora neza isoko risaba granular apis yashyizwe muri capsules ikomeye ikomeje kwiyongera.
Ibyifuzo bya Polymer:
Gukenera capsules imboga kugirango bisimbure gelatin capsules
Capsules gakondo ikozwe muri Gelatin, ariko, Gelatin Capsules irashobora kwerekana ibibazo mugihe uhuye nisuku cyangwa ibihe byiza. Gelatin yakomokaga mu matungo akunze guhuriza hamwe no guhura n'ibitekerezo bigira ingaruka kumyitwarire ivuka, kandi ifite ibintu byinshi ugereranije n'amazi ugereranije no gukomeza guhinduka, ariko ashobora no guhana amazi hamwe na APIS n'abavandimwe.
Usibye ingaruka zikoreshwa ryibikoresho byibicuruzwa, abarwayi benshi kandi benshi ntibashaka gufata ibikomoka ku nyamaswa kubitekerezo byimibereho cyangwa umuco kandi bashaka imiti ikomoka cyangwa ikomoka ku gihingwa cyangwa vegan. Kugira ngo duhuze ibi bikenewe, ibigo bya farumasi nabyo bikomeje gushora imari mu rwego rwo guhanga udushya mu rwego rwo guteza imbere ubundi buryo bushingiye ku gihingwa bufite umutekano kandi bigira akamaro. Gutera imbere mubikoresho siyanse yakomotse ibihingwa bishoboka, itanga abarwayi bakomoka mu matungo hiyongereyeho ku nyungu za Gelatin Capsules - imirimo yo kuzungura, no gukora neza.
Kubwivumbano neza no guhuza:
Gusaba HPMC
Kugeza ubu, bumwe mu buryo bwiza bwo kugenzura Gelatini ni hydroxypropyl methylcellse (HPMC), polymer ikomoka kuri fibre y'ibiti.
HPMC ntabwo ari inert yubuvuzi kuruta gelatine kandi ikanakurura amazi make kuruta Gelatini6. Ibirimo bike bya capsules ya HPMC bigabanya guhana amazi hagati ya capsule nibiri mu bihe bimwe na bimwe bishobora kunoza imiti yimiti no kumubiri, ndetse no guhangana nubuzima bwa Hygroscopic APIS nabababaye. HPMC Hollow Capsules itumva ubushyuhe kandi byoroshye kubika no gutwara.
Hamwe no kwiyongera kwinshi APIS, ibisabwa mubisabwa bigenda bigenda cyane. Kugeza ubu, abategura ibiyobyabwenge bageze ku bisubizo byiza cyane mubikorwa byo gucuraza imikoreshereze ya HPMC yo gusimbuza Capsules gakondo Gelatini. Mubyukuri, muri Assules ya HPMC muri rusange ikunzwe mubigeragezo byubuvuzi kubera guhuza cyane nibiyobyabwenge byinshi nabababaye.
Komeza gutera imbere muri tekinoroji ya HPMC Capsule nayo bivuze ko abaterankunga bashoboye kurushaho bashoboye kwifashisha ibipimo byo gusenyuka no guhuza na nmes nini, harimo ibice bikomeye.
HPMC Capsules idafite umukozi wa dolling afite imitungo yo gusesengura idafite ion na phi kwishingikiriza, kugirango abarwayi bazabona ingaruka zimwe mugihe cyo gufata ibiyobyabwenge ku gifu cyangwa amafunguro. Nkuko bigaragara ku gishushanyo cya 1. 8
Nkigisubizo, kunonosora mu iseswa bishobora kwemerera abarwayi kutagira abahembwa bitera dosiye zabo, bityo rero byiyongera kubahiriza.
Byongeye kandi, gukomeza guhanga udushya muri HPMC Capsule ibisubizo birashobora kandi gushoboza kurekura amarangamutima no kurekurwa byihuse mubice byihuse, bigamije gutanga ibiyobyabwenge muburyo bwa therapeutic, kandi byongera imbaraga za capsules ya HPMC.
Ikindi cyerekezo cyo gusaba kuri Capsules ya HPMC iri mu guhumeka kubuyobozi bwa pulnary. Ibisabwa ku isoko birakomeje kwiyongera kubera ibinyabuzima bitezimbere mukwirinda imbaraga za Hepatike Mbere yo Gutanga Inzira Yubuyobozi Iyo Indwara Zikaba n'indwara zidakira (COPD) hamwe n'ubu buryo bw'ubuyobozi.
Abakora ibiyobyabwenge bahora bashaka guteza imbere igiciro cyigihe gito, gikundana, nubuvuzi bwiza bwindwara zubuhumekero, no gushakishwa imiti yo gutanga ibiyobyabwenge. Icyifuzo kiriyongera.
Ibikubiye mu mazi make ya HPMC bituma biba byiza kuri Hygascopique cyangwa amazi meza ya APIS, nubwo ibintu bya electrostatike hagati yo kwikuramo no kubeshya nabyo bigomba gusuzumwa buri terambere.
Ibitekerezo byanyuma
Iterambere rya siyanse ya Membrane na OSD ryashyizeho umusingi wa HPMC Capsules kugirango tusimbure Gelatin Capsules muburyo bumwe, butanga amahitamo menshi muguhitamo imikorere yibicuruzwa. Byongeye kandi, kwiyongera kwibanda ku byo abaguzi no kuzamuka bisabwa ibiyobyabwenge bihumeka byashizeho ibisabwa na capsules ya Hollow hamwe no guhuza neza na molekile nziza.
Ariko, guhitamo ibikoresho bya membranes ni urufunguzo rwo kwemeza gutsinda ibicuruzwa, kandi guhitamo neza hagati ya Gelatin na HPMC birashobora gukorwa gusa nubuhanga bukwiye. Guhitamo neza ibikoresho bya membrane ntibishobora kunoza imikorere no kugabanya ibintu bibi, ariko kandi bifasha gutsinda ibibazo bimwe.
Igihe cyagenwe: Feb-20-2025