HPMC irashobora gushonga mumazi ashyushye?

HPMC (HydroxyPropyl Methylcellse) Ese gufatwa n'amazi akunze gukoreshwa hagati, akoreshwa cyane mu kubaka, amatara, ubuvuzi, ubuvuzi, ibiryo n'izindi nganda. Iboneka kubishushanyo mbonera bya selile karemano. Ibiranga imiterere byayo bishoboza gukemura igisubizo-hejuru-amazi kandi bifite ikibazo runaka.

HPMC irashobora gushonga mumazi ashyushye?
HPMC irashobora gushonga mumazi ashyushye, ariko inzira yo gusebanya ifitanye isano rya bugufi nibintu nkubushyuhe, ubushyuhe bw'amazi bwo gusenya, uburemere bwa molec, nurwego rwo guhindura. Muri rusange, HPMC irashobora gushonga mu bushyuhe bw'icyumba, ariko igipimo cy'imivucyu yihuta ku bushyuhe bwo hejuru.

1. Mefoliotion
Uburyo bwa HPMC busesagura amazi cyane cyane biterwa na hydrophilition yamatsinda ya hydroxyl na methyl hamwe nitsinda rya propyl muri molekile zayo. Molekile y'amazi irashobora gusabana nitsinda rya hydroxyl na methyl muri molekile ya HPMC binyuze muri hydrogen, kugirango iminyururu ya selile ibuze kandi irangize igisubizo kimwe. Kubwibyo, HPMC ifite amazi meza.

2. Ingaruka zubushyuhe bwo kuvuka kuri relubility ya HPMC
Kudakemurwa na HPMC mubisanzwe biriyongera hamwe nubushyuhe bwiyongera. Muburyo bwo hejuru cyane, imbaraga za kinetic za molekile y'amazi ziriyongera, kandi barashobora gukora neza hamwe nitsinda ryamazi muri molekile ya HPMC, bityo yihutisha inzira zabo zo kuvuka. Cyane cyane kuri HPMC nuburemere bwo hejuru cyane, amazi ashyushye arashobora kugufasha gushonga vuba.

Ariko, ibikundwa bya HPMC ntibiterwa nubushyuhe gusa, ahubwo no muburyo bwo guhindura. Ikigereranyo cya chemique gitandukanye muri molekile ya HPMC igira ingaruka kumazi yoroheje no gutanga ibitsina. Kurugero, HPMC ifite hydroxyleproppopyl ibirimo bifite hydrophilitike bityo rero bishonga byihuta mumazi.

3. Ingaruka z'ubushyuhe bwo hejuru ku gipimo cy'ibisebe
Ku bushyuhe bwinshi, igipimo cy'imivugo cya HPMC kizahita kigaragara. By'umwihariko, mu rwego rwa 60 ° C kugeza 90 ° C, igipimo cy'imivugo cya HPMC cyateye imbere cyane. Ni ukubera ko amazi ashyushye ashobora gusenya neza amazu ya hydrogen hagati ya molekile, yemerera molekile zamazi kwinjira mumiterere ya HPMC yihuta, bityo izamura imvururu zayo.

4. Ibibazo bishobora guhura nabyo mugihe cyo gusesa
Nubwo HPMC ishobora gushonga mumazi ashyushye, niba ubushyuhe ari hejuru cyane, HPMC mubisubizo irashobora kugangirika cyangwa guhinduka muburyo bumwe, cyane cyane iyo uhuye nubushyuhe burebure mugihe kirekire. Ibi birashobora kugira ingaruka kuri viscolity yayo no mubikorwa, cyane cyane mubice bimwe na bimwe bya porogaramu, iyi mpinduka irashobora kugira ingaruka kubwiza bwibicuruzwa byanyuma.

Niba ubushyuhe bwamazi bwongewe mugihe cyo guturika ni hejuru cyane, ifu ya HPMC irashobora gushinga uduce dukora mumazi, bikaviramo gusesengura bituzuye. Kubwibyo, kugirango tumenyeshe kuri HPMC yuzuye, mubisanzwe birasabwa gukoresha amazi ashyushye mugihe cyo gusesa no gufata neza uburyo bukwiye cyangwa ultrasonic afasha muburyo bwo gusebanya.

Ingero zingero zo gusenya amazi ashyushye ya HPMC
Mubyiciro bifatika, amazi ashyushye yo kwikeba kwa HPMC akunze gukoreshwa. Kurugero, mu nganda zubwubatsi, HPMC, nkigikorwa cyingenzi, gishobora gutanga imitima myiza, gukomera no kugumana amazi binyuze mumazi. Mugihe cyo gutegura sima cyangwa minisiteri, HPMC irashobora gufasha kunoza imikorere yubwubatsi no kwirinda kunyeganyega.

Mu nganda za farumasi, HPMC ikoreshwa cyane mu gukora abakozi bahoreye-barekuye abakozi ba capsule kubiyobyabwenge. Kubera amazi meza yoroheje, HPMC irashobora gushonga buhoro buhoro mumubiri wumuntu no kurekura ibiyobyabwenge. Muri ubu buryo, ubushyuhe bw'amazi n'igiciro cy'ibinyuranya cya HPMC bigira uruhare runini.

Mu nganda zibiribwa, HPMC, nk'ibiryo byongeweho, akenshi bikoreshwa nk'ubuhunzi, Emalifier, n'ibindi nyuma yo gushonga mu mazi ashyushye, birashobora gutanga visositimusi, kuzamura uburyohe, biteza imbere uburyohe.

HPMC irashobora gushonga mumazi ashyushye, kandi kukeshanwa kwayo bifitanye isano n'ubushyuhe bw'amazi, imiterere ya moleke ya HPMC, uburemere bwa moleki na guhindura imiti. Ku bushyuhe bwo hejuru, igipimo cy'imivurungano kirahuta, gisanzwe mu rugero rwa 60 ° C kugeza 90 ° C, ingaruka zibangamira ibyiza. Iyo ukoresheje amazi ashyushye kugirango ushishoze HPMC, birakenewe kwitondera kugenzura ubushyuhe bw'amazi nubushyuhe bwo kwivanga kugirango wirinde ingaruka mbi z'ubushyuhe bukabije bwimikorere yacyo.