Hydroxypropyl methylcellse na hypromellose kimwe?

HydroxyPropyl MethylcellUlose (HPMC) na HYPROMMELLOSE ni amagambo akunze gukoreshwa muburyo bumwe, ariko yerekeza kubintu bimwe. HPMC ni inkomoko yubukorikori bwa selile, kandi hyppimlose nizina mpuzamahanga ridaharanira inyungu (Inn) yiki kigo. Aya magambo asanzwe akoreshwa mubikorwa byimiti nibiribwa, mubindi, kubera imitungo yabo itandukanye.

HydroxyPropyl Methylcellse (HPMC) / HYPROMMELLOSE IMITERERE:

HydroxyPropyl MethylcellALese numudendezo wahinduwe. Guhindura bikubiyemo kongeramo hydroxyproppopyle na uburyo kuri selile ya selile. Cellulose ni polysraccharing nyinshi zigizwe nibice bya glucose bihujwe na β-1,4-glycosic. Intangiriro ya HydroxyPropyl (-Och2ch (OH) ph3) na Metch3) Amatsinda yihariye atanga selile, yongerera imitungo yihariye, yongere imbaraga.

Urwego rwo gusimbuza (DS) bivuga umubare ugereranije wasimbuye kuri anhydroblucose igice cya selile. Ku bijyanye na HPMC, itandukaniro muri DS rishobora kuvamo amanota atandukanye hamwe nibintu bitandukanye, bituma biba ibikoresho byoroshye kubisabwa bitandukanye.

Ibiranga hydroxypropyl methylcellse:
Kwishyurwa no guhagarara neza:
HPMC irashonje mumazi hejuru yubushyuhe bwinshi, kandi kwikebagura biterwa nibintu nkurwego rwo gusimbuza nuburemere bwa molekile. Kubaho kwa Hydroxproppopyl na Methoxy trappoyley na Methoxy bigira uruhare mubikesha mumazi akonje, bigatuma bikwirakwira muburyo butandukanye.

Vicosity:
Imwe mumitungo yingenzi ya HPMC nubushobozi bwayo bwo guhindura viscosity igisubizo. Ibyiciro bitandukanye bya HPMC hamwe nibisura bitandukanye birahari bitewe nibisabwa byihariye.

Filime ikora ibintu:
HPMC ikora firime zisobanutse kandi byoroshye, bigakora bifite agaciro mu gukurikiza ibyifuzo munganda n'imiti. Imitungo yo gukora firime ni ingenzi cyane mugukora impapuro zidasanzwe za dosiye hamwe nibitinda.

Gutemba:
HPMC yerekana umutekano hejuru ya ph yagutse, atanga umusanzu mubikorwa byayo muburyo butandukanye. Irwanya uburyo bworoshye bwangiza no kugabanuka kwa microbial, kureba umutekano wibicuruzwa bya farumasi.

Porogaramu y'imiti:
Gukunda Tablet:
HPMC ikoreshwa cyane mu nganda za farumasi kugirango ikore. Guhuza firime Gukora intego zitandukanye, harimo uburyohe, ukinga ibiyobyabwenge mubidukikije, no kurekurwa.

Imyiteguro irambye yo kwitegura:
Kugenzurwa no gusohora ibiyobyabwenge ni ikintu cy'ingenzi mu iterambere ry'ibiyobyabwenge. HPMC ikoreshwa mugushiraho sisitemu ya matrix yemerera gusohora buhoro buhoro ibikoresho byimiti ya farumasi (APIS) mugihe kinini.

Imyiteguro ya Ophthalmic:
Mu majwi, HPMC ikoreshwa mu kongera ubuyobe bw'ijisho ry'ijisho no guhura na prolong hamwe na ocular. Ibi byongera ingaruka zo kuvura ibiyobyabwenge.

Ibyifuzo Byibanze na Transdermal Porogaramu:
HPMC yinjijwe mumibare yibanze nka gels na cream kugirango itange viscosity kandi itezimbere ibicuruzwa. Irakoreshwa kandi mubyiciro bya transdermal kugirango ikemure ibiyobyabwenge binyuze mu ruhu.

Amazi yo mu kanwa:
HydroxyPropyl methylcellse ikoreshwa mu gushyiraho uburyo bwo gutanga imiyoboro yo mu kanwa kugira ngo iteze imbere visi iterabwoba, guhagarika ibice, no guteza imbere padodable.

Gusaba inganda zikoreshwa:
Thuckener:
HPMC ikoreshwa nkumukozi wijimye mubicuruzwa bitandukanye byibiribwa, harimo isosi, imyambarire n'ibiribwa. Ubushobozi bwayo bwo guhindura urusyo bufasha ibicuruzwa byanyuma kugera kumurongo wifuza.

Thuckener:
Mubyifuzo bimwe na bimwe byo gutabwa, HPMC irashobora gukora nkumukozi wa umwe, afasha gukora geles cyangwa gutuza emulis.

Ikirahure n'amakota:
HPMC ikoreshwa mubiryo glazes hamwe no kunoza kugirango atezimbere adhesion, isura no kugumana ubushuhe. Ikora firime ibonerana yongera ubujurire bwibicuruzwa.

Gusimbuza ibinure:
Nka hydrocolloid, HPMC irashobora gukoreshwa nkibinure ibinure mubinure cyangwa ibinure byubusa, gutanga ibyambu hamwe numunwa usa nibicuruzwa bifite ibinure byinshi.

INGORANE n'ibitekerezo:
Mugihe hydroxyPropyl methylcellse nigikoresho gisobanutse gifite ibyifuzo byinshi, hari ibitekerezo nibibazo muburyo bwayo:

Ubushyuhe bumva:
Kudakemurwa na HPMC bigira ingaruka kubushyuhe. Amanota amwe arashobora kwerekana kunanirwa ku bushyuhe bwo hejuru, bisaba ko usuzumwa neza.

Hygroscopique:
HPMC ni hygroscopique, bivuze ko ikurura ubushuhe kuva mubidukikije. Uyu mutungo ugomba gusuzumwa mubitera ahantu heza ni ngombwa.

Guhuza ibiyobyabwenge:
Mubikorwa bya farumasi, guhuza ibiyobyabwenge na polymer ni ngombwa kugirango hazengurwa umutekano nuburyo bwiza bwibicuruzwa byanyuma.

Imiterere rusange:
HydroxyPropyl Methylcellse yakiriwe neza kandi yemejwe ninzego zishinzwe kugenzura ibiryo na Amerika y'ibiyobyabwenge n'ibiyobyabwenge (FDA) n'ibigo by'i Burayi (EMA). Iri kurutonde muri farumacopoe nkicyitegererezo cyemewe kugirango imyiteguro ya farumasi.

HydroxyPropyl Methylcellllse, uzwi cyane nka Hypromellose, ni polymer yo mu mibereho myinshi ifite porogaramu nini mu bijyanye n'inganda. Ibintu byayo byihariye, harimo no kwikunda, guhinduranya ubushishozi, ubushobozi bwo gushiraho firime hamwe nubushobozi bwa firime hamwe, bibe ikintu cyingenzi muburyo butandukanye.

Kuva kuri tablet yo mu bibaho no kurekura-kurekura ibikoresho muri faruceticals ku bibanza n'ibinure bisimbuye ibinure mu nganda z'ibiryo, HPMC ifite uruhare runini mu rwego rwo kuzamura imikorere n'umutungo w'ibicuruzwa byinshi. Ubushobozi bwo guhuza imiterere yacyo muguhindura urwego rwo gusimbuza nuburemere bwa molekile bigira uruhare mu guhuza n'imihindagurikire.