Gushyira mu bikorwa hydroxyPropyl methylcellse mu nganda za farumasi

HYPROMMOMELLOSE (HPMC) ni ukomoka kuri selile byakoreshwaga cyane mu nganda za farumasi kubera imitungo myiza yabyo na biocompat. Ahantu nyamukuru bya porogaramu birimo imiyoboro ya tablet, gusenyuka, ibikoresho byo gusiga, bikomeza-kurekura imiti, no gutegura ibiyobyabwenge na gels.

1. Bunders

Mubikorwa bya tablet, HPMC nkumudendezi burashobora kuzamura imbaraga zihuza ibiyobyabwenge, bibafasha gukora ibinini bihamye mugihe cya keza. HPMC binders ifite ibyiza bikurikira:
Ongeraho imbaraga zubururu: Umuyoboro wa Viscous wakozwe na HPMC muri tablet ifasha kuzamura imbaraga zubukanishi ya tablet no kugabanya ibyago byo gutandukana no gusenyuka.
Kunoza uburinganire: Bitewe nubukebwe bwayo mumazi, HPMC irashobora gukwirakwizwa neza ku bice kugirango bibe ibiyobyabwenge bihamye muri buri tablet.
Guhagarara: HPMC yerekana ko ituje ryiza mubushyuhe nubushyuhe butandukanye, kandi irashobora kubungabunga imiterere ya tablet mugihe kidashobora kwiyongera kubidukikije.

2. Gutandukanya

Imikorere ya sentintegrants nugukora ibinini bitandukanya vuba nyuma yo guhura namazi kugirango akureho ibiyobyabwenge. HPMC irashobora guteza imbere isura ya tablettegrategration kubera imitungo yo kubyimba:
Kubyimba kwa hydration: Iyo HPMC ihuye namazi, izakura vuba amazi kandi ikabyimba, bigatuma imiterere ya tablet yo guturika, bityo birekura ibiyobyabwenge.
Guhindura igihe cyo gusenyuka: Muguhindura visosity ya HPMC, igihe cyo gusenyuka cyibisate birashobora kugenzurwa neza kugirango byubahirize ibisabwa birekuwe ibiyobyabwenge bitandukanye.

3. Ibikoresho byo gutwika

HPMC igira uruhare runini mu gukinisha tablet. Ubushobozi bwayo buhebuje bwa firime nuburinganire ku biyobyabwenge bikabigira ibikoresho byiza byo gutwikira:
Ingaruka zo kwigunga: Gutinda HPMC birashobora gutandukanya neza ibintu bifatika muri tablet mubidukikije byo hanze kugirango birinde disiki, okiside kandi ifoto.
Kunoza kugaragara: Guti kwa HPMC birashobora gutanga hejuru yinyuma, biteza imbere isura no korohereza kumira ibinini.
Guhindura Kurekura Ibiyobyabwenge: Binyuze mu bikoresho bitandukanye bya HPMC no gukingirwa bikabije, hagenzurwa irekurwa cyangwa kurekurwa birambye birashobora kugerwaho.

4. Abakozi bahorewe

HPMC ikoreshwa cyane mu myiteguro irambye. Binyuze kuri Gel barrière, birashobora gutinza kurekurwa no kugera ku buvuzi burebure:
Inzitizi ya Gel: Mu bitangazamakuru bya akeous, HPMC irashonga kandi ikagira gel ya viscous, ishobora kugenzura umubare w'ibiyobyabwenge.
Kurekurwa neza: viscosiya hamwe na HPMC birashobora kugenzurwa neza kugirango bigerweho bihamye kandi biteganijwe.
Hagabanije imiti: Ifishi irambye-irekura dosiye irashobora kugabanya inshuro zimiti kubarwayi no kunonosora kubahiriza no gukora neza kwivuza.

5. Itegurwa ryamazi na gels

HPMC igira uruhare runini nkuwabyimbye kandi stilizer mumateguro y'amazi na gels:
Ingaruka zijimye: HPMC ikora igisubizo kimwe cya colloidal mumazi, kirashobora kongera viscolity yo gutegura amazi no kunoza umutekano.
Ingaruka zihamye: HPMC irashobora gukomeza vicosi zihamye mubihe bitandukanye p p ph, bifasha kugabanya ibiyobyabwenge no kwirinda imvura no kwirinda.

6. Ibindi bikorwa

HPMC ikoreshwa no gutegura imyiteguro yo hejuru, imyiteguro yizura no kwitegura gusaba byimazeyo:
Imyiteguro ya Ophthalmic: HPMC ikoreshwa nkuburozi mumarira ahinnye kandi atonyanga kugirango akureho ibimenyetso byumye.
Imyiteguro ya Nasal: Nkumubyimba mu mazuru, HPMC irashobora kuramba igihe cyo kumubuza ibiyobyabwenge mubyaro by'ejo.
Imyiteguro yibanze: HPMC irashobora gukora firime yo kurinda mu myiteguro yibanze kugirango ifashe ibiyobyabwenge kuguma kuruhu igihe kirekire.

Nkibikorwa byimikorere, hydroxypropyl methylcellse ikoreshwa cyane mubikorwa byimiti. Imikorere myinshi yo gukora tablet ikora, ikunda, ikureho imyiteguro, itegurwa ryamazi hamwe na gels yonoza cyane ubuziranenge no gutumiza kwitegura ibiyobyabwenge. HPMC yabaye ibintu bitarangwa kandi byingenzi mumibare ya farumasi kubera ibinyabuzima byayo byiza nibikorwa bikora. Mugihe kizaza, hamwe no guteza imbere ikoranabuhanga rya farumasi, ibyifuzo bya HPMC mubushakashatsi bwibiyobyabwenge no guteza imbere no guteza imbere no guteza imbere no gushyiraho bizaba bigari.