Abashiraho selile ni icyiciro cyimiterere ya selile yahinduye imitima nkamazi meza cyane, imitungo yo gukora film, ingufu, guhagarikwa no guhinga umutungo, kandi bikoreshwa cyane munganda za farumasi. Bitewe na biocompat hamwe numutekano, abatanga seliki bagira uruhare runini mu myiteguro ya farumasi.
1. Ibikoresho bya Matrix kubitegura bigenzurwa
Mu nganda z'imiti, igenzurwa-igenzurwa ni ibyiciro byimyidagaduro ya farumasi itera ingaruka zibi mugenzura ibiyobyabwenge. Abashiraho selile bakunze gukoreshwa nkibikoresho bya Matrix kubitegura bigenzurwa bitewe nubuzima bwabo bwihariye bwumubiri nu miti. HydroxyPropyl Methylcellse (HPMC) nimwe murimwe wakoreshwaga cyane na selile. Irashobora gukora gel mumazi kandi irashobora kugenzura neza igipimo cyibiyobyabwenge. Muguhindura vino, urwego rwo gusimbuza no kubirimo muri selile mugutegura, ibiranga ibiyobyabwenge birashobora guhinduka nkuko bikenewe. Ibi bituma abakoresha selile ibikoresho byiza matrix kugirango birekure, bigenzurwa-kurekura no kurekura-kurekura.
2. Binders
Mu gukora ibisate, abakoresha seliki barashobora gukoreshwa nka bunders kugirango bagabanye imyenda imwe nimbaraga zamaniki. Cyane cyane muburyo butose, sodium carboxymethyll selile (cmc-na) na hydroxyProppopyl Byongeye kandi, Gushyira mu bikorwa abayobozi ba selile mu bisate birashobora kandi kunoza ibyokurya by'ibisate, kugira ngo imiti ishobora kurekurwa mu mubiri no kunoza ibinyabuzima.
3. Ibikoresho byo gutwika firime
Abahanga ba selile nabo barakoreshwa cyane mubitagenda neza. Nkibintu bifatika, hydroxypropyl methylcellse ifite imitungo myiza ya firime kandi irashobora kunoza neza umutekano, kurwanya ubushuhe no kugaragara kubinini byabayobyabwenge. Filime elmal Film irashobora kandi gutinza irekurwa ryibiyobyabwenge kugirango igere ku bigereka byahagaritswe cyangwa byinjira. Byongeye kandi, mu guhuza na selikiya hamwe nabandi bibabazwa, amatara hamwe nimirimo itandukanye, nko kurekura vuba, kurekura amatara, amakera yinjira, nibindi, kugirango ubone ibikenewe mubiyobyabwenge bitandukanye.
4. Trackeners nintara
Mu myiteguro y'amazi, Amagana no guhagarike, abatanga seliki bafite uruhare runini nk'abarimbyi n'intangarugero. Irashobora kongera viscolity yumuti no kunoza ihagarikwa ry'ibiyobyabwenge, bityo tuzemeza uburinganire kandi butuje ku biyobyabwenge. Kurugero, mumyiteguro ya Ophthalmic hamwe no guhagarikwa mu kanwa, sodiyumu carboxymethyll selileulose nkuko ubugome burashobora kuzamura imiti no gutuza kw'ibiyobyabwenge mu gihe cyo gukoresha. Byongeye kandi, abakoresha selile batwara neza mubijyanye na biocompaget nubusa, kandi ntibatera uburakari cyangwa ibisubizo bya allergique, bikaba bikoreshwa cyane cyane mubuvuzi bwa Ophthalmic.
5. Ibikoresho byo kwitegura Capsule
Abakoresha Cellus barashobora kandi gukoreshwa nkibikoresho bya capsule yitegura bya capsu, cyane cyane mugutegura capsules zishingiye ku gihingwa. Ibikoresho gakondo bya capsule ni Gelatin, ariko hamwe nibimera hamwe nabantu bazwi cyane hamwe nabantu ba allergique, icyifuzo cyibikoresho bya caple biva mu masoko bigenda byiyongereye buhoro buhoro. Abayobozi ba selile nka HydroxyPropyl Methylcellse babaye igice cyingenzi cya capsules zishingiye ku gihingwa. Ubu bwoko bwa capsule ntabwo bufite gusa kwitonda gusa, ahubwo itanga imbaraga zubukanishi n'umutekano bya Gelatin Capsules, biba bikenewe ibikomoka ku bimera ndetse n'abaturage bumva imikoreshereze y'ibiyobyabwenge.
6. Gusaba mu magambo no kwitegura
Abahanga ba selile na bo bakoreshwaga cyane mu myiteguro yo mu kanwa. Bitewe nubupfa bwiza kandi bivuguruzanya, abakoresha selile barashobora gukora film yo kurinda kumvugo cyangwa ubuso bwuruhu, kwikura neza mugihe cyibiyobyabwenge ahabigenewe. Kurugero, mu magambo asenyuka ku munwa, amenyo n'amavuta yoroheje, abashiraho selire barashobora kugira uruhare runini nk'abatwara ibiyobyabwenge kandi bakazamura ingaruka z'ibiyobyabwenge.
7. MicroenCaplatilation na Sisitemu yo gutanga ibiyobyabwenge
Abakoresha TOLULULOULOULOULOSE nabo barashobora gukoreshwa mukubaka sisitemu microeencaplatilation na sisitemu yo gutanga ibiyobyabwenge. Mugihe utegura microcapsules cyangwa nanoparticles, bahanganye na selile bakunze gukoreshwa nkibikoresho byo gusiganwa cyangwa abatwara ibicuruzwa bizagera kure, bigenzurwa bigerwaho byahagaritswe ndetse no gutanga bigamije no gutanga ibiyobyabwenge. Kurugero, hydroxypropyl methylcellse na Carboxymethyll Thansilose bagira uruhare runini mugutegura ibiyobyabwenge bimaze igihe kirekire. Abatangagosha ba selile ntibashobora kurinda ibiyobyabwenge gusa ku ngaruka zishingiye ku bidukikije, ariko nanone kurangira igihe cyiza cyibiyobyabwenge mumubiri ugenga uburyo bwo kurekura.
Abashiraho selile bakoreshwa cyane mu nganda z'imiti, zikubiyemo imirima itandukanye igenzurwa, ibibaya, n'ibindi. Hamwe no guteza imbere ikoranabuhanga ryikoranabuhanga rya farumasi, ubushobozi bwabaturage buzagurwa cyane, cyane cyane mumirima mishya yo gutanga ibiyobyabwenge, imiti isebanya hamwe na biobicicine na biomedicine, bahanganye, bahanganye na selile bazakomeza kugira uruhare runini.
Igihe cyagenwe: Gashyantare-17-2025