Joseph Brama yahimbye inzira yo kwiyongera kugira ngo umusaruro ushyireho imiyoboro mu mpera z'ikinyejana cya 18. Ntabwo cyari kigeze mu kinyejana cya 19 ko ikoranabuhanga rishyushye rishyushye ryatangiye gukoreshwa mu nganda za plastiki. Byakoreshejwe bwa mbere mugukora ibicuruzwa bya polymer kugirango atsindira amashanyarazi. Uyu munsi, gushonga gushonga byakoreshejwe cyane ntabwo bikoreshwa cyane mugukora ibicuruzwa bya polymer, ariko no mubyakozwe no kuvanga polymers ubwabo. Kugeza ubu, ibirenze kimwe cya kabiri cyibicuruzwa bya plastike, harimo imifuka ya pulasitike, impapuro za plastike hamwe nimiyoboro ya plastike, zikorwa ukoresheje iyi nzira.
Nyuma, ikoranabuhanga ryagaragaye buhoro buhoro mumwanya wa farumasi hanyuma uhinduka ikoranabuhanga ridasanzwe. Noneho abantu bakoresha ikoranabuhanga rishyushye bashyushye kugirango bategure granules, haragukuye ibinini birekura ibinini, sisitemu yo gutanga ibicuruzwa hamwe na transucosal na transucosal sisitemu yo gutanga ibiyobyabwenge nibindi. Kuki abantu bakunda iyi ikoranabuhanga muri iki gihe? Impamvu iterwa ahanini nuburyo ugereranije nuburyo bwo gukora umusaruro gakondo, ishoka ishyushye yashonga ifite ibyiza bikurikira:
Kunoza igipimo cyo kuvuka cyibiyobyabwenge nabi
Hari ibyiza byo gutegura haje haragurika
Gutegura abakozi ba Gastrointestinal basohotse bafite umwanya mwiza
Kunoza uburyo bwo kwikuramo
Inzira yo gusiga irasohoka mu ntambwe imwe
Fungura inzira nshya yo gutegura micropellets
Muri bo, Ether, Ether igira uruhare runini muri iki gikorwa, reka turebe ikoreshwa rya selile yacu muri yo!
Gukoresha Ethyl selile
Ethyl selile ni ubwoko bwa hydrophobic ether selile. Mu murima wa farumasi, ubu yakoreshejwe muri microenCaplation y'ibintu bikora, umukemuragurika hamwe na granulation ya extrike, imiyoboro ya tablet, no guswera no gutwarwa no kugenzurwa na table yagenzuwe n'amasaro. Ethyl selile irashobora kongera uburemere butandukanye bwa moleka. Ubushyuhe bwinzibacyuho ni dogere 129-133333, hamwe na kirisiti ya kristu ni dogere dodes 180. Ethyl selile ni amahitamo meza yo kwiyongera kuko byerekana imitungo ya thermoplastique hejuru yubushyuhe bwinzibacyuho no munsi yubushyuhe bwabwo.
Kugirango ugabanye ubushyuhe bwinzibacyuho cya polymers, uburyo busanzwe ni ukukongeramo plastistizers, bityo birashobora gutunganywa ku bushyuhe buke. Ibiyobyabwenge bimwe birashobora gukora nka plastizars ubwabo, ntabwo rero bikenewe kongera kongeramo abashitsi mugihe cyo gutanga ibiyobyabwenge. Kurugero, wasangaga firime zagaragaye zirimo ibuprofen na ethyl selile bari bafite ubushyuhe bwinzibacyuho nto kuruta firime zirimo extll selile. Izi firime zirashobora gutangwa muri laboratoire hamwe na mpanga zo kuzunguruka-strew strew. Abashakashatsi nabo bawushyira mu ifu hanyuma bagakora isesengura ryumuriro. Byaragaragaye ko kongera umubare wa IBUPROFN irashobora kugabanya ubushyuhe bwinzibacyuho.
Ubundi bushakashatsi bwari bwo kongeramo abababayeho hydrophilic, Hyppimellose, Hyppimellose, na Xanthan gum to Rothromatlliulose na Ibukafen MicroMaticices. Yanzuye ko MicroMatrix yakozwe na tekinike ishyushye ishyushye yari ifite uburyo buhoraho bwo gukoresha ibiyobyabwenge kuruta ibicuruzwa bihari. Abashakashatsi bakoze micromatrix bakoresheje laboratoire yo kuzunguruka hamwe na Twin-strew struder hamwe na 3-cylindrike. Impapuro zaciwe nintoki zari mm 2 z'uburebure.
SYPROMMELLOSE Koresha
HydroxyPropyl methylcellse ni hydrophilic selile yabujije ngo ibintu bisobanutse cyangwa bike bine byamazi akonje. Igisubizo cyamazi gifite ibikorwa byo hejuru, gukorera mu mucyo bikabije hamwe n'imikorere ihamye. Kukesha agaciro biratandukanye na viscosiya. Kumanura viscosiya, niko kwitonda. Imitungo ya hydroxypropyl methylcellse hamwe nibisobanuro bitandukanye biratandukanye, kandi iseswa ryayo mumazi ntabwo rigira ingaruka ku gaciro ya PH.
Mu nganda za farumasi, akenshi zikoreshwa mu kugenzurwa Matrix, gutunganya ibipimo bya tablet, ibishushanyo mbonera, n'ibindi bisobanura ibisimbura 160-210 birenga kuri dogeresi 250. Kubera ubushyuhe bwinzibacyuho ndende kandi ubushyuhe buke bwo gutesha agaciro, ntabwo bukoreshwa cyane mubuhanga bushyushye. Kugirango wange urugero rwayo, uburyo bumwe ni uguhuza gusa na plastisar gusa mubikorwa byo gushyingirwa nkuko intiti zombi zavuze, kandi ukoreshe matric of matrix ya matrix yibura byibuze 30%.
Ethylcellse na HydroxyPropylmethylcellcelllcellCellsell irashobora guhuzwa muburyo budasanzwe mugutanga ibiyobyabwenge. Bumwe muribi bikorwa ni ugukoresha Ethylcellse nkumuyoboro wo hanze, hanyuma utegure Hyppimellose icyiciro cyo hejuru. Shingiro.
Gukavumbura Ethlcellsellse hakozwe hakoreshejwe imashini ishyushye muri mashini izunguruka muri laboratoire yinjiza impeta ya laboratoire ihindura intoki kugeza ishonga, ikurikirwa na homogenisation. Ibikoresho byingenzi noneho bigaburirwa intoki mumuyoboro. Intego yubu bushakashatsi kwari ugukuraho ingaruka zo gukubitwa ibyo rimwe na rimwe bibaho muri hydroxypropyl methylcellse tableti. Abashakashatsi basanze nta tandukaniro mu buryo bwo kurekura ibicuruzwa kuri hydroxyproppopyl methylcellrose ya viscosity ya virusizol methylcellse hamwe na methylcellse byatumye habaho igipimo cyihuse cyo kurekura.
Outlook
Nubwo bishyushye bishyushye ni tekinoroji mishya mu nganda za farumasi, yakwegereye ibitekerezo byinshi kandi ikoreshwa mugutezimbere umusaruro wa dosiye zitandukanye na sisitemu. Ikoranabuhanga rihamye rishyushye ryabaye ikoranabuhanga rikomeye ryo gutegura itana rikomeye mu mahanga. Kuberako amahame ya tekinike asa nuburyo bwinshi bwo kwitegura, kandi bwakoreshejwe muyindi nganda imyaka myinshi kandi akusanya uburambe bwinshi, ifite uburambe bwiterambere. Hamwe no kwimbitse ubushakashatsi, bizera ko gusaba byayo bizagurwa. Mugihe kimwe, ikoranabuhanga rishyushye rishyushye rifite ibibazo bike nibiyobyabwenge nurwego rwo hejuru rwikora. Nyuma yinzibacyuho mu nganda za farumasi, bizera ko impinduka zagabanwa zizaba byihuse.
Igihe cyagenwe: Feb-14-2025