Gushyira mu bikorwa hydroxyproppopyl selile ya selile mugutegura bikomeye

HydroxyPropyl Cellulose, abarimu bakuru, bagabanijwemo hydroxypropyl. L-hpro) na hydroxyproppopyl selile L-HPC yabyimbye mu gisubizo cya colloidal mu mazi, ifite imitungo ya Adhesion, gushiraho firime, kuzenguruka, nibindi bikoreshwa cyane nkumukozi usenyuka na bunder; Mugihe H-HPC irashonje mumazi hamwe nibicuruzwa bitandukanye mu bushyuhe bwicyumba, kandi bifite ubwoba bwiza. , ihuriro n'imitungo yo gukora film, filime yashyizweho ni ibintu bikomeye, byiza, kandi bikoreshwa cyane, kandi bigakoreshwa cyane nkibikoresho bigize film hamwe nibikoresho bifatika. Gushyira mu bikorwa hydroxyProppepyl selile mu myiteguro ikomeye iratangizwa.

1. Nkibintu bitandukanijwe kugirango imyiteguro ikomeye nkibinini

Ubuso buke-busimburwahydroxypropyl selileIbice bya Crystalline ntabwo biringaniye, bifite imiterere igaragara nkimiterere. Iyi miterere yubuso ntizituma ifite ahantu hanini gusa, ariko kandi iyo ihagaritswe mubiyobyabwenge hamwe nibiyobyabwenge hamwe nabandi ba tablet, kugirango tablet yibanze yiyongere kandi yinjizemo amazi. Gukoresha L-HPC nk'igiterwa gishobora gutuma tablet isenyuka vuba muri ifu imwe, kandi itezimbere cyane ibisebe, gusenya hamwe na bioatseilability of tablet. Kurugero, ikoreshwa rya L-HPC rirashobora kwihutisha gusenya ibinini bya paracetamol, ibisate bya aspirin, na chlorphendemine tabletimine, no kunoza igipimo cyivumburwa. Gusenya no gusesa ibiyobyabwenge byoroheje nkibinini bya onloxacin hamwe na L-HPC nkibicapo byari byiza cyane kuba hamwe na PVP yambukiranya PVPS, CMC-Na na CMS-NA NUBUNTU. Ukoresheje L-HPC nk'imbere y'imbere mu modoka yo mu murongo wa capsules igira akamaro mu buryo bwo gusebanya, yongera ahantu hatunganijwe hagati y'ibiyobyabwenge n'ibipimo byo gusesengura ibiyobyabwenge, kandi biteza imbere ibinyabuzima. Guhita uhita ugereranywa no kwihuta - gusenya imyiteguro ikomeye hamwe nimyiteguro yihuse-isenyuka, kugabanya ibiyobyabwenge, bikaba byoroshye gufata kandi byoroshye gufata no kubahiriza neza. N'izindi nyungu, ifite umwanya w'ingenzi mu rwego rwa farumasi. L-HPC yabaye umwe mubantu bakomeye kugirango bahitemo imyiteguro ikomeye kubera hydrofilirity yayo ikomeye, hygroscopity, uburyo bugufi, kwihuta cyane mugihe cyo kwihuta k'amazi, kandi yihuta cyane. Numucyo mwiza wo gusenya ibinini byamavurungano. Paracetamol Kumurongo usenya ibinini byateguwe na L-HPC nkintangarugero, kandi ibinini byateshutse vuba muri 20. L-HPC ikoreshwa nkibisobanuro kubinini, hamwe na dosage rusange ni 2% kugeza 10%, ahanini 5%.

2. Nkumuyoboro wo kwitegura nka tableti na granules

Imiterere itoroshye ya L-HPC ituma ifite ingaruka nini ya mozaike hamwe nibiyobyabwenge nibice, byongera urwego rwubwoba, kandi ufite imikorere myiza yo kwigana imikorere. Nyuma yo gukandagira mubisate, byerekana ubukana no gukomera, bityo bituma ireme ryibigaragara. Cyane cyane kubibi bitari byoroshye gushiraho, kurekura cyangwa byoroshye kubigaragaza, kongeramo l-hpc birashobora kunoza ingaruka. Ikibaho cya cyuma cya cyuma gifite uburyo bubi, byoroshye gutandukana no gukomera, kandi biroroshye gushiraho nyuma yo kongera l-HPC, hagaragara urugero rukomeye, isura nziza, hamwe nigipimo cyimiterere yujuje ubuziranenge busabwa. Nyuma yo kongera l-HPC mubinini bidahimbye, isura yayo, ikorwa, itandukanya uburinganire nibindi biterane cyane kandi byanonosowe. Nyuma yuko ibinyamisogwe mu nyandiko y'umwimerere yasimbuwe na L-HPC, ubukomere bwa Azithromycin Tablet yatatanye, akabazwa yarayongereye, kandi ibibazo byo kubiri kwabuze ibinini byumwimerere byakemuwe. L-HPC ikoreshwa nka bunder kubinini, kandi dosage rusange ni 5% kugeza kuri 20%; Mugihe H-HPC ikoreshwa nkuguhuza ibinini, granules, nibindi, hamwe na dosage rusange ni 1% kugeza 5% yo kwitegura.

3. Gusaba muri firime no gukomera no kugenzura imyiteguro yo kurekura

At present, water-soluble materials commonly used in film coating include hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) and so on. HydroxyPropyl Cellulose ikoreshwa nkumukozi ushinzwe film muri firime yerekana ibikoresho premidient kubera filime yayo ikomeye, ya elastike na glastique na glosti na glastique na glastique na glastique na glastique na glastique na glastique na glostique na glastique na glastique na glastique na glastique na glastique na glastique na glastique na glosti na glastique na glastique na glosti na flastique na glostique na glastique na glastique na glastique na glastique na glastique na glastique na glastique na glastique na glastique na glosti na glastique na glastique na glosti na glastique na glastique. Niba hydroxyPropyl selile ivanze nubundi bushyuhe burwanya ubushyuhe, imikorere yo gukinisha irashobora gukomeza kurushaho.

Gukoresha ababanjirije hamwe nubuhanga bwo gukora ibiyobyabwenge mubinini bya Matrix, ibinini bireremba, ibinini byinshi, ibinini bya osmotike, bigenzurwa nibiyobyabwenge kandi bigabanuka ibiyobyabwenge no guhungabanya ibiyobyabwenge mumaraso. Kwibandaho, kugabanya ibintu bibi, kugabanya imiti, hanyuma uharanire kugwiza ingaruka zo gukiza hamwe nigipimo gito, hanyuma ukureho ingaruka mbi. HydroxyPropyl selile nimwe mubarikirwa nyamukuru muri ubwo bwitegurwa. Iseswa no gusohora ibinini bya sodium bigenzurwa na dicloxy bigengwa ukoresheje hydroxyProppopyl selile na Ethyl selile hamwe nibikoresho bihuriweho nibikoresho bya skeleton na skeleton. Nyuma yubuyobozi bwo mu kanwa no guhura numutobekazi, ubuso bwa sodium ya diclofenAc yakomeje-kurekura ibisate bizabohoza muri gel. Binyuze mu iseswa rya gel no kuri diffusion ya molekile zo mu biyobyabwenge mu gitsina gane, intego yo kurekura gahoro galecule iragerwaho. HydroxyPropyl Selilese ikoreshwa nka Matrix-Kurekura Matrix ya Tablet, mugihe ibikubiye muri Tablet Exetule, kandi ibiyobyabwenge biri muri tablet bikomeza kurekura ibiyobyabwenge. Pellet yatwitswe yateguwe ukoresheje L-HPC hamwe nigice runaka cya HPMC nkigisubizo cyo guhora cyo kwifuza, kandi nkigice kigenzurwa cyo gusiga hamwe na extlel selile. Iyo udukoni twabyimbye kandi dosiye irakosowe, nugenzura ubunini bwa cheer igenzurwa, pellet yatwitswe irashobora kurekurwa mubihe bitandukanye. Ubwoko butandukanye bwa pellets hamwe ninyungu zitandukanye zo gusohora kugenzurwa zivanze zivanze kugirango Shuxiong ikomeze-kurekura capsules. Mu rwego rwo gusenya, pellet zitandukanye zanditse zirashobora kurekura ibiyobyabwenge bikurikiranye, kugirango ibice bitandukanye byumubiri na shimi icyarimwe birekurwe bitagerwaho mugihe kimwe